ATP antagonizes the crowding-induced destabilization of the human eye-lens protein γS-crystallin.
Sign Up to like & getrecommendations! Published in 2020 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2020.04.014
Abstract: In lens, αβγ-crystallins accounting for ∼90% of ocular proteins with concentrations >400 mg/ml need to remain soluble for the whole life-span and their aggregation can lead to cataract. Mysteriously, despite being a metabolically-quiescent organ, lens maintains… read more here.
Keywords: aggregation; crowding induced; crystallin; eye ... See more keywords
Concept article: Antidepressant‐induced destabilization in bipolar illness mediated by serotonin 3 receptor (5HT3)
Sign Up to like & getrecommendations! Published in 2024 at "Bipolar Disorders"
DOI: 10.1111/bdi.13494
Abstract: Antidepressants used by patients with bipolar disorder have been associated with destabilization with an increase in mania, depression, and cycling. The most commonly proposed mechanism, that antidepressants ‘overshoot’ their antidepressant effect to create a manic… read more here.
Keywords: bipolar; induced destabilization; article antidepressant; destabilization ... See more keywords