Lineage tracing reveals dynamic changes in oligodendrocyte precursor cells following cuprizone‐induced demyelination
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DOI: 10.1002/glia.23229
Abstract: The regeneration of oligodendrocytes is a crucial step in recovery from demyelination, as surviving oligodendrocytes exhibit limited structural plasticity and rarely form additional myelin sheaths. New oligodendrocytes arise through the differentiation of platelet‐derived growth factor… read more here.
Keywords: induced demyelination; demyelination; matter; gray matter ... See more keywords
Deletion of Nox4 enhances remyelination following cuprizone‐induced demyelination by increasing phagocytic capacity of microglia and macrophages in mice
Sign Up to like & getrecommendations! Published in 2022 at "Glia"
DOI: 10.1002/glia.24292
Abstract: NOX4 is a major reactive oxygen species‐producing enzyme that modulates cell stress responses. We here examined the effect of Nox4 deletion on demyelination–remyelination, the most common pathological change in the brain. We used a model… read more here.
Keywords: deletion; nox4 mice; remyelination; induced demyelination ... See more keywords
Microglia polarization by methylprednizolone acetate accelerates cuprizone induced demyelination
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Molecular Histology"
DOI: 10.1007/s10735-018-9786-z
Abstract: Glucocorticoids (GC) are known as inflammatory drugs, which are used in neuroinflammatory diseases. Unlike the classic picture, recent studies have revealed that some GC drugs exacerbate inflammatory responses in their acute and prolonged administration. Multiple… read more here.
Keywords: induced demyelination; demyelination; cuprizone; cpz ... See more keywords
Neuroprotective Effects of Telmisartan and Nifedipine Against Cuprizone-Induced Demyelination and Behavioral Dysfunction in Mice: Roles of NF-κB and Nrf2.
Sign Up to like & getrecommendations! Published in 2021 at "Inflammation"
DOI: 10.1007/s10753-021-01447-6
Abstract: Multiple sclerosis is a chronic inflammatory neurodegenerative disease of the central nervous system which injures the myelin sheath. Telmisartan and nifedipine are antihypertensive drugs that recently showed neuroprotective properties against neurodegenerative diseases. This study evaluated… read more here.
Keywords: induced demyelination; cuprizone; telmisartan nifedipine; cuprizone induced ... See more keywords
Formyl Peptide Receptor 1-Mediated Glial Cell Activation in a Mouse Model of Cuprizone-Induced Demyelination
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DOI: 10.1007/s12031-017-0924-y
Abstract: Multiple sclerosis (MS) is a chronic degenerative disease of the central nervous system that is characterized by myelin abnormalities, oligodendrocyte pathology, and concomitant glia activation. Unclear are the factors triggering gliosis and demyelination. New findings… read more here.
Keywords: induced demyelination; demyelination; cuprizone; glial cell ... See more keywords
Sulfasalazine alters microglia phenotype by competing endogenous RNA effect of miR‐136‐5p and long non‐coding RNA HOTAIR in cuprizone‐induced demyelination
Sign Up to like & getrecommendations! Published in 2018 at "Biochemical Pharmacology"
DOI: 10.1016/j.bcp.2018.06.028
Abstract: Graphical abstract Figure. No caption available. &NA; Sulfasalazine (SF) promotes remyelination and improves the outcome of multiple sclerosis (MS) patients. However, the underlining mechanism remains elusive. Here, we examined whether SF blocks microglia switching to… read more here.
Keywords: induced demyelination; cuprizone; hotair; cuprizone induced ... See more keywords
Prednisone alleviates demyelination through regulation of the NLRP3 inflammasome in a C57BL/6 mouse model of cuprizone-induced demyelination
Sign Up to like & getrecommendations! Published in 2018 at "Brain Research"
DOI: 10.1016/j.brainres.2017.09.034
Abstract: Myelin abnormalities, oligodendrocyte damage, and concomitant glia activation are common in demyelinating diseases of the central nervous system (CNS). Increasing evidence has demonstrated that the inflammatory response triggers demyelination and gliosis in demyelinating disorders. Numerous… read more here.
Keywords: pdn; induced demyelination; demyelination; cuprizone ... See more keywords
Cuprizone‐induced demyelination in the mouse hippocampus is alleviated by phytoestrogen genistein
Sign Up to like & getrecommendations! Published in 2019 at "Toxicology and Applied Pharmacology"
DOI: 10.1016/j.taap.2018.11.009
Abstract: ABSTRACT One of the major female sex hormones, estrogen, can influence a variety of mental states. Individuals with multiple sclerosis (MS) often suffer from mental health issues, which are correlated with the pathology of gray… read more here.
Keywords: induced demyelination; phytoestrogen genistein; cpz; gen ... See more keywords
Ultrastructural mechanisms of macrophage-induced demyelination in CIDP
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DOI: 10.1212/wnl.0000000000006625
Abstract: Chronic inflammatory demyelinating polyneuropathy (CIDP) is a form of chronic neuropathy that is presumably caused by heterogeneous immune-mediated processes. Recent advances in the search for autoantibodies against components expressed at nodal regions, such as the… read more here.
Keywords: induced demyelination; demyelination; cidp; nodal regions ... See more keywords
Dapsone reduced cuprizone-induced demyelination via targeting Nrf2 and IKB in C57BL/6 mice
Sign Up to like & getrecommendations! Published in 2022 at "Iranian Journal of Basic Medical Sciences"
DOI: 10.22038/ijbms.2022.64993.14310
Abstract: Objective(s): Multiple Sclerosis (MS) is an inflammatory disorder wherein the myelin of nerve cells in the central nervous system is damaged. In the current study, we assessed the effect of Dapsone (DAP) on the improvement… read more here.
Keywords: cpz; nrf2 ikb; demyelination; targeting nrf2 ... See more keywords
Sex Differences in the Behavioural Aspects of the Cuprizone-Induced Demyelination Model in Mice
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DOI: 10.3390/brainsci12121687
Abstract: Multiple sclerosis is an autoimmune disease characterised by demyelination in the central nervous system. The cuprizone-induced demyelination model is often used in mice to test novel treatments for multiple sclerosis. However, despite significant demyelination, behavioural… read more here.
Keywords: cuprizone; demyelination; model; cuprizone induced ... See more keywords