The deleterious effect of stress‐induced depression on rat liver: Protective role of resveratrol and dimethyl fumarate via inhibiting the MAPK/ERK/JNK pathway
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Biochemical and Molecular Toxicology"
DOI: 10.1002/jbt.22627
Abstract: This study aimed to uncover the protective potentiality of resveratrol and dimethyl fumarate (DMF) in the liver of a chronic unpredictable mild stress (CUMS)‐induced depression animal model. Resveratrol and DMF significantly alleviated CUMS‐induced behavioral abnormalities… read more here.
Keywords: resveratrol; jnk; effect; resveratrol dimethyl ... See more keywords
Lacidipine attenuates reserpine-induced depression-like behavior and oxido-nitrosative stress in mice
Sign Up to like & getrecommendations! Published in 2019 at "Naunyn-Schmiedeberg's Archives of Pharmacology"
DOI: 10.1007/s00210-019-01667-6
Abstract: Depression is a serious medical illness displaying high lifetime prevalence, early-age onset that adversely affects socio-economic status. The bidirectional association between oxidative stress and calcium-signaling adversely affects the monoaminergic neuron functions that instigate the pathogenesis… read more here.
Keywords: depression; reserpine induced; stress; mice ... See more keywords
Physical exercise prevents mice from L-Kynurenine-induced depression-like behavior.
Sign Up to like & getrecommendations! Published in 2019 at "Asian journal of psychiatry"
DOI: 10.1016/j.ajp.2019.101894
Abstract: BACKGROUND Depression is a wide-spread disease that affects millions of people worldwide. Recent studies in neuroinflammation suggested that increased plasma kynurenine (KYN) level was related to depressive symptoms, while animal studies indicated that KYN increase… read more here.
Keywords: exercise prevents; like behavior; kyn; exercise ... See more keywords
Inhibitory Influence of Agmatine in Ethanol Withdrawal-Induced Depression in Rats: Behavioral and Neurochemical Evidences.
Sign Up to like & getrecommendations! Published in 2019 at "Alcohol"
DOI: 10.1016/j.alcohol.2019.09.002
Abstract: Although ethanol withdrawal depression is one of the prominent reasons for its reinstatement and dependence, its neurochemical basis is not clearly understood. Present study investigated the role of agmatinergic system in ethanol withdrawal-induced depression using… read more here.
Keywords: ethanol withdrawal; withdrawal induced; withdrawal; rat ... See more keywords
Protective influences of N-acetylcysteine against alcohol abstinence-induced depression by regulating biochemical and GRIN2A, GRIN2B gene expression of NMDA receptor signaling pathway in rats
Sign Up to like & getrecommendations! Published in 2018 at "Neurochemistry International"
DOI: 10.1016/j.neuint.2018.04.011
Abstract: ABSTRACT Evidences have indicated a high degree of comorbidity of alcoholism and depression. N‐acetylcysteine (NAC) has shown its clinical efficiency in the treatment of several psychiatric disorders and is identified as a multi‐target acting drug.… read more here.
Keywords: alcohol abstinence; abstinence; abstinence induced; alcohol ... See more keywords
Apelin-13 Upregulates BDNF Against Chronic Stress-induced Depression-like Phenotypes by Ameliorating HPA Axis and Hippocampal Glucocorticoid Receptor Dysfunctions
Sign Up to like & getrecommendations! Published in 2018 at "Neuroscience"
DOI: 10.1016/j.neuroscience.2018.08.018
Abstract: Localization of apelin and its receptor APJ in limbic structures such as the hippocampus suggests potential involvement of apelin/APJ signaling in stress-related emotional responses. We have recently reported that apelin-13 exerts antidepressant-like actions in acute… read more here.
Keywords: like phenotypes; apelin; stress; receptor ... See more keywords
microRNA and mRNA profiles in ventral tegmental area relevant to stress-induced depression and resilience
Sign Up to like & getrecommendations! Published in 2018 at "Progress in Neuro-Psychopharmacology and Biological Psychiatry"
DOI: 10.1016/j.pnpbp.2018.05.023
Abstract: &NA; Chronic stress with lack of reward presumably may impair brain reward circuit, leading to major depressive disorder (MDD). Most individuals experiencing chronic stress do not suffer from MDD, i.e., resilience, implying the presence of… read more here.
Keywords: depression; resilience; ventral tegmental; stress induced ... See more keywords
Ketamine induces rapid and sustained antidepressant-like effects in chronic pain induced depression: Role of MAPK signaling pathway
Sign Up to like & getrecommendations! Published in 2020 at "Progress in Neuro-Psychopharmacology and Biological Psychiatry"
DOI: 10.1016/j.pnpbp.2020.109898
Abstract: Chronic pain produces psychologic distress, which often leads to mood disorders such as depression. Co-existing chronic pain and depression pose a serious socio-economic burden and result in disability affecting millions individuals, which urges the development… read more here.
Keywords: pain induced; ketamine; chronic pain; induced depression ... See more keywords
Cyanidin Chloride Improves LPS-Induced Depression-Like Behavior in Mice by Ameliorating Hippocampal Inflammation and Excitotoxicity.
Sign Up to like & getrecommendations! Published in 2022 at "ACS chemical neuroscience"
DOI: 10.1021/acschemneuro.2c00087
Abstract: Depression is a global disease that places a significant burden on human health. Neuroinflammation and disturbance of glutamate metabolism in brain regions, such as the hippocampus, play vital roles in the development of depression. Previous… read more here.
Keywords: cycl; inflammation; cyanidin chloride; depression ... See more keywords
Stress-induced depression
Sign Up to like & getrecommendations! Published in 2017 at "Nature Immunology"
DOI: 10.1038/s41590-017-0038-2
Abstract: Exposure to chronic emotional stress is linked to the activation of innate immune responses and depression. In Nature Neuroscience, Menard et al. show that stressed mice develop increased permeability of the blood–brain barrier in the… read more here.
Keywords: depression; stress induced; stress; brain ... See more keywords
The effect of vitamin B6 on dexamethasone-induced depression in mice model of despair
Sign Up to like & getrecommendations! Published in 2018 at "Nutritional Neuroscience"
DOI: 10.1080/1028415x.2018.1442184
Abstract: Objective: Glucocorticoid receptors (GRs) have an important role in mediating the effects of glucocorticoids (GCs) on brain plasticity and mood. GC drugs and elevated cortisol level can cause psychiatric disorders including depression. The B-vitamins have… read more here.
Keywords: depression; depression mice; dex; effect vitamin ... See more keywords