Pallidal versus subthalamic nucleus deep brain stimulation for levodopa‐induced dyskinesia
Sign Up to like & getrecommendations! Published in 2019 at "Annals of Clinical and Translational Neurology"
DOI: 10.1002/acn3.50961
Abstract: To compare the efficacy of subthalamic nucleus (STN) and globus pallidus internus (GPi) deep brain stimulation (DBS) on reducing levodopa‐induced dyskinesia (LID) in Parkinson’s disease, and to explore the potential underlying mechanisms. read more here.
Keywords: deep brain; levodopa induced; subthalamic nucleus; induced dyskinesia ... See more keywords
White matter hyperintensities and risk of levodopa‐induced dyskinesia in Parkinson’s disease
Sign Up to like & getrecommendations! Published in 2020 at "Annals of Clinical and Translational Neurology"
DOI: 10.1002/acn3.50991
Abstract: To investigate whether the burden of white matter hyperintensities (WMHs) is associated with the risk of developing levodopa‐induced dyskinesia (LID) in Parkinson’s disease (PD). read more here.
Keywords: levodopa induced; parkinson disease; induced dyskinesia; matter hyperintensities ... See more keywords
Levodopa‐induced dyskinesia in Parkinson disease: Current and evolving concepts
Sign Up to like & getrecommendations! Published in 2018 at "Annals of Neurology"
DOI: 10.1002/ana.25364
Abstract: Levodopa‐induced dyskinesia is a common complication in Parkinson disease. Pathogenic mechanisms include phasic stimulation of dopamine receptors, nonphysiological levodopa‐to‐dopamine conversion in serotonergic neurons, hyperactivity of corticostriatal glutamatergic transmission, and overstimulation of nicotinic acetylcholine receptors on… read more here.
Keywords: dyskinesia parkinson; levodopa induced; disease; parkinson disease ... See more keywords
Phenomenology and Management of Subthalamic Stimulation‐Induced Dyskinesia in Patients With Isolated Dystonia
Sign Up to like & getrecommendations! Published in 2020 at "Movement Disorders Clinical Practice"
DOI: 10.1002/mdc3.12946
Abstract: The pallidum has been the preferred DBS target for dystonia, but recent studies have shown equal or greater improvement in patients implanted in the STN.1 Transient stimulation‐induced dyskinesia (SID) is frequently observed when stimulating this… read more here.
Keywords: management subthalamic; stimulation induced; subthalamic stimulation; phenomenology management ... See more keywords
Randomized, placebo‐controlled trial of ADS‐5102 (amantadine) extended‐release capsules for levodopa‐induced dyskinesia in Parkinson's disease (EASE LID 3)
Sign Up to like & getrecommendations! Published in 2017 at "Movement Disorders"
DOI: 10.1002/mds.27131
Abstract: The treatment of levodopa‐induced dyskinesia in Parkinson's disease (PD) is an unmet need with no approved drug therapy. read more here.
Keywords: dyskinesia parkinson; induced dyskinesia; levodopa induced; parkinson disease ... See more keywords
Immunomodulatory drugs alleviate l‐dopa‐induced dyskinesia in a rat model of Parkinson's disease
Sign Up to like & getrecommendations! Published in 2019 at "Movement Disorders"
DOI: 10.1002/mds.27799
Abstract: Thalidomide and closely related analogues are used clinically for their immunomodulatory and antiangiogenic properties mediated by the inhibition of the proinflammatory cytokine tumor necrosis factor α. Neuroinflammation and angiogenesis contribute to classical neuronal mechanisms underpinning… read more here.
Keywords: parkinson; dopa induced; induced dyskinesia; parkinson disease ... See more keywords
Serotonergic targets for the treatment of l-DOPA-induced dyskinesia
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Neural Transmission"
DOI: 10.1007/s00702-017-1837-1
Abstract: Dopamine (DA) replacement therapy with l-3,4-dihydroxyphenylalanine (l-DOPA) continues to be the gold-standard treatment for Parkinson’s disease (PD). Despite clear symptomatic benefit, long-term l-DOPA use often results in the development of l-DOPA-induced dyskinesia (LID), significantly reducing… read more here.
Keywords: targets treatment; treatment; serotonergic targets; dopa ... See more keywords
Neuroinflammation in l-DOPA-induced dyskinesia: beyond the immune function
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Neural Transmission"
DOI: 10.1007/s00702-018-1874-4
Abstract: Neuroinflammation is a main component of Parkinson’s disease (PD) neuropathology, where unremitting reactive microglia and microglia-secreted soluble molecules such as cytokines, contribute to the neurodegenerative process as part of an aberrant immune reaction. Besides, pro-inflammatory… read more here.
Keywords: neuroinflammation; neuroinflammation dopa; dopa induced; function ... See more keywords
Levodopa-induced dyskinesia: clinical features, incidence, and risk factors
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Neural Transmission"
DOI: 10.1007/s00702-018-1900-6
Abstract: Symptoms of Parkinson’s disease have been controlled with levodopa for many years; however, motor complications consisting of wearing off of medication effect and dyskinesias tend to occur within a few years of starting levodopa. Motor… read more here.
Keywords: disease; risk factors; levodopa induced; dyskinesia ... See more keywords
Effects of histone acetyltransferase inhibitors on l-DOPA-induced dyskinesia in a murine model of Parkinson’s disease
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Neural Transmission"
DOI: 10.1007/s00702-018-1902-4
Abstract: Histone acetylation is a key regulatory factor for gene expression in cells. Modulation of histone acetylation by targeting of histone acetyltransferases (HATs) effectively alters many gene expression profiles and synaptic plasticity in the brain. However,… read more here.
Keywords: dopa induced; induced dyskinesia; parkinson disease;
A Web Resource for Levodopa-Induced Dyskinesia Genetics in Parkinson’s Disease
Sign Up to like & getrecommendations! Published in 2017 at "Neuroinformatics"
DOI: 10.1007/s12021-017-9327-z
Abstract: Levodopa-induced dyskinesia (LID) is a side effect of Parkinson’s disease (PD) therapy. The time span from levodopa therapy initiation to the appearance of LID is variable between patients and several publications have investigated a potential… read more here.
Keywords: levodopa; genetics; levodopa induced; web resource ... See more keywords