Genistein‐induced DNA damage is repaired by nonhomologous end joining and homologous recombination in TK6 cells
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.27082
Abstract: Genistein (GES), a phytoestrogen, has potential chemopreventive and chemotherapeutic effects on cancer. The anticancer mechanism of GES may be related with topoisomerase II associated DNA double‐strand breaks (DSBs). However, the precise molecular mechanism remains elusive.… read more here.
Keywords: end joining; dna damage; tk6; induced dna ... See more keywords
Nuclear Deformation Causes DNA Damage by Increasing Replication Stress
Sign Up to like & getrecommendations! Published in 2021 at "Current Biology"
DOI: 10.1016/j.cub.2020.11.037
Abstract: Cancer metastasis, i.e., the spreading of tumor cells from the primary tumor to distant organs, is responsible for the vast majority of cancer deaths. In the process, cancer cells migrate through narrow interstitial spaces substantially… read more here.
Keywords: dna damage; deformation; induced dna; damage ... See more keywords
Resolvin D1 attenuates acid-induced DNA damage in esophageal epithelial cells and rat models of acid reflux.
Sign Up to like & getrecommendations! Published in 2021 at "European journal of pharmacology"
DOI: 10.1016/j.ejphar.2021.174571
Abstract: The role of resolvin D1 (RvD1) in gastroesophageal reflux disease (GERD) remains largely unknown. Here, we investigated the potential role of RvD1 in acid-induced DNA damage in esophageal epithelial cells, patients with refractory GERD and… read more here.
Keywords: dna damage; epithelial cells; induced dna; damage ... See more keywords
Genotoxicity assessment of saline extract from Pilosocereus gounellei (Cactaceae) and its chemopreventive effect against cyclophosphamide-induced DNA damage
Sign Up to like & getrecommendations! Published in 2020 at "Heliyon"
DOI: 10.1016/j.heliyon.2020.e03811
Abstract: Pilosocereus gounellei (Cactaceae) is used to treat wounds and inflammation. In this study, we evaluated whether the saline extract from its stem would have genotoxic or anti-genotoxic effects. In the genotoxicity evaluation, mice received the… read more here.
Keywords: dna damage; pilosocereus gounellei; genotoxicity; induced dna ... See more keywords
Evidence for the role of BmNPV Bm65 protein in the repair of ultraviolet-induced DNA damage.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of invertebrate pathology"
DOI: 10.1016/j.jip.2017.08.004
Abstract: It is unclear how, or to what extent, baculovirus DNA that has been damaged by ultraviolet (UV) light is repaired during infection and replication. In our previous study, expression of Bombyx mori nucleopolyhedrovirus (BmNPV) ORF… read more here.
Keywords: dna damage; bm65; bmnpv; induced dna ... See more keywords
Crowding-Induced DNA Translocation Through a Protein Nanopore.
Sign Up to like & getrecommendations! Published in 2020 at "Analytical chemistry"
DOI: 10.1021/acs.analchem.9b05249
Abstract: Crowded cellular environment is highly associated with many significant biological processes. However, the effect of molecular crowding on the translocation behavior of DNA through a pore has not been explored. Here, we use nanopore single-molecule… read more here.
Keywords: dna translocation; dna; crowding induced; induced dna ... See more keywords
Escin-induced DNA damage promotes escin-induced apoptosis in human colorectal cancer cells via p62 regulation of the ATM/γH2AX pathway
Sign Up to like & getrecommendations! Published in 2018 at "Acta Pharmacologica Sinica"
DOI: 10.1038/aps.2017.192
Abstract: Escin, a triterpene saponin isolated from horse chestnut seed, has been used to treat encephaledema, tissue swelling and chronic venous insufficiency. Recent studies show that escin induces cell cycle arrest, tumor proliferation inhibition and tumor… read more here.
Keywords: induced dna; dna damage; escin induced; apoptosis ... See more keywords
p38-MK2 signaling axis regulates RNA metabolism after UV-light-induced DNA damage
Sign Up to like & getrecommendations! Published in 2018 at "Nature Communications"
DOI: 10.1038/s41467-018-03417-3
Abstract: Ultraviolet (UV) light radiation induces the formation of bulky photoproducts in the DNA that globally affect transcription and splicing. However, the signaling pathways and mechanisms that link UV-light-induced DNA damage to changes in RNA metabolism… read more here.
Keywords: dna damage; light induced; p38 mk2; induced dna ... See more keywords
The melanocortin signaling cAMP axis accelerates repair and reduces mutagenesis of platinum-induced DNA damage
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-12056-5
Abstract: Using primary melanocytes and HEK293 cells, we found that cAMP signaling accelerates repair of bi- and mono-functional platinum-induced DNA damage. Elevating cAMP signaling either by the agonistic MC1R ligand melanocyte stimulating hormone (MSH) or by… read more here.
Keywords: dna damage; platinum; camp; induced dna ... See more keywords
Amplified impedimetric aptasensor combining target-induced DNA hydrogel formation with pH-stimulated signal amplification for the heparanase assay.
Sign Up to like & getrecommendations! Published in 2017 at "Nanoscale"
DOI: 10.1039/c6nr08353f
Abstract: Herein, a novel electrochemical impedimetric biosensor for the heparanase (HPA) assay was developed based on target protein-induced DNA hydrogel formation, followed by pH-stimulation of the hydrogel density to increase the signal amplification. The method involved… read more here.
Keywords: hydrogel; dna; formation; induced dna ... See more keywords
N-Doped graphene quantum dots (N-GQDs) as fluorescent probes for detection of UV induced DNA damage
Sign Up to like & getrecommendations! Published in 2022 at "RSC Advances"
DOI: 10.1039/d2ra04462e
Abstract: UV induced DNA damage can lead to the development of skin cancer, skin aging and cell death. In this study, we fabricated a fluorescence-based biosensor that can be applied to the detection of DNA damage… read more here.
Keywords: damage; graphene quantum; dna damage; induced dna ... See more keywords