PEG vs. sennosides for opioid-induced constipation in cancer care
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DOI: 10.1007/s00520-019-04944-5
Abstract: Purpose This randomized double-blind, double-dummy, 2-treatment, 2-period crossover study aimed to compare the efficacy and tolerability of polyethylene glycol (PEG) and sennosides in ambulatory cancer patients with opioid-induced constipation. Methods Outpatients ≥ 18 years old with cancer,… read more here.
Keywords: peg sennosides; induced constipation; treatment; opioid induced ... See more keywords
Probiotics decrease depressive behaviors induced by constipation via activating the AKT signaling pathway
Sign Up to like & getrecommendations! Published in 2018 at "Metabolic Brain Disease"
DOI: 10.1007/s11011-018-0269-4
Abstract: Chronic constipation is often accompanied by emotional disorders such as depression and anxiety. The aim of this study was to determine whether administration of a multispecies probiotic can decrease depressive behaviors through the gut-brain axis… read more here.
Keywords: induced constipation; akt signaling; depressive behaviors; decrease depressive ... See more keywords
When People with Opioid-Induced Constipation Speak: A Patient Survey
Sign Up to like & getrecommendations! Published in 2017 at "Advances in Therapy"
DOI: 10.1007/s12325-017-0480-4
Abstract: IntroductionOpioid-induced constipation (OIC) is a common consequence of opioid use for chronic pain. OIC creates problems for patients independent of their pain syndromes, in addition to threatening pain treatment effectiveness. Healthcare practitioners need to be… read more here.
Keywords: text responses; symptom relief; survey; induced constipation ... See more keywords
Naldemedine: A Review in Opioid-Induced Constipation
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DOI: 10.1007/s40265-019-01160-7
Abstract: Naldemedine [Symproic® (Japan; USA); Rizmoic® (EU)], an orally available peripherally acting μ-opioid receptor antagonist (PAMORA), is approved in several countries for the treatment of opioid-induced constipation. In phase III trials, naldemedine was more effective than… read more here.
Keywords: induced constipation; cancer pain; naldemedine; opioid induced ... See more keywords
Polysaccharide from Spirulina platensis ameliorates diphenoxylate-induced constipation symptoms in mice.
Sign Up to like & getrecommendations! Published in 2019 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2019.04.209
Abstract: The aim of this study is to probe new functions of a polysaccharide from Spirulina platensis (PSP) on constipation and intestinal microbiota in mice. Diphenoxylate-induced constipation in mice was treated with different doses of PSP,… read more here.
Keywords: diphenoxylate induced; induced constipation; polysaccharide spirulina; psp ... See more keywords
Effect of Konjac mannan oligosaccharides on diphenoxylate-induced constipation in mice
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Functional Foods"
DOI: 10.1016/j.jff.2019.04.036
Abstract: Abstract The effects of Konjac mannan oligosaccharides (KMOS) on diphenoxylate-induced constipation in mice were investigated in the present study. After administration with KMOS at 1800 mg/kg·bw, the weight and number of black feces within 24 h, and… read more here.
Keywords: constipation; induced constipation; mannan oligosaccharides; konjac mannan ... See more keywords
Patient-Reported Outcomes of Opioid-Induced Constipation as Identified Through Social Media
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DOI: 10.1016/j.jval.2017.08.1447
Abstract: Opioid-induced constipation (OIC) is the most common adverse effect associated with prolonged use of opioids; it has been estimated that between 40% and 95% of patients develop OIC (Kumar et al, 2014). OIC is persistent,… read more here.
Keywords: reported outcomes; induced constipation; opioid induced; outcomes opioid ... See more keywords
Rational Design, Chemical Syntheses, and Biological Evaluations of Peripherally Selective Mu Opioid Receptor Ligands as Potential Opioid Induced Constipation Treatment.
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DOI: 10.1021/acs.jmedchem.1c02185
Abstract: Opioid-induced constipation (OIC) is a common adverse effect of opioid analgesics. Peripherally acting μ opioid receptor antagonists (PAMORAs) can be applied in the treatment of OIC without compromising the analgesic effects. NAP, a 6β-N-4-pyridyl-substituted naltrexamine… read more here.
Keywords: induced constipation; opioid receptor; opioid induced; opioid ... See more keywords
Methylnaltrexone bromide for the treatment of opioid-induced constipation
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DOI: 10.1080/14656566.2018.1491549
Abstract: ABSTRACT Introduction: The extensive and alarming use of opioids for pain management in patients with chronic pain receiving palliative care is associated with non-tolerable gastrointestinal (GI) adverse effects. Opioid-induced constipation (OIC) is the most common… read more here.
Keywords: methylnaltrexone bromide; induced constipation; treatment; opioid induced ... See more keywords
Onset of action of naldemedine in the treatment of opioid-induced constipation in patients with chronic noncancer pain: results from 2 randomized, placebo-controlled, phase 3 trials
Sign Up to like & getrecommendations! Published in 2019 at "Pain"
DOI: 10.1097/j.pain.0000000000001629
Abstract: Naldemedine improves opioid-induced constipation in a timely manner in patients using opioids for noncancer pain; most experienced spontaneous bowel movement within 24 hours of treatment. read more here.
Keywords: induced constipation; treatment; noncancer pain; onset action ... See more keywords
Acupuncture for opioid-induced constipation
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DOI: 10.1097/md.0000000000023352
Abstract: Abstract Background: Opioid-induced constipation (OIC) is one of the most common complications of analgesic therapy for cancer pain patients who suffer moderate to severe pain. Acupuncture as an effective treatment in constipation has been widely… read more here.
Keywords: constipation; opioid induced; treatment; induced constipation ... See more keywords