The striatal cholinergic system in l-dopa-induced dyskinesias
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DOI: 10.1007/s00702-018-1845-9
Abstract: Cholinergic signaling plays a key role in regulating striatal function. The principal source of acetylcholine in the striatum is the cholinergic interneurons which, although low in number, densely arborize to modulate striatal neurotransmission. This modulation… read more here.
Keywords: induced dyskinesias; dopa induced; cholinergic system; cholinergic ... See more keywords
Axial levodopa-induced dyskinesias and neuronal activity in the dorsal striatum
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DOI: 10.1016/j.neuroscience.2016.11.046
Abstract: Levodopa-induced dyskinesias are abnormal involuntary movements that limit the effectiveness of treatments for Parkinson's disease. Although dyskinesias involve the striatum, it is unclear how striatal neurons are involved in dyskinetic movements. Here we record from… read more here.
Keywords: induced dyskinesias; neuronal activity; axial dyskinesias; levodopa induced ... See more keywords
Technological prospection: patents mapping involving compounds for the treatment of L-DOPA-induced dyskinesias
Sign Up to like & getrecommendations! Published in 2019 at "Expert Opinion on Therapeutic Patents"
DOI: 10.1080/13543776.2019.1690453
Abstract: ABSTRACT Introduction: Parkinson’s disease (PD), is a disorder debilitant characterized by the reduction of nigrostriatal dopaminergic neurons within the midbrain, specifically in the substantia nigra pars compacta, which results for the dopamine (DA) depletion in… read more here.
Keywords: induced dyskinesias; treatment; technological prospection; dopa induced ... See more keywords
7-Nitroindazole reduces L-DOPA-induced dyskinesias in non-human Parkinsonian primate
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DOI: 10.1098/rsob.220370
Abstract: Nitric oxide (NO) plays a pivotal role in integrating dopamine transmission in the basal ganglia and has been implicated in the pathogenesis of Parkinson disease (PD). The objective of this study was to ascertain whether… read more here.
Keywords: primate; dopa induced; induced dyskinesias; treatment ... See more keywords
Intrastriatal Memantine Infusion Dampens Levodopa-Induced Dyskinesia and Motor Deficits in a Mouse Model of Hemiparkinsonism
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Neurology"
DOI: 10.3389/fneur.2019.01258
Abstract: Although the administration of dopamine precursor levodopa remains as the mainstay for the treatment of Parkinson's disease, long-term exposure to levodopa often causes a disabling complication, referred to as levodopa-induced dyskinesias. Therefore, the development of… read more here.
Keywords: infusion; induced dyskinesias; levodopa induced; motor deficits ... See more keywords