Attenuation of miR-34a protects cardiomyocytes against hypoxic stress through maintenance of glycolysis
Sign Up to like & getrecommendations! Published in 2017 at "Bioscience Reports"
DOI: 10.1042/bsr20170925
Abstract: MiRNAs are a class of endogenous, short, single-stranded, non-coding RNAs, which are tightly linked to cardiac disorders such as myocardial ischemia/reperfusion (I/R) injury. MiR-34a is known to be involved in the hypoxia-induced cardiomyocytes apoptosis. However,… read more here.
Keywords: glycolysis; mir 34a; induced cardiomyocytes; time hypoxia ... See more keywords
Efficient Direct Lineage Reprogramming of Fibroblasts into Induced Cardiomyocytes Using Nanotopographical Cues.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of biomedical nanotechnology"
DOI: 10.1166/jbn.2017.2347
Abstract: Induced cardiomyocytes (iCMs) generated via direct lineage reprogramming offer a novel therapeutic target for the study and treatment of cardiac diseases. However, the efficiency of iCM generation is significantly low for therapeutic applications. Here, we… read more here.
Keywords: direct lineage; induced cardiomyocytes; lineage reprogramming; reprogramming fibroblasts ... See more keywords
Inhibition of miR-153 ameliorates ischemia/reperfusion-induced cardiomyocytes apoptosis by regulating Nrf2/HO-1 signaling in rats
Sign Up to like & getrecommendations! Published in 2020 at "BioMedical Engineering OnLine"
DOI: 10.1186/s12938-020-0759-6
Abstract: Background Previous in vitro studies demonstrated that suppression of microRNAs might protect cardiomyocytes and neurons against oxygen–glucose deprivation and reoxygenation (OGD/R)-induced cell apoptosis. However, whether the protective effect of miR-153-inhibition on cardiomyocytes can be observed… read more here.
Keywords: cardiomyocytes apoptosis; inhibition mir; mir 153; induced cardiomyocytes ... See more keywords
Rhynchophylline ameliorates myocardial ischemia/reperfusion injury through the modulation of mitochondrial mechanisms to mediate myocardial apoptosis
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Medicine Reports"
DOI: 10.3892/mmr.2019.9908
Abstract: Rhynchophylline (RP), the primary active ingredient of Uncaria rhynchophylla, has an anti-hypertensive effect and protects against ischemia-induced neuronal damage. The present study aimed to examine the roles and mechanisms of RP in myocardial ischemia-reperfusion (MI/R)… read more here.
Keywords: apoptosis; myocardial ischemia; induced cardiomyocytes; ischemia ... See more keywords