Atorvastatin attenuates paraquat poisoning‐induced epithelial‐mesenchymal transition via downregulating hypoxia‐inducible factor‐1 alpha
Sign Up to like & getrecommendations! Published in 2018 at "Life Sciences"
DOI: 10.1016/j.lfs.2018.10.026
Abstract: Aim: This study investigated the effects of atorvastatin (ATS) on the paraquat (PQ)‐induced epithelial‐mesenchymal transition (EMT) and the potential mechanism through hypoxia‐inducible factor‐1 alpha (HIF‐1&agr;). Main methods: Sprague–Dawley (SD) rats were randomly divided into a… read more here.
Keywords: mesenchymal transition; inducible factor; induced epithelial; epithelial mesenchymal ... See more keywords
Slit2 ameliorates renal inflammation and fibrosis after hypoxia‐and lipopolysaccharide‐induced epithelial cells injury in vitro
Sign Up to like & getrecommendations! Published in 2017 at "Experimental Cell Research"
DOI: 10.1016/j.yexcr.2017.02.001
Abstract: ABSTRACT Hypoxic acute kidney injury (AKI) is often incompletely repaired and leads to chronic kidney disease (CKD), which is characterized by tubulointerstitial inflammation and fibrosis. The Slit2 family of secreted glycoproteins is expressed in the… read more here.
Keywords: epithelial cells; fibrosis; induced epithelial; cells injury ... See more keywords
Stevioside inhibits lipopolysaccharide-induced epithelial-to-mesenchymal transition of NRK-52E cells by PPARγ activation
Sign Up to like & getrecommendations! Published in 2022 at "Immunopharmacology and Immunotoxicology"
DOI: 10.1080/08923973.2022.2039935
Abstract: Abstract Background Stevioside is a natural diterpenoid compound that possesses anti-inflammatory, immunomodulatory, anti-diabetic, anti-hypertensive, and renal protective effects, but its effect on lipopolysaccharide (LPS)-induced epithelial-to-mesenchymal transition (EMT) of renal tubular epithelial cells, an important immune… read more here.
Keywords: mesenchymal transition; nrk 52e; smad2; epithelial mesenchymal ... See more keywords
Oestrogen-induced epithelial-mesenchymal transition (EMT) in endometriosis: Aetiology of vaginal agenesis in Mayer-Rokitansky-Küster-Hauser (MRKH) syndrome
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Physiology"
DOI: 10.3389/fphys.2022.937988
Abstract: Endometriosis occurs when endometrial-like tissue forms and grows outside the uterus due to oestrogen-induced epithelial-mesenchymal transition in the female reproductive tract. Factors that suppress this event could become potential therapeutic agents against disease occurrence and… read more here.
Keywords: oestrogen induced; induced epithelial; epithelial mesenchymal; mesenchymal transition ... See more keywords
3H-1,2-Dithiole-3-Thione Protects Lens Epithelial Cells against Fructose-Induced Epithelial-Mesenchymal Transition via Activation of AMPK to Eliminate AKR1B1-Induced Oxidative Stress in Diabetes Mellitus
Sign Up to like & getrecommendations! Published in 2021 at "Antioxidants"
DOI: 10.3390/antiox10071086
Abstract: Studies demonstrated that the receptor of advanced glycation end products (RAGE) induced epithelial-mesenchymal transition (EMT) formation in the lens epithelial cells (LECs) of diabetic cataracts. This work investigated how 3H-1,2-dithiole-3-thione (D3T) reduces EMT formation in… read more here.
Keywords: mesenchymal transition; epithelial cells; lens epithelial; fructose induced ... See more keywords
Chemical Investigation of Diketopiperazines and N-Phenethylacetamide Isolated from Aquimarina sp. MC085 and Their Effect on TGF-β-Induced Epithelial–Mesenchymal Transition
Sign Up to like & getrecommendations! Published in 2021 at "Applied Sciences"
DOI: 10.3390/app11198866
Abstract: Chemical investigations of Aquimarina sp. MC085, which suppressed TGF-β-induced epithelial–mesenchymal transition (EMT) in A549 human lung cancer cells, led to the isolation of compounds 1–3. Structural characterization using spectroscopic data analyses in combination with Marfey’s… read more here.
Keywords: mesenchymal transition; aquimarina mc085; tgf; induced epithelial ... See more keywords
Hypoxia Differently Affects TGF-β2-Induced Epithelial Mesenchymal Transitions in the 2D and 3D Culture of the Human Retinal Pigment Epithelium Cells
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23105473
Abstract: The hypoxia associated with the transforming growth factor-β2 (TGF-β2)-induced epithelial mesenchymal transition (EMT) of human retinal pigment epithelium (HRPE) cells is well recognized as the essential underlying mechanism responsible for the development of proliferative retinal… read more here.
Keywords: tgf induced; hrpe; hrpe cells; epithelial mesenchymal ... See more keywords
Inhibitory Effects of 3-Cyclopropylmethoxy-4-(difluoromethoxy) Benzoic Acid on TGF-β1-Induced Epithelial–Mesenchymal Transformation of In Vitro and Bleomycin-Induced Pulmonary Fibrosis In Vivo
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24076172
Abstract: Idiopathic pulmonary fibrosis (IPF) is a progressive lung disease characterized by lung inflammation and excessive deposition of extracellular matrix components. Transforming growth factor-β1 (TGF-β1) induced epithelial–mesenchymal transformation of type 2 lung epithelial cells leads to… read more here.
Keywords: tgf induced; pulmonary fibrosis; induced epithelial; fibrosis ... See more keywords
Ursolic Acid Attenuates TGF-β1-Induced Epithelial-Mesenchymal Transition in NSCLC by Targeting Integrin αVβ5/MMPs Signaling.
Sign Up to like & getrecommendations! Published in 2019 at "Oncology research"
DOI: 10.3727/096504017x15051723858706
Abstract: Transforming growth factor-β1 (TGF-β1)-induced epithelial-mesenchymal transition (EMT) of non-small cell lung cancer (NSCLC) may contribute to tumor metastasis. TGF-β1-induced EMT in H1975 cells (a human NSCLC cell line) resulted in the adoption of mesenchymal responses… read more here.
Keywords: epithelial mesenchymal; tgf induced; ursolic acid; induced epithelial ... See more keywords
Autophagy regulates TGF-β2-induced epithelial-mesenchymal transition in human retinal pigment epithelium cells
Sign Up to like & getrecommendations! Published in 2018 at "Molecular Medicine Reports"
DOI: 10.3892/mmr.2017.8360
Abstract: Transforming growth factor (TGF)-β2-induced epithelial-mesenchymal transition (EMT) in human retinal pigment epithelium (RPE) cells has an important role in the pathophysiology of intraocular fibrotic disorders, which may cause vision impairment and blindness. Autophagy, an intracellular… read more here.
Keywords: induced epithelial; induced emt; tgf induced; rpe ... See more keywords