Multiscale Anisotropic Scaffold Integrating 3D Printing and Electrospinning Techniques as a Heart-on-a-chip Platform for Evaluating Drug-induced Cardiotoxicity.
Sign Up to like & getrecommendations! Published in 2023 at "Advanced healthcare materials"
DOI: 10.1002/adhm.202300719
Abstract: Cardiac safety assessments are significant in drug discovery, as drug-induced cardiotoxicity is the primary cause of drug attrition. Despite heart-on-a-chip technology having become an increasingly popular tool for evaluating drug-induced cardiotoxicity, its development remains a… read more here.
Keywords: drug induced; induced cardiotoxicity; cardiotoxicity; drug ... See more keywords
Ixazomib cardiotoxicity: A possible class effect of proteasome inhibitors
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DOI: 10.1002/ajh.24608
Abstract: The introduction of bortezomib has revolutionized the treatment of multiple myeloma (MM) and significantly improved outcomes in MM patients. Similar to many other chemotherapeutic agents, there are numerous reports of bortezomib-induced cardiotoxicity. Furthermore, the FDA… read more here.
Keywords: ixazomib; induced cardiotoxicity; proteasome inhibitors; treatment ... See more keywords
Labdane conjugates protect cardiomyocytes from doxorubicin‐induced cardiotoxicity
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DOI: 10.1002/ddr.22014
Abstract: The cardiovascular side effects associated with doxorubicin (DOX), a wide spectrum anticancer drug, have limited its clinical application. Therefore, to explore novel strategies with cardioprotective effects, a series of new labdane conjugates were prepared (6a–6c… read more here.
Keywords: labdane; induced cardiotoxicity; activity; labdane conjugates ... See more keywords
Integrating analysis of circular RNA and mRNA expression profiles in doxorubicin induced cardiotoxicity mice
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DOI: 10.1002/jat.4257
Abstract: Doxorubicin (DOX)‐induced cardiotoxicity impedes its clinical application, but the mechanisms have not been thoroughly elucidated. Based on circRNA and mRNA expression profiles, we illustrated RNA expression signature changes during DOX‐induced cardiotoxicity; mechanism exploration and biomarkers… read more here.
Keywords: expression profiles; dox induced; induced cardiotoxicity; mrna expression ... See more keywords
Protective effects of salvianolic acid A on clozapine‐induced cardiotoxicity in zebrafish
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DOI: 10.1002/jat.4368
Abstract: The clinical use of clozapine (CLZ), an atypical antipsychotic drug, was affected by side effects, such as cardiotoxicity. We selected normally developing zebrafish embryos to explore the antagonism of salvianolic acid A (SAA) against clozapine‐induced… read more here.
Keywords: induced cardiotoxicity; cardiotoxicity; salvianolic acid; clozapine induced ... See more keywords
Unraveling the biomechanistic role of Rac1/TWEAK/Fn14/NF‐κB intricate network in experimentally doxorubicin‐induced cardiotoxicity in rats: The role of curcumin
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Biochemical and Molecular Toxicology"
DOI: 10.1002/jbt.22829
Abstract: Doxorubicin (DOX) is an important chemotherapeutic drug. Cardiotoxicity diminishes its clinical efficacy. We aimed to focus on the mechanism of DOX‐induced cardiotoxicity, in addition, to evaluate curcumin's protective effect against it. Twenty‐eight rats were divided… read more here.
Keywords: induced cardiotoxicity; group; cardiotoxicity; role ... See more keywords
Trehalose alleviates doxorubicin‐induced cardiotoxicity in female Swiss albino mice by suppression of oxidative stress and autophagy
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Biochemical and Molecular Toxicology"
DOI: 10.1002/jbt.22859
Abstract: Clinically, the use of doxorubicin (DOX) is limited due to DOX‐induced cardiotoxicity (DIC). The current study aimed to evaluate the cardioprotective effect of trehalose (TRE) against DIC in a female Swiss albino mouse model. Mice… read more here.
Keywords: induced cardiotoxicity; group; dox; mice ... See more keywords
PEX1 is a mediator of α1‐adrenergic signaling attenuating doxorubicin‐induced cardiotoxicity
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DOI: 10.1002/jbt.23196
Abstract: Doxorubicin (DOX) is a potent chemotherapeutic agent used for cancer treatment, however, DOX‐induced cardiotoxicity is a serious clinical problem because it causes acute and chronic heart dysfunction. Many studies have indicated that the α1‐adrenergic receptor… read more here.
Keywords: induced cardiotoxicity; pex1; adrenergic signaling; dox induced ... See more keywords
Calycosin ameliorates doxorubicin‐induced cardiotoxicity by suppressing oxidative stress and inflammation via the sirtuin 1–NOD‐like receptor protein 3 pathway
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DOI: 10.1002/ptr.6557
Abstract: The limitation of doxorubicin (DOX), which is widely used for the treatment of solid tumors and hematologic malignancies, is a vital problem in clinical application. The most serious of limit factors is cardiotoxicity. Calycosin (CA),… read more here.
Keywords: induced cardiotoxicity; nod like; like receptor; cardiotoxicity ... See more keywords
Platelet‐rich plasma exhibits anti‐inflammatory effect and attenuates cardiomyocyte damage by reducing NF‐κB and enhancing VEGF expression in isoproterenol induced cardiotoxicity model
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DOI: 10.1002/tox.23456
Abstract: The present study investigated the cardioprotective effects of activated platelet‐rich plasma (PRP) on high dose isoproterenol (ISO) induced cardiotoxicity. ISO was injected at a dose of 85 mg/kg/day, s.c. for 2 days. Cardiac function parameters… read more here.
Keywords: rich plasma; platelet rich; induced cardiotoxicity; platelet ... See more keywords
Aloin alleviates doxorubicin-induced cardiotoxicity in rats by abrogating oxidative stress and pro-inflammatory cytokines
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DOI: 10.1007/s00280-020-04125-w
Abstract: Aloin, an anthraquinone present in the aloe species, possesses antiangiogenic, chemopreventive and antioxidant properties. It exerts cytotoxicity against breast cancer and ovarian cancer cell lines. These properties of aloin project it as a chemopreventive adjuvant… read more here.
Keywords: effects aloin; dox induced; induced cardiotoxicity; cardiotoxicity rats ... See more keywords