LncRNA UCA1 Antagonizes Arsenic‐Induced Cell Cycle Arrest through Destabilizing EZH2 and Facilitating NFATc2 Expression
Sign Up to like & getrecommendations! Published in 2020 at "Advanced Science"
DOI: 10.1002/advs.201903630
Abstract: Abstract Arsenic (As) is a widespread metalloid contaminant, and its internal exposure is demonstrated to cause serious detrimental health problems. Albeit considerable studies are performed to interrogate the molecular mechanisms responsible for As‐induced toxicities, the… read more here.
Keywords: cycle arrest; induced cell; cell cycle; ezh2 ... See more keywords
Curcumin attenuates Cr (VI)‐induced cell growth and migration by targeting autophagy‐dependent reprogrammed metabolism
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Biochemical and Molecular Toxicology"
DOI: 10.1002/jbt.23193
Abstract: Hexavalent chromium [Cr (VI)] is a well‐established carcinogen. Cr (VI)‐treated cells are phenotypically characterized by aberrant levels of growth and migration. Curcumin, a polyphenolic compound from the plant turmeric, has been found to possess antiproliferation,… read more here.
Keywords: migration targeting; induced cell; curcumin; migration ... See more keywords
Inhibition of NAMPT markedly enhances plasma-activated medium-induced cell death in human breast cancer MDA-MB-231 cells.
Sign Up to like & getrecommendations! Published in 2019 at "Archives of biochemistry and biophysics"
DOI: 10.1016/j.abb.2019.108155
Abstract: Plasma-activated medium (PAM), which is prepared by non-thermal atmospheric pressure plasma (NTP) irradiation of cell-free medium, has been shown to exhibit tumor-specific cytotoxicity. Since PAM contains reactive oxygen species (ROS) and reactive nitrogen species (RNS),… read more here.
Keywords: pam; cell death; cancer; cell ... See more keywords
Long non-coding RNA PWRN2 regulates cytotoxicity in an in vitro model of age-related macular degeneration.
Sign Up to like & getrecommendations! Published in 2020 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2020.10.104
Abstract: BACKGROUND Age-related macular degeneration (AMD) may lead to irreversibly vision loss among aging populations. In this work, in an in vitro AMD cell model, we examined the expression and function of long non-coding RNA, Prader-Willi Region… read more here.
Keywords: cell; coding rna; cell death; pwrn2 ... See more keywords
Essential role of the endocytic site-associated protein Ecm25 in stress-induced cell elongation
Sign Up to like & getrecommendations! Published in 2021 at "Cell reports"
DOI: 10.1016/j.celrep.2021.109122
Abstract: SUMMARY How cells adopt a different morphology to cope with stress is not well understood. Here, we show that budding yeast Ecm25 associates with polarized endocytic sites and interacts with the polarity regulator Cdc42 and… read more here.
Keywords: stress; cell elongation; induced cell; essential role ... See more keywords
Interleukin 15 activates Akt to protect astrocytes from oxygen glucose deprivation‐induced cell death
Sign Up to like & getrecommendations! Published in 2017 at "Cytokine"
DOI: 10.1016/j.cyto.2017.01.010
Abstract: HIGHLIGHTSAstrocytes increase expression of the IL‐15/IL‐15R&agr; complex under conditions of oxygen glucose deprivation (OGD).Akt, but not PKC&agr;/&bgr;I, is essential for astrocyte survival in OGD‐induced cell death.IL‐15 activates Akt to protect astrocytes from OGD‐induced cell death.… read more here.
Keywords: death; glucose deprivation; activates akt; oxygen glucose ... See more keywords
BDE-47 induced PC-12 cell differentiation via TrkA downstream pathways and caused the loss of hippocampal neurons in BALB/c mice.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of hazardous materials"
DOI: 10.1016/j.jhazmat.2021.126850
Abstract: As the most abundant congener of polybrominated diphenyl ethers (PBDEs) detected in environment and human biotic samples, 2, 2', 4, 4'-tetrabromodiphenyl ether (BDE-47) has been found to accumulate in brain and induce neurotoxicity, however, the… read more here.
Keywords: bde; trka; differentiation; bde induced ... See more keywords
Optimising genetic transformation of Trypanosoma cruzi using hydroxyurea-induced cell-cycle synchronisation
Sign Up to like & getrecommendations! Published in 2018 at "Molecular and Biochemical Parasitology"
DOI: 10.1016/j.molbiopara.2018.07.002
Abstract: Highlights • A straightforward method for optimising Trypanosoma cruzi transfection efficiency.• Facilitated by hydroxyurea-induced cell-cycle synchronization.• Applicable to both episomal and integrative-mediated transformation.• Reduces the time required to generate genetically modified cell lines.• Increases the… read more here.
Keywords: cell cycle; hydroxyurea induced; cell; trypanosoma cruzi ... See more keywords
Globular adiponectin protects hepatocytes from tunicamycin‐induced cell death via modulation of the inflammasome and heme oxygenase‐1 induction
Sign Up to like & getrecommendations! Published in 2018 at "Pharmacological Research"
DOI: 10.1016/j.phrs.2017.10.010
Abstract: &NA; Endoplasmic reticulum (ER) stress, which is defined as the accumulation of unfolded or misfolded proteins in the ER, triggers cellular dysfunction and eventually leads to cell death. In particular, excessive and prolonged ER stress… read more here.
Keywords: induced cell; tunicamycin induced; cell death;
Identification of Novel Oxindole Compounds That Suppress ER Stress-Induced Cell Death as Chemical Chaperones.
Sign Up to like & getrecommendations! Published in 2022 at "ACS chemical neuroscience"
DOI: 10.1021/acschemneuro.2c00064
Abstract: Endoplasmic reticulum (ER) stress and oxidative stress lead to protein misfolding, and the resulting accumulation of protein aggregates is often associated with the pathogenesis of neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis,… read more here.
Keywords: stress; gif; induced cell; stress induced ... See more keywords
NKILA lncRNA promotes tumor immune evasion by sensitizing T cells to activation-induced cell death
Sign Up to like & getrecommendations! Published in 2018 at "Nature Immunology"
DOI: 10.1038/s41590-018-0207-y
Abstract: Activation-induced cell death (AICD) of T lymphocytes can be exploited by cancers to escape immunological destruction. We demonstrated that tumor-specific cytotoxic T lymphocytes (CTLs) and type 1 helper T (TH1) cells, rather than type 2… read more here.
Keywords: cell; activation induced; induced cell; cell death ... See more keywords