Identification of Immune Checkpoint Inhibitor-Induced Diabetes.
Sign Up to like & getrecommendations! Published in 2024 at "JAMA oncology"
DOI: 10.1001/jamaoncol.2024.3104
Abstract: Importance Immune checkpoint inhibitors (ICIs) have revolutionized cancer care; however, accompanying immune-related adverse events (irAEs) confer substantial morbidity and occasional mortality. Life-threatening irAEs may require permanent cessation of ICI, even in patients with positive tumor… read more here.
Keywords: induced diabetes; ici induced; iraes; immune checkpoint ... See more keywords
Congenic mapping and candidate gene analysis for streptozotocin-induced diabetes susceptibility locus on mouse chromosome 11
Sign Up to like & getrecommendations! Published in 2018 at "Mammalian Genome"
DOI: 10.1007/s00335-018-9742-y
Abstract: Streptozotocin (STZ) has been widely used to induce diabetes in rodents. Strain-dependent variation in susceptibility to STZ has been reported; however, the gene(s) responsible for STZ susceptibility has not been identified. Here, we utilized the… read more here.
Keywords: susceptibility; stz; diabetes susceptibility; induced diabetes ... See more keywords
Calcium dobesilate prevents the oxidative stress and inflammation induced by diabetes in the retina of db/db mice.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of diabetes and its complications"
DOI: 10.1016/j.jdiacomp.2017.07.009
Abstract: AIM Calcium dobesilate (CaD) is beneficial in early stages of diabetic retinopathy (DR), but its mechanisms of action remains to be elucidated. The aim was to investigate the effect of CaD on proinflammatory cytokines and… read more here.
Keywords: calcium dobesilate; cad; retina mice; induced diabetes ... See more keywords
Exploring dose–response variability and relative severity assessment in STZ-induced diabetes male NSG mice
Sign Up to like & getrecommendations! Published in 2024 at "Scientific Reports"
DOI: 10.1038/s41598-024-67490-z
Abstract: NSG mice are among the most immunodeficient mouse model being used in various scientific branches. In diabetelogical research diabetic NSG mice are an important asset as a xenotransplantation model for human pancreatic islets or pluripotent… read more here.
Keywords: mice; relative severity; nsg mice; male nsg ... See more keywords
Divergent outcomes of gut microbiota alteration upon use of spectrum antibiotics in high sugar diet-induced diabetes in rats
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DOI: 10.1039/c8ra03774d
Abstract: Background: A sugar rich diet induces inflammation and insulin resistance (IR) mainly through gut microbiota alteration. Gut dysbiosis increases lipopolysaccharide (LPS) and reduces propionate and butyrate levels to impair the insulin signalling cascades by different… read more here.
Keywords: microbiota alteration; diet induced; spectrum; induced diabetes ... See more keywords
The evaluation of early stage oxidative status in streptozotocin induced diabetes in rats.
Sign Up to like & getrecommendations! Published in 2020 at "Archives of physiology and biochemistry"
DOI: 10.1080/13813455.2020.1776736
Abstract: Early-stage diabetes can be defined as the stages before absolute insulin deficiency in patients. In this study, the early stage oxidative effect of streptozotocin(STZ) induced diabetes mellitus was evaluated. 28 male adult Sprague-Dawley rats were… read more here.
Keywords: evaluation early; induced diabetes; streptozotocin; stage oxidative ... See more keywords
Immunological markers as predictors of developing steroid-induced diabetes mellitus in pemphigus vulgaris patients
Sign Up to like & getrecommendations! Published in 2018 at "Medicine"
DOI: 10.1097/md.0000000000010463
Abstract: Abstract The aim of this study was to evaluate the clinical importance of autoantibodies in pemphigus vulgaris patients who developed steroid-induced diabetes mellitus (SID) because of the glucocorticoid therapy of pemphigus. A total of 137… read more here.
Keywords: pemphigus vulgaris; steroid induced; vulgaris patients; induced diabetes ... See more keywords
Oral treatment of glucocorticoid‐induced diabetes mellitus: A systematic review
Sign Up to like & getrecommendations! Published in 2020 at "International Journal of Clinical Practice"
DOI: 10.1111/ijcp.13529
Abstract: Glucocorticoid-induced diabetes mellitus (GIDM) is a well-known and common metabolic side effect of glucocorticoid (GC) treatment. The risk of developing GIDM in non-diabetic patients who receive systemic GCs, was evaluated in a metanalysis and found… read more here.
Keywords: oral treatment; glucocorticoid induced; treatment; glucocorticoid ... See more keywords
Periodontitis exacerbates endothelial dysfunctions partly via endothelial-mesenchymal transition in streptozotocin-induced diabetes rats.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of periodontal research"
DOI: 10.1111/jre.12994
Abstract: OBJECTIVES Periodontal infections are related to the expansion of diabetes cardiovascular problems. However, the pathological process and probable mechanism remain unexplained. This study investigated the impact of periodontitis on streptozotocin (STZ)-induced diabetes rats' carotid artery.… read more here.
Keywords: mesenchymal transition; diabetes rats; induced diabetes; endothelial mesenchymal ... See more keywords
Immune checkpoint inhibitor-induced diabetes mellitus with nivolumab
Sign Up to like & getrecommendations! Published in 2023 at "BMJ Case Reports"
DOI: 10.1136/bcr-2022-253696
Abstract: Immune checkpoint inhibitors (ICIs) have been increasingly used in the treatment of various advanced cancers; however, therapy can be complicated by immune-related adverse events (irAEs). We present the case of a man in his 40s,… read more here.
Keywords: checkpoint inhibitor; immune checkpoint; induced diabetes; ici ... See more keywords
Antioxidant Effect of Jatropha dioica Extract on Immunoreactivity of Claudin 2 in the Kidney of Rats with Induced Diabetes
Sign Up to like & getrecommendations! Published in 2023 at "Natural Product Communications"
DOI: 10.1177/1934578x231157183
Abstract: Introduction Diabetes is related to different complications, such as nephropathy. In kidneys, the tight junctions (TJ) regulate the paracellular transport of solutes and water. The claudins are the most significant component in the TJ and… read more here.
Keywords: antioxidant effect; kidney; effect jatropha; induced diabetes ... See more keywords