Inhibition and Rescue of Hyperglycemia‐Induced Cellular Senescence by Mitochondrial Transfer from Enucleated Mesenchymal Stem Cell‐Derived Microvesicles for Chronic Wound Healing
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DOI: 10.1002/advs.202501612
Abstract: The aberrant cellular senescence in chronic wounds presents a significant barrier to healing. Mitochondrial dysfunction is critical in initiating and maintaining cellular senescence, underscoring therapeutic potential in restoring mitochondrial function by delivering healthy mitochondria to… read more here.
Keywords: senescence; induced cellular; cellular senescence; mito eumvs ... See more keywords
Metabolomics analysis highlights Yashtimadhu (Glycyrrhiza glabra L.)‐mediated neuroprotection in a rotenone‐induced cellular model of Parkinson's disease by restoring the mTORC1‐AMPK1 axis in autophagic regulation
Sign Up to like & getrecommendations! Published in 2022 at "Phytotherapy Research"
DOI: 10.1002/ptr.7449
Abstract: Parkinson's disease (PD) is an age‐associated progressive neurodegenerative movement disorder, and its management strategies are known to cause complications with prolonged usage. We aimed to explore the neuroprotective mechanism of the Indian traditional medicine Yashtimadhu,… read more here.
Keywords: induced cellular; rotenone induced; cellular model; analysis ... See more keywords
EF‐24 inhibits TPA‐induced cellular migration and MMP‐9 expression through the p38 signaling pathway in cervical cancer cells
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DOI: 10.1002/tox.23709
Abstract: Diphenyl difluoroketone (EF‐24), a synthetic curcumin analog, has enhanced bioavailability over curcumin. EF‐24 acts more powerful bioactivity for anti‐inflammatory and anti‐cancer activity. However, the effects and mechanism of EF‐24 on cervical cancer has not been… read more here.
Keywords: cervical cancer; induced cellular; tpa induced; cellular migration ... See more keywords
Radiation-induced cellular plasticity primes glioblastoma for forskolin-mediated differentiation
Sign Up to like & getrecommendations! Published in 2025 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2415557122
Abstract: Significance The distinctive nature of glioblastoma (GBM) and the blood–brain barrier (BBB) are obstacles for therapies that aim to permanently stop glioma cells from dividing. Similar to reprogramming normal cells, “differentiation therapies” try to push… read more here.
Keywords: differentiation; induced cellular; radiation; radiation induced ... See more keywords
Resveratrol attenuates cigarette smoke extract induced cellular senescence in human airway epithelial cells by regulating the miR-34a/SIRT1/NF-κB pathway
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DOI: 10.1097/md.0000000000031944
Abstract: Chronic obstructive pulmonary disease (COPD) is characterized by accelerated lung aging. Smoking is the critical risk factor for COPD. Cellular senescence of airway epithelial cells is the cytological basis of accelerated lung aging in COPD,… read more here.
Keywords: induced cellular; senescence; cellular senescence; mir 34a ... See more keywords
When therapy-induced senescence meets tumors: A double-edged sword: A review
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DOI: 10.1097/md.0000000000042886
Abstract: The tumor microenvironment (TME) significantly influences tumor development, progression, and clinical outcomes. Therapy-induced cellular senescence is a fundamental process affecting the microenvironment. This review summarizes the characteristics of therapy-induced cellular senescence, its beneficial and detrimental… read more here.
Keywords: senescence; induced cellular; cellular senescence; therapy induced ... See more keywords
GRWD1-WDR5-MLL2 Epigenetic Complex Mediates H3K4me3 Mark and Is Essential for Kaposi’s Sarcoma-Associated Herpesvirus-Induced Cellular Transformation
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DOI: 10.1128/mbio.03431-21
Abstract: By performing a genome-wide CRISPR-Cas9 screening, we have identified cellular epigenetic regulators that are essential for KSHV-induced cellular transformation. Among them, GRWD1 regulates epigenetic active mark H3K4me3 by interacting with WDR5 and MLL2 and recruiting… read more here.
Keywords: induced cellular; mark; cellular transformation; kshv ... See more keywords
Glucose-Induced Cellular Morphological Changes Across Mammalian Species
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DOI: 10.1152/physiol.2024.39.s1.2098
Abstract: All organisms encounter environmental fluctuations and must contend with these changes to maintain homeostasis. Some mammals tolerate a wide range of intracellular conditions while others do not. Altered glucose levels are an example of a… read more here.
Keywords: induced cellular; physiology; cellular morphological; morphological changes ... See more keywords
Unveiling the impact of non-coding RNAs on virus-induced cellular autophagy: roles and research advances
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DOI: 10.3389/fmicb.2025.1632425
Abstract: Autophagy is the process by which cells degrade and recycle damaged organelles and macromolecules by forming autophagosomes. This process is closely related to the maintenance of cellular homeostasis, ontogeny, and the occurrence and development of… read more here.
Keywords: non coding; induced cellular; coding rnas; virus induced ... See more keywords
Hypercholesterolemia Negatively Regulates P2X7-Induced Cellular Function in CD4+ and CD8+ T-Cell Subsets from B6 Mice Fed a High-Fat Diet
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23126730
Abstract: We have previously showed that plasma membrane cholesterol and GM1 ganglioside content are responsible for the opposite sensitivity of mouse leukemic T cells to ATP. We also reported that the sensitivity of CD4+ and CD8+… read more here.
Keywords: induced cellular; cd4 cd8; p2x7 induced; p2x7 ... See more keywords