Low-dose hydralazine improves endotoxin-induced coagulopathy and multiple organ dysfunction via its anti-inflammatory and anti-oxidative/nitrosative properties.
Sign Up to like & getrecommendations! Published in 2020 at "European journal of pharmacology"
DOI: 10.1016/j.ejphar.2020.173279
Abstract: Coagulopathy is the major cause of organ injury as well as a strong predictor of mortality in septic patients. Systemic inflammatory response and redox imbalance are regarded as the major causes of sepsis-induced coagulopathy. There… read more here.
Keywords: dose hydralazine; low dose; organ dysfunction; induced coagulopathy ... See more keywords
Study on coagulation profiles and platelet function in trauma-induced coagulopathy caused by three types of injury.
Sign Up to like & getrecommendations! Published in 2020 at "Injury"
DOI: 10.1016/j.injury.2020.02.081
Abstract: BACKGROUND Traumatic coagulopathy is a major public health issue globally with undefined mechanisms. We established rat models of hemorrhagic shock (HS), multiple injury (MI) and traumatic brain injury (TBI) to investigate the diversity of traumatic… read more here.
Keywords: mi3h; control; inhibition; hs3h ... See more keywords
Trauma-induced coagulopathy
Sign Up to like & getrecommendations! Published in 2021 at "Nature Reviews Disease Primers"
DOI: 10.1038/s41572-021-00270-5
Abstract: This PrimeView highlights the complex interactions between both prothrombotic and antithrombotic mechanisms that underlie trauma-induced coagulopathy. read more here.
Keywords: induced coagulopathy; trauma induced;
Methods to Correct Drug-Induced Coagulopathy in Bleeding Emergencies: A Comparative Review.
Sign Up to like & getrecommendations! Published in 2022 at "Laboratory medicine"
DOI: 10.1093/labmed/lmab115
Abstract: OBJECTIVE Anticoagulant and antiplatelet therapy have become increasingly popular. The goal of therapy is to prevent venous thromboembolism and platelet aggregation, respectively. Traditional anticoagulant and antiplatelet drugs are quickly being replaced with novel medications with… read more here.
Keywords: review; drug; induced coagulopathy; medicine ... See more keywords
Understanding Extracorporeal Membrane Oxygenation Induced Coagulopathy: Many Pieces to the Puzzle.
Sign Up to like & getrecommendations! Published in 2020 at "Critical Care Medicine"
DOI: 10.1097/ccm.0000000000004370
Abstract: To the Editor: We read with interest the article by Granja et al (1), published in the recent issue of Critical Care Medicine, on multi-modal characterization of extracorporeal membrane oxygenation (ECMO)-induced coagulopathy (EIC). The authors’… read more here.
Keywords: induced coagulopathy; medicine; membrane oxygenation; study ... See more keywords
Early haemorrhage control and management of trauma-induced coagulopathy: the importance of goal-directed therapy
Sign Up to like & getrecommendations! Published in 2017 at "Current Opinion in Critical Care"
DOI: 10.1097/mcc.0000000000000466
Abstract: Purpose of review The aim of this study was to discuss the recent developments in trauma-induced coagulopathy and the evolvement of goal-directed therapy. Recent findings Mortality from major trauma continues to be a worldwide problem,… read more here.
Keywords: directed therapy; trauma; trauma induced; goal directed ... See more keywords
Role of Fibrinogen in Trauma-Induced Coagulopathy.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of the American College of Surgeons"
DOI: 10.1097/xcs.0000000000000078
Abstract: BACKGROUND Fibrinogen is the first coagulation factor to decrease after massive hemorrhage. European massive transfusion guidelines recommend early repletion of fibrinogen; however, this practice has not been widely adopted in the US. We hypothesize that… read more here.
Keywords: role fibrinogen; trauma induced; induced coagulopathy; fibrinogen ... See more keywords
French lyophilized plasma versus fresh frozen plasma for the initial management of trauma‐induced coagulopathy: a randomized open‐label trial
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Thrombosis and Haemostasis"
DOI: 10.1111/jth.13929
Abstract: Essentials An immediate supply of plasma in case of trauma‐induced coagulopathy is required. The Traucc trial compared French Lyophilised Plasma (FLyP) and Fresh Frozen Plasma (FFP). FLyP achieved higher fibrinogen concentrations compared with FFP. FLyP… read more here.
Keywords: plasma; frozen plasma; fresh frozen; trauma induced ... See more keywords
Response to Letter to the Editor submitted by Dr. Wada and Dr. Yamakawa re: Trauma‐induced coagulopathy: The past, present, and future
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Thrombosis and Haemostasis"
DOI: 10.1111/jth.14581
Abstract: It is with equal appreciation and enthusiasm that we have the opportunity to participate in these valuable scientific discussions with our respected colleagues Dr. Wada and Dr. Yamakawa, as we did with Dr. Gando and… read more here.
Keywords: wada yamakawa; induced coagulopathy; trauma induced; response ... See more keywords
Evaluation of trauma‐induced coagulopathy in the fibrinogen in the initial resuscitation of severe trauma trial
Sign Up to like & getrecommendations! Published in 2021 at "Transfusion"
DOI: 10.1111/trf.16488
Abstract: Coagulopathic bleeding is frequently present after major trauma. However, trauma‐induced coagulopathy (TIC) remains incompletely understood. This laboratory analysis of blood samples derived from our completed trial on fibrinogen in the initial resuscitation of severe trauma… read more here.
Keywords: fibrinogen initial; initial resuscitation; trauma; trauma induced ... See more keywords
The Value of Thromboelastography in the Diagnosis of Sepsis-Induced Coagulopathy
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DOI: 10.1177/1076029620951847
Abstract: Thromboelastography (TEG) is regularly used for monitoring abnormalities of the coagulation system in patients with sepsis. However, it is unclear whether TEG parameters are associated with sepsis-induced coagulopathy (SIC). Thus, we aimed to assess the… read more here.
Keywords: sepsis; sepsis group; value; thromboelastography ... See more keywords