Downregulation of lncRNA ANRIL represses tumorigenicity and enhances cisplatin‐induced cytotoxicity via regulating microRNA let‐7a in nasopharyngeal carcinoma
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Biochemical and Molecular Toxicology"
DOI: 10.1002/jbt.21904
Abstract: Many studies have demonstrated that upregulation of long non‐coding RNA (lncRNA) antisense non‐coding RNA in the INK4 locus (ANRIL) plays an oncogenic role in various tumors, including nasopharyngeal carcinoma (NPC). The aim of this study… read more here.
Keywords: anril; anril represses; induced cytotoxicity; let ... See more keywords
Molecular insights of 2,6‐dichlorobenzoquinone‐induced cytotoxicity in zebrafish embryo: Activation of ROS‐mediated cell cycle arrest and apoptosis
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DOI: 10.1002/tox.23721
Abstract: 2,6‐dichloro‐1,4‐benzoquinone (2,6‐DCBQ), as an emerging disinfection by‐product, has been frequently detected in waters, posing potential health risk on public health. Although some studies have pointed out that 2,6‐DCBQ exposure can induce cytotoxicity, limited information is… read more here.
Keywords: induced cytotoxicity; cell; cell cycle; apoptosis ... See more keywords
Protective effect of catechin on pentachlorophenol-induced cytotoxicity and genotoxicity in isolated human blood cells
Sign Up to like & getrecommendations! Published in 2020 at "Environmental Science and Pollution Research"
DOI: 10.1007/s11356-020-07969-0
Abstract: Pentachlorophenol (PCP) is an organochlorine compound that is used as pesticide, biocide, and wood preservative. PCP is highly toxic and carcinogenic. It has been detected in food and several consumable products. The toxicity of PCP… read more here.
Keywords: cytotoxicity genotoxicity; pcp induced; catechin; induced cytotoxicity ... See more keywords
Effects of asarinin on dopamine biosynthesis and 6-hydroxydopamine-induced cytotoxicity in PC12 cells
Sign Up to like & getrecommendations! Published in 2017 at "Archives of Pharmacal Research"
DOI: 10.1007/s12272-017-0908-z
Abstract: This study investigated the effects of asarinin on dopamine biosynthesis and 6-hydroxydopamine (6-OHDA)-induced cytotoxicity in rat adrenal pheochromocytoma (PC12) cells. Treatment with asarinin (25–50 μM) increased intracellular dopamine levels and enhanced L-DOPA-induced increases in dopamine levels.… read more here.
Keywords: effects asarinin; dopamine biosynthesis; pc12 cells; induced cytotoxicity ... See more keywords
Leonurine protects against dexamethasone-induced cytotoxicity in pancreatic β-cells via PI3K/Akt signaling pathway.
Sign Up to like & getrecommendations! Published in 2020 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2020.05.184
Abstract: Glucocorticoid excess induces pancreatic β-cell apoptosis and insulin secretion impairment, which may lead to hyperglycemia and steroid diabetes. Leonurine is a natural alkaloid extracted from the Herba leonuri, which has been widely used in the… read more here.
Keywords: dexamethasone induced; pancreatic cells; induced cytotoxicity; dexamethasone ... See more keywords
Zinc-pretreatment triggers glutathione and Nrf2-mediated protection against inorganic mercury-induced cytotoxicity and intrinsic apoptosis in PC12 cells.
Sign Up to like & getrecommendations! Published in 2020 at "Ecotoxicology and environmental safety"
DOI: 10.1016/j.ecoenv.2020.111320
Abstract: Mercury (Hg) is a hazardous metal, poses environmental problems with severe human health effects; whereas zinc (Zn) is an essential micronutrient with antioxidant properties. The purpose of this research was to investigate the effect of… read more here.
Keywords: cell; pc12 cells; apoptosis; induced cytotoxicity ... See more keywords
Atorvastatin protected from paraquat-induced cytotoxicity in alveolar macrophages via down-regulation of TLR-4.
Sign Up to like & getrecommendations! Published in 2017 at "Environmental toxicology and pharmacology"
DOI: 10.1016/j.etap.2016.11.011
Abstract: The current study designed to clarify the mechanism of paraquat-induced cytotoxicity and protective effects of Atorvastatin on freshly isolated alveolar macrophages (AMs). AMs were collected via bronchoalveolar lavage and exposed to various concentrations of paraquat… read more here.
Keywords: alveolar macrophages; paraquat; tlr; induced cytotoxicity ... See more keywords
Ferroptosis contributes to methylmercury-induced cytotoxicity in rat primary astrocytes and Buffalo rat liver cells.
Sign Up to like & getrecommendations! Published in 2022 at "Neurotoxicology"
DOI: 10.1016/j.neuro.2022.04.006
Abstract: OBJECTIVE Ferroptosis is an iron-dependent nonapoptotic form of cell death, characterized by iron accumulation and lipid peroxidation. However, the role of ferroptosis in methylmercury (MeHg)-induced cytotoxicity has yet to be fully characterized. The purpose of… read more here.
Keywords: cytotoxicity; mehg induced; liver; ferroptosis ... See more keywords
Betanin reduces organophosphate induced cytotoxicity in primary hepatocyte via an anti-oxidative and mitochondrial dependent pathway.
Sign Up to like & getrecommendations! Published in 2018 at "Pesticide biochemistry and physiology"
DOI: 10.1016/j.pestbp.2017.11.009
Abstract: Organophosphates (OP) are potent pesticide commonly utilized in agricultural and domestic use. However, plentitude of data represent their side effects in different body tissues. We attempted to study whether betanin (a natural pigment) is able… read more here.
Keywords: betanin reduces; ros formation; betanin; organophosphate induced ... See more keywords
Thiram-induced cytotoxicity and oxidative stress in human erythrocytes: an in vitro study.
Sign Up to like & getrecommendations! Published in 2020 at "Pesticide biochemistry and physiology"
DOI: 10.1016/j.pestbp.2019.12.003
Abstract: Tetramethylthiuram disulfide, commonly known as thiram, is an organosulfur compound which is used as a bactericide, fungicide and ectoparasiticide to prevent disease in seeds and crops. Being a fungicide there is a high probability of… read more here.
Keywords: thiram; induced cytotoxicity; human erythrocytes; thiram induced ... See more keywords
lncRNA involved in triptonide-induced cytotoxicity in mouse germ cells.
Sign Up to like & getrecommendations! Published in 2020 at "Reproductive toxicology"
DOI: 10.1016/j.reprotox.2020.10.004
Abstract: Triptonide reportedly has strong antitumor and anti-inflammatory activities. However, its severe toxicity, including to the reproductive system, has greatly restricted its use in patients who wish to preserve fertility. lncRNAs play crucial roles in male… read more here.
Keywords: triptonide induced; cell; germ cells; induced cytotoxicity ... See more keywords