Extracellular Vesicles from Gram-positive and Gram-negative Probiotics Remediate Stress-Induced Depressive Behavior in Mice.
Sign Up to like & getrecommendations! Published in 2022 at "Molecular neurobiology"
DOI: 10.1007/s12035-021-02655-9
Abstract: Chronic stress causes maladaptive changes in the brain that lead to depressive behavior. In the present study, we investigate whether chronic stress alters gut microbiota compositions that are related to stress-induced maladaptive changes in the… read more here.
Keywords: stress; gram positive; stress induced; induced depressive ... See more keywords
Proanthocyanidin prevents lipopolysaccharide-induced depressive-like behavior in mice via neuroinflammatory pathway
Sign Up to like & getrecommendations! Published in 2017 at "Brain Research Bulletin"
DOI: 10.1016/j.brainresbull.2017.09.010
Abstract: Recent studies have demonstrated neuroinflammation and increased cytokine levels are associated with depression. Aware of the efficacy the potential anti-inflammatory and antioxidative activity of proanthocyanidin, the present study was designed to investigate the effects of… read more here.
Keywords: induced depressive; lps induced; proanthocyanidin; like behavior ... See more keywords
Hippocampal overexpression of chordin protects against the chronic social defeat stress-induced depressive-like effects in mice
Sign Up to like & getrecommendations! Published in 2020 at "Brain Research Bulletin"
DOI: 10.1016/j.brainresbull.2020.02.010
Abstract: Depression is a serious and worldwide neuropsychiatric disesase, and developing novel antidepressant targets beyond the monoaminergic systems is now popular and necessary. Bone morphogenetic protein (BMP) signals modulate numerous developmental, physiological, and homeostatic processes. The… read more here.
Keywords: induced depressive; chordin; social defeat; defeat stress ... See more keywords
Ketamine, but not guanosine, as a prophylactic agent against corticosterone-induced depressive-like behavior: Possible role of long-lasting pro-synaptogenic signaling pathway
Sign Up to like & getrecommendations! Published in 2020 at "Experimental Neurology"
DOI: 10.1016/j.expneurol.2020.113459
Abstract: Ketamine has been reported to exert a prophylactic effect against stress-induced depressive-like behavior by modulating the guanosine-based purinergic system. However, the molecular pathways underlying its prophylactic effect and whether guanosine also elicits a similar effect… read more here.
Keywords: induced depressive; like behavior; effect; depressive like ... See more keywords
RGFP966 is protective against lipopolysaccharide-induced depressive-like behaviors in mice by inhibiting neuroinflammation and microglial activation.
Sign Up to like & getrecommendations! Published in 2021 at "International immunopharmacology"
DOI: 10.1016/j.intimp.2021.108259
Abstract: Depression is a prevalent mental disorder. However, its pathophysiological mechanism has still remained elusive, and a limited number of effective treatments have been presented. Recent studies have shown that neuroinflammation and microglial activation are involved… read more here.
Keywords: induced depressive; rgfp966; behaviors mice; like behaviors ... See more keywords
Clostridium butyricum Attenuates Chronic Unpredictable Mild Stress-Induced Depressive-Like Behavior in Mice via the Gut-Brain Axis.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.8b02462
Abstract: Abnormal gut microbiome has been associated with depression. The mechanism of probiotics against depression remains unclear. This study aimed to determine whether Clostridium butyricum (Cb) could attenuate chronic unpredictable mild stress-induced depressive-like behavior and its… read more here.
Keywords: induced depressive; chronic unpredictable; like behavior; depressive like ... See more keywords
Dynorphin promotes stress‐induced depressive behaviors by inhibiting ventral pallidal neurons in rats
Sign Up to like & getrecommendations! Published in 2022 at "Acta Physiologica"
DOI: 10.1111/apha.13882
Abstract: Endogenous dynorphin signaling via kappa opioid receptors (KORs) plays a key role in producing the depressive and aversive consequences of stress. We investigated the behavioral effects of the dynorphin/KOR system in the ventral pallidum (VP)… read more here.
Keywords: promotes stress; depressive behaviors; induced depressive; stress induced ... See more keywords
Characterized profiles of gut microbiota in morphine abstinence-induced depressive-like behavior
Sign Up to like & getrecommendations! Published in 2022 at "Neuroscience Letters"
DOI: 10.2139/ssrn.4078596
Abstract: Morphine is the most widely used analgesic for pain management worldwide. Abstinence of morphine could lead to neuropsychiatric symptoms, including depression. Gut microbiota is believed to contribute to the development of depression. However, the characteristics… read more here.
Keywords: morphine abstinence; induced depressive; gut microbiota; abstinence ... See more keywords
Roxadustat (FG-4592) abated lipopolysaccharides-induced depressive-like symptoms via PI3K signaling
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Molecular Neuroscience"
DOI: 10.3389/fnmol.2023.1048985
Abstract: Background Despite its role in inflammation and the redox system under hypoxia, the effects and molecular mechanisms of hypoxia-inducible factor (HIF) in neuroinflammation-associated depression are poorly explored. Furthermore, Prolyl hydroxylase domain-containing proteins (PHDs) regulate HIF-1;… read more here.
Keywords: induced depressive; via pi3k; depression; pi3k signaling ... See more keywords