Small Molecule‐Induced Differentiation As a Potential Therapy for Liver Cancer
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Science"
DOI: 10.1002/advs.202103619
Abstract: Despite the efficacy demonstrated by immunotherapy recently, liver cancer still remains one of the deadliest cancers, mainly due to heterogeneity of this disease. Continuous exploration of new therapeutics is therefore necessary. Chemical‐induced cell differentiation can… read more here.
Keywords: small molecule; liver cancer; cancer; induced differentiation ... See more keywords
Proteomic Profiling of HL-60 Cells during ATRA-Induced Differentiation
Sign Up to like & getrecommendations! Published in 2018 at "Bulletin of Experimental Biology and Medicine"
DOI: 10.1007/s10517-018-4210-y
Abstract: Acute promyelocytic leukemia, a form of acute myeloid leukemia, is characterized by cell differentiation arrest at the promyelocyte stage. Current therapeutic options include administration of all trans-retinoic acid (ATRA), but this treatment produces many side… read more here.
Keywords: induced differentiation; atra induced; proteomic profiling; differentiation ... See more keywords
Induced differentiation and molecular characterization of monocyte-derived multipotential cells (MOMCs) generated from commonly discarded leukapheresis filters
Sign Up to like & getrecommendations! Published in 2019 at "Cytotherapy"
DOI: 10.1016/j.jcyt.2019.03.480
Abstract: Background & Aim Μonocyte-derived multipotential cells (MOMCs), easily isolated from the peripheral blood, include progenitors capable of differentiating into endothelial lineages in a specific permissive environment and thus represent an autologous transplantable cell source for… read more here.
Keywords: differentiation; derived multipotential; induced differentiation; multipotential cells ... See more keywords
Sodium Tanshinone IIA Sulfonate Prevents Angiotensin II-Induced Differentiation of Human Atrial Fibroblasts into Myofibroblasts
Sign Up to like & getrecommendations! Published in 2018 at "Oxidative Medicine and Cellular Longevity"
DOI: 10.1155/2018/6712585
Abstract: Differentiation of atrial fibroblasts into myofibroblasts plays a critical role in atrial fibrosis. Sodium tanshinone IIA sulfonate (DS-201), a water-soluble derivative of tanshinone IIA, has been shown to have potent antifibrotic properties. However, the protective… read more here.
Keywords: induced differentiation; atrial fibroblasts; tanshinone iia; fibroblasts myofibroblasts ... See more keywords
Evidence of Decreased Activity in Intermediate-Conductance Calcium-Activated Potassium Channels During Retinoic Acid–Induced Differentiation in Motor Neuron–Like NSC-34 Cells
Sign Up to like & getrecommendations! Published in 2018 at "Cellular Physiology and Biochemistry"
DOI: 10.1159/000492653
Abstract: Background/Aims: Intermediate-conductance Ca2+-activated K+ (IKCa; KCa3.1 or KCNN4) channels affect the behaviors of central neurons including motor neurons. The mechanism through which neuronal differentiation is related to the activity of these channels remains largely unclear.… read more here.
Keywords: induced differentiation; activity; nsc cells; ikca channels ... See more keywords
Role for Fgr and Numb in retinoic acid-induced differentiation and G0 arrest of non-APL AML cells
Sign Up to like & getrecommendations! Published in 2021 at "Oncotarget"
DOI: 10.18632/oncotarget.27969
Abstract: Retinoic acid (RA) is a fundamental regulator of cell cycle and cell differentiation. Using a leukemic patient-derived in vitro model of a non-APL AML, we previously found that RA evokes activation of a macromolecular signaling… read more here.
Keywords: induced differentiation; differentiation arrest; arrest; differentiation ... See more keywords
Somatostatin-Mediated Regulation of Retinoic Acid-Induced Differentiation of SH-SY5Y Cells: Neurotransmitters Phenotype Characterization
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DOI: 10.3390/biomedicines10020337
Abstract: During brain development, neurite formation plays a critical role in neuronal communication and cognitive function. In the present study, we compared developmental changes in the expression of crucial markers that govern the functional activity of… read more here.
Keywords: sy5y cells; induced differentiation; acid induced; acid ... See more keywords