Y‐box protein 1 promotes hypoxia/reoxygenation‐ or ischemia/reperfusion‐induced cardiomyocyte apoptosis via SHP‐1‐dependent STAT3 inactivation
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.29474
Abstract: Cardiomyocyte apoptosis induced by hypoxia and ischemia plays important roles in heart dysfunction after acute myocardial infarction (AMI). However, the mechanism of apoptosis induction remains unclear. A previous study reported that Y‐box protein 1 (YB1)… read more here.
Keywords: apoptosis; stat3; induced cardiomyocyte; ischemia ... See more keywords
Sevoflurane prevents hypoxia/reoxygenation-induced cardiomyocyte apoptosis by inhibiting PI3KC3-mediated autophagy
Sign Up to like & getrecommendations! Published in 2018 at "Human Cell"
DOI: 10.1007/s13577-018-00230-4
Abstract: Cardiomyocyte apoptosis plays an important role in ischemia/reperfusion (I/R)-induced myocardial injury. Autophagy is suggested to be widely implicated in regulating cell survival and death. The cardioprotection of sevoflurane postconditioning has been long recognized, but the… read more here.
Keywords: hypoxia reoxygenation; induced cardiomyocyte; sevoflurane; cardiomyocyte apoptosis ... See more keywords
Mechanism of miR-126 in hypoxia-reoxygenation-induced cardiomyocyte pyroptosis by regulating HMGB1 and NLRP3 inflammasome
Sign Up to like & getrecommendations! Published in 2022 at "Immunopharmacology and Immunotoxicology"
DOI: 10.1080/08923973.2022.2054819
Abstract: Abstract Objective Pyroptosis refers to the programmed cell death. This study evaluated the mechanism of miR-126 in hypoxia-reoxygenation (HR)-induced cardiomyocyte pyroptosis. Methods The HR rat cardiomyocyte models were established. The cell viability, cytotoxicity, and levels… read more here.
Keywords: hmgb1; pyroptosis; cardiomyocyte pyroptosis; mir 126 ... See more keywords
MicroRNA miR-215-5p Regulates Doxorubicin-induced Cardiomyocyte Injury by Targeting ZEB2
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Cardiovascular Pharmacology"
DOI: 10.1097/fjc.0000000000001110
Abstract: Abstract: Doxorubicin (DOX) is a chemotherapeutic drug for treating various cancers. However, the DOX-induced cardiotoxicity greatly limits its clinical application. MicroRNAs are emerged as critical mediators of cardiomyocyte injury. This work explored the function of… read more here.
Keywords: mir 215; dox induced; induced cardiomyocyte; injury ... See more keywords
The Regulatory Mechanism and Effect of RIPK3 on PE-induced Cardiomyocyte Hypertrophy.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of cardiovascular pharmacology"
DOI: 10.1097/fjc.0000000000001293
Abstract: ABSTRACT As a critical regulatory molecule, receptor-interacting protein kinase 3 (RIPK3) can mediate the signaling pathway of programmed necrosis. Calcium/calmodulin-dependent protein kinase II (CaMKII) has been proved as a new substrate for RIPK3-induced necroptosis. In… read more here.
Keywords: cardiomyocyte hypertrophy; hypertrophy; ripk3; ripk3 induced ... See more keywords
miR-15b-5p REGULATES THE NLRP3 INFLAMMASOME SIGNAL THROUGH TARGETING SIRT3 TO REGULATE HYPOXIA/REOXYGENATION-INDUCED CARDIOMYOCYTE PYROPTOSIS PROCESS
Sign Up to like & getrecommendations! Published in 2022 at "Shock"
DOI: 10.1097/shk.0000000000001961
Abstract: ABSTRACT Hypoxia/reoxygenation (H/R) induces pyroptosis in the setting of acute myocardial infarction (AMI). Previous studies have shown that the expression of the miR-15 family is stimulated in myocardial ischemia–reperfusion injury or H/R-induced cardiomyocyte injury, and… read more here.
Keywords: mir 15b; pyroptosis; cardiomyocyte pyroptosis; injury ... See more keywords
Roles of autophagy in angiotensin II‐induced cardiomyocyte apoptosis
Sign Up to like & getrecommendations! Published in 2022 at "Clinical and Experimental Pharmacology and Physiology"
DOI: 10.1111/1440-1681.13719
Abstract: Autophagy is a self‐degradation process of cytoplasmic components and occurs in the failing heart. Angiotensin II plays a critical role in the progression of heart failure and induces autophagy. We investigated the mechanism underlying angiotensin… read more here.
Keywords: angiotensin; angiotensin induced; apoptosis; autophagy angiotensin ... See more keywords
miR-197 Participates in Lipopolysaccharide-Induced Cardiomyocyte Injury by Modulating SIRT1
Sign Up to like & getrecommendations! Published in 2022 at "Cardiology Research and Practice"
DOI: 10.1155/2022/7687154
Abstract: Sepsis is a systemic inflammation and is capable of inducing myocarditis, which is a major leading cause of death in patients. Studies have found that miR-197 is correlated with the prognosis of patients with inflammatory… read more here.
Keywords: h9c2 cells; cardiomyocyte injury; mir 197; induced cardiomyocyte ... See more keywords
Qishen Yiqi dropping pills improve isoproterenol-induced cardiomyocyte hypertrophy by regulating X-inactive specific transcript (XIST) expression in rats
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Thoracic Disease"
DOI: 10.21037/jtd-22-606
Abstract: Background This study aimed to explore the potential mechanism of Qishen Yiqi dropping pills (QYDPs) in the treatment of chronic heart failure (CHF) by regulating the expression of lncRNAs during CHF. Methods Differences in the… read more here.
Keywords: xist expression; cardiomyocyte hypertrophy; qishen yiqi; expression ... See more keywords
Knockdown of long non-coding RNA LUCAT1 reverses high glucose-induced cardiomyocyte injury via targeting CYP11B2.
Sign Up to like & getrecommendations! Published in 2019 at "European review for medical and pharmacological sciences"
DOI: 10.26355/eurrev_201910_19171
Abstract: OBJECTIVE Diabetic cardiomyopathy (DCM) is one of the major complications in patients with diabetes mellitus. Recently, long noncoding RNAs (lncRNAs) have been well concerned for their roles in the progression of multiple diseases, including DCM.… read more here.
Keywords: high glucose; cardiomyocyte injury; induced cardiomyocyte; lucat1 ... See more keywords
Curcumin attenuates hypoxia/reoxygenation-induced cardiomyocyte injury by downregulating Notch signaling
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Medicine Reports"
DOI: 10.3892/mmr.2019.10371
Abstract: Recovery of the blood supply is the most effective treatment against ischemic heart disease; however, it is also a major cause of myocardial ischemia/reperfusion injury in clinical therapy. Curcumin has been reported to possess beneficial… read more here.
Keywords: hypoxia reoxygenation; reoxygenation induced; cardiomyocyte injury; induced cardiomyocyte ... See more keywords