Metabolomics analysis highlights Yashtimadhu (Glycyrrhiza glabra L.)‐mediated neuroprotection in a rotenone‐induced cellular model of Parkinson's disease by restoring the mTORC1‐AMPK1 axis in autophagic regulation
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DOI: 10.1002/ptr.7449
Abstract: Parkinson's disease (PD) is an age‐associated progressive neurodegenerative movement disorder, and its management strategies are known to cause complications with prolonged usage. We aimed to explore the neuroprotective mechanism of the Indian traditional medicine Yashtimadhu,… read more here.
Keywords: induced cellular; rotenone induced; cellular model; analysis ... See more keywords
EF‐24 inhibits TPA‐induced cellular migration and MMP‐9 expression through the p38 signaling pathway in cervical cancer cells
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DOI: 10.1002/tox.23709
Abstract: Diphenyl difluoroketone (EF‐24), a synthetic curcumin analog, has enhanced bioavailability over curcumin. EF‐24 acts more powerful bioactivity for anti‐inflammatory and anti‐cancer activity. However, the effects and mechanism of EF‐24 on cervical cancer has not been… read more here.
Keywords: cervical cancer; induced cellular; tpa induced; cellular migration ... See more keywords
Resveratrol attenuates cigarette smoke extract induced cellular senescence in human airway epithelial cells by regulating the miR-34a/SIRT1/NF-κB pathway
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DOI: 10.1097/md.0000000000031944
Abstract: Chronic obstructive pulmonary disease (COPD) is characterized by accelerated lung aging. Smoking is the critical risk factor for COPD. Cellular senescence of airway epithelial cells is the cytological basis of accelerated lung aging in COPD,… read more here.
Keywords: induced cellular; senescence; cellular senescence; mir 34a ... See more keywords
GRWD1-WDR5-MLL2 Epigenetic Complex Mediates H3K4me3 Mark and Is Essential for Kaposi’s Sarcoma-Associated Herpesvirus-Induced Cellular Transformation
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DOI: 10.1128/mbio.03431-21
Abstract: By performing a genome-wide CRISPR-Cas9 screening, we have identified cellular epigenetic regulators that are essential for KSHV-induced cellular transformation. Among them, GRWD1 regulates epigenetic active mark H3K4me3 by interacting with WDR5 and MLL2 and recruiting… read more here.
Keywords: induced cellular; mark; cellular transformation; kshv ... See more keywords
Hypercholesterolemia Negatively Regulates P2X7-Induced Cellular Function in CD4+ and CD8+ T-Cell Subsets from B6 Mice Fed a High-Fat Diet
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DOI: 10.3390/ijms23126730
Abstract: We have previously showed that plasma membrane cholesterol and GM1 ganglioside content are responsible for the opposite sensitivity of mouse leukemic T cells to ATP. We also reported that the sensitivity of CD4+ and CD8+… read more here.
Keywords: induced cellular; cd4 cd8; p2x7 induced; p2x7 ... See more keywords