RTA‐408 protects against propofol‐induced cognitive impairment in neonatal mice via the activation of Nrf2 and the inhibition of NF‐κB p65 nuclear translocation
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DOI: 10.1002/brb3.1918
Abstract: To explore the effect of RTA‐408 on the propofol‐induced cognitive impairment of neonatal mice via regulating Nrf2 and NF‐κB p65 nuclear translocation. read more here.
Keywords: rta 408; propofol induced; induced cognitive; cognitive impairment ... See more keywords
Exogenous recombinant Hsp70 attenuates sevoflurane anesthesia‐induced cognitive dysfunction in aged mice
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DOI: 10.1002/brb3.2861
Abstract: Postoperative cognitive dysfunction (POCD) is a severe postoperative neurological sequela in elderly patients, and there is currently no standard treatment for POCD. In this study, whether recombinant human heat shock protein 70 (rHsp70) could alleviate… read more here.
Keywords: cognitive dysfunction; induced cognitive; aged mice; exogenous recombinant ... See more keywords
JNK‐IN‐8 treatment improves ARDS‐induced cognitive impairment by inhibiting JNK/NF‐κB‐mediated NLRP3 inflammasome
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DOI: 10.1002/brb3.2980
Abstract: Cognitive impairment is a critical complication of acute respiratory distress syndrome (ARDS). However, effective interventions are lacking. Growing evidence demonstrates that c‐Jun N‐terminal kinase (JNK)‐mediated neuroinflammation is involved in the development of ARDS. Therefore, we… read more here.
Keywords: jnk mediated; induced cognitive; cognitive impairment; jnk ... See more keywords
Enriched environment ameliorates postsurgery sleep deprivation-induced cognitive impairments through the AMPA receptor GluA1 subunit.
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DOI: 10.1002/brb3.2992
Abstract: BACKGROUND As a common postsurgery complication, sleep deprivation (SD) can severely deteriorate the cognitive function of patients. Enriched environment (EE) exposure can increase children's cognitive ability, and whether EE exposure could be utilized to alleviate… read more here.
Keywords: enriched environment; induced cognitive; sleep deprivation; cognitive impairments ... See more keywords
Neuroprotective effects of 20(S)‐protopanaxatriol (PPT) on scopolamine‐induced cognitive deficits in mice
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DOI: 10.1002/ptr.6044
Abstract: 20(S)‐protopanaxatriol (PPT), one of the ginsenosides from Panax ginseng, has been reported to have neuroprotective effects and to improve memory. The present study was designed to investigate the protective effect of PPT on scopolamine‐induced cognitive… read more here.
Keywords: scopolamine; neuroprotective effects; protopanaxatriol ppt; induced cognitive ... See more keywords
Tenuifolin ameliorates the sleep deprivation‐induced cognitive deficits
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DOI: 10.1002/ptr.7627
Abstract: Tenuifolin (TEN), a natural neuroprotective compound obtained from the Polygala tenuifolia Willd plant, has improved cognitive symptoms. However, the impact of TEN on memory impairments caused by sleep deprivation (SD) is unclear. Accordingly, the objective… read more here.
Keywords: deprivation induced; induced cognitive; sleep deprivation; deprivation ... See more keywords
Role of inflammatory, oxidative, and ER stress signaling in the neuroprotective effect of atorvastatin against doxorubicin-induced cognitive impairment in rats.
Sign Up to like & getrecommendations! Published in 2021 at "Naunyn-Schmiedeberg's archives of pharmacology"
DOI: 10.1007/s00210-021-02081-7
Abstract: Doxorubicin (DOX) is a potent chemotherapeutic agent widely used for the treatment of several malignancies. Despite its effectiveness, DOX has been implicated in induced neurotoxicity manifested as cognitive dysfunction with varying degrees, commonly referred to… read more here.
Keywords: dox induced; induced cognitive; cognitive impairment; dox ... See more keywords
The neuroprotective effect and action mechanism of polyphenols in diabetes mellitus-related cognitive dysfunction
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DOI: 10.1007/s00394-019-02078-2
Abstract: Background Diabetes mellitus (DM) is a complex and prevalent metabolic disorder worldwide. Strong evidence has emerged that DM is a risk factor for the accelerated rate of cognitive decline and the development of dementia. Though… read more here.
Keywords: dysfunction; induced cognitive; related cognitive; cognitive dysfunction ... See more keywords
Legumain acts on neuroinflammatory to affect CUS-induced cognitive impairment
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DOI: 10.1016/j.bbr.2019.112219
Abstract: Cognitive impairment has been widely recognized as a central feature of depression. Legumain, a lysosomal cysteine protease, plays an important role in cancer, atherosclerosis, inflammation and other pathological conditions. Meanwhile, it has been reported that… read more here.
Keywords: legumain; cognitive impairment; cus induced; induced cognitive ... See more keywords
A complement-microglial axis driving inhibitory synapse related protein loss might contribute to systemic inflammation-induced cognitive impairment.
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DOI: 10.1016/j.intimp.2020.106814
Abstract: Systemic inflammation induces cognitive impairments via unclear mechanisms. Increasing evidence has suggested complement C3/C3a receptor signaling, a key component of innate immune pathogen defense, plays an important role in cognition and neurodegeneration, whereas its dysfunction… read more here.
Keywords: c3a receptor; synapse related; inflammation; induced cognitive ... See more keywords
Kai Xin San aqueous extract improves Aβ1-40-induced cognitive deficits on adaptive behavior learning by enhancing memory-related molecules expression in the hippocampus.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of ethnopharmacology"
DOI: 10.1016/j.jep.2016.10.002
Abstract: ETHNOPHARMACOLOGICAL RELEVANCE Kai Xin San (KXS), a traditional formula of Chinese medicine, has been used to treat dementia. AIM OF THE STUDY The present study aimed to investigate its ameliorating effects on Aβ1-40-induced cognitive impairment… read more here.
Keywords: induced cognitive; xin san; kai xin; aqueous extract ... See more keywords