Estimation of thermodynamic stability of human carbonic anhydrase IX from urea-induced denaturation and MD simulation studies.
Sign Up to like & getrecommendations! Published in 2017 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2017.07.010
Abstract: Carbonic anhydrase IX (CAIX) is a transmembrane glycoprotein, overexpressed in cancer cells under hypoxia condition. In cancerous cells, CAIX plays an important role to combat the deleterious effects of a high rate of glycolytic metabolism.… read more here.
Keywords: carbonic anhydrase; induced denaturation; denaturation; urea induced ... See more keywords
The Role of Cyclodextrins against Interface-Induced Denaturation in Pharmaceutical Formulations: A Molecular Dynamics Approach
Sign Up to like & getrecommendations! Published in 2021 at "Molecular Pharmaceutics"
DOI: 10.1021/acs.molpharmaceut.1c00135
Abstract: Protein-based pharmaceutical products are subject to a variety of environmental stressors, during both production and shelf-life. In order to preserve their structure, and, therefore, functionality, it is necessary to use excipients as stabilizing agents. Among… read more here.
Keywords: molecular dynamics; water; induced denaturation; denaturation ... See more keywords