Combination of antiseizure medications phenobarbital, ketamine and midazolam reduces soman-induced epileptogenesis and brain pathology in rats.
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DOI: 10.1002/epi4.12552
Abstract: OBJECTIVE Cholinergic-induced status epilepticus (SE) is associated with a loss of synaptic gamma-aminobutyric acid A receptors (GABAA R) and an increase in N-methyl-D-aspartate receptors (NMDAR) and amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors (AMPAR) that may contribute to pharmacoresistance… read more here.
Keywords: ketamine; midazolam; pathology; soman induced ... See more keywords