rBmTI-6 attenuates pathophysiological and inflammatory parameters of induced emphysema in mice.
Sign Up to like & getrecommendations! Published in 2018 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2018.01.066
Abstract: Protease/anti-protease imbalance is the main pathogenic mechanism of emphysema and protease inhibitors have been recognized as potential molecules to treat the disease conditions. In this work the rBmTI-6 first domain (rBmTI-6-D1), a recombinant Kunitz-type serine… read more here.
Keywords: rbmti; emphysema mice; induced emphysema; mice ... See more keywords
AT‐RVD1 repairs mouse lung after cigarette smoke‐induced emphysema via downregulation of oxidative stress by NRF2/KEAP1 pathway
Sign Up to like & getrecommendations! Published in 2018 at "International Immunopharmacology"
DOI: 10.1016/j.intimp.2018.01.045
Abstract: &NA; Long‐term exposure to cigarette smoke (CS) results in alveolar parenchyma destruction due to chronic inflammatory response and the imbalance between oxidants and antioxidants, and proteases and antiproteases. Emphysema is the main symptom of chronic… read more here.
Keywords: keap1 pathway; cigarette smoke; induced emphysema; nrf2 keap1 ... See more keywords