1,3‐Dichloro‐2‐propanol induced ferroptosis through Nrf2/ARE signaling pathway in hepatocytes
Sign Up to like & getrecommendations! Published in 2022 at "Environmental Toxicology"
DOI: 10.1002/tox.23615
Abstract: 1,3‐Dichloro‐2‐propanol (1,3‐DCP) is a representative chloropropane environmental contaminant with multiple toxicities. Ferroptosis is a novel iron‐dependent form of regulated cell death that is closely associated with the accumulation of lipid peroxides, Fe2+ and reactive oxygen… read more here.
Keywords: signaling pathway; nrf2 signaling; dichloro propanol; induced ferroptosis ... See more keywords
Se‐Methylselenocysteine Ameliorates DEHP‐Induced Ferroptosis in Testicular Sertoli Cells via the Nrf2/GPX4 Axis
Sign Up to like & getrecommendations! Published in 2024 at "Environmental Toxicology"
DOI: 10.1002/tox.24425
Abstract: Di (2‐ethylhexyl) phthalate (DEHP) is an important plasticizer in industrial production, and its toxic effects on testes are widely recognized. Se‐methylselenocysteine (SMC) is a major selenium compound found in selenium‐rich plants, which possesses unique biological… read more here.
Keywords: dehp induced; ameliorates dehp; induced ferroptosis; smc ... See more keywords
DHA inhibits proliferation and induces ferroptosis of leukemia cells through autophagy dependent degradation of ferritin
Sign Up to like & getrecommendations! Published in 2019 at "Free Radical Biology and Medicine"
DOI: 10.1016/j.freeradbiomed.2018.12.011
Abstract: ABSTRACT Dihydroartemisinin (DHA) has been shown to be capable of inhibiting cancer growth, whereas it remains largely elusive that the underlying molecular mechanism of DHA induced acute myeloid leukemia (AML) cell death. In the present… read more here.
Keywords: dha induced; ferroptosis; dha; iron ... See more keywords
Resveratrol protected acrolein-induced ferroptosis and insulin secretion dysfunction via ER-stress- related PERK pathway in MIN6 cells.
Sign Up to like & getrecommendations! Published in 2021 at "Toxicology"
DOI: 10.1016/j.tox.2021.153048
Abstract: Acrolein is a typical food and environmental pollutant and a risk factor for diabetes. The primary pathogenesis of diabetes is insulin deficiency and resistance. Ferroptosis is an iron-dependent cell death type, accompanying by lipid peroxide… read more here.
Keywords: min6 cells; insulin secretion; ferroptosis; stress ... See more keywords
Chlorobenzoquinones Aggravate RSL3-Induced Ferroptosis in ROS-Dependent Manner.
Sign Up to like & getrecommendations! Published in 2024 at "Chemical research in toxicology"
DOI: 10.1021/acs.chemrestox.4c00100
Abstract: Chlorobenzoquinones (CBQs) are a class of emerging water disinfection byproducts that pose significant risks to public health. In this study, we found that three CBQs (tetrachloro-1,4-benzoquinone, 2,5-dichloro-1,4-benzoquinone, and 2-chloro-1,4-benzoquinone) can significantly aggravate cell death caused… read more here.
Keywords: rsl3; cbqs; chlorobenzoquinones aggravate; rsl3 induced ... See more keywords
Silencing of lncRNA MALAT1 facilitates erastin-induced ferroptosis in endometriosis through miR-145-5p/MUC1 signaling
Sign Up to like & getrecommendations! Published in 2022 at "Cell Death Discovery"
DOI: 10.1038/s41420-022-00975-w
Abstract: Endometriosis is a chronic disorder characterized by the implantation of endometrial glands and stroma outside the uterus. However, the pathogenesis of endometriosis is still unclear. To date, there is no fully effective treatment without trauma… read more here.
Keywords: muc1; mir 145; malat1; ferroptosis ... See more keywords
Resveratrol Protects BEAS-2B Cells against Erastin-Induced Ferroptosis through the Nrf2/Keap1 Pathway
Sign Up to like & getrecommendations! Published in 2022 at "Planta Medica"
DOI: 10.1055/a-1923-4399
Abstract: Abstract Ferroptosis is a newly discovered type of cell death that is different from other types of cell death morphologically and biologically. It is considered to play an important role in many pulmonary diseases. Currently,… read more here.
Keywords: resveratrol; induced ferroptosis; beas cells; cells erastin ... See more keywords
Platycodin D regulates high glucose-induced ferroptosis of HK-2 cells through glutathione peroxidase 4 (GPX4)
Sign Up to like & getrecommendations! Published in 2022 at "Bioengineered"
DOI: 10.1080/21655979.2022.2045834
Abstract: ABSTRACT Diabetic nephropathy (DN) is associated with inflammation. Platycodin D (PD) demonstrates anti-inflammatory activity. However, whether PD affects DN remains to be explored. Here, we aimed to discuss the role of PD in DN and… read more here.
Keywords: glucose induced; expression; gpx4 expression; induced ferroptosis ... See more keywords
Vitamin C Sensitizes Pancreatic Cancer Cells to Erastin-Induced Ferroptosis by Activating the AMPK/Nrf2/HMOX1 Pathway
Sign Up to like & getrecommendations! Published in 2022 at "Oxidative Medicine and Cellular Longevity"
DOI: 10.1155/2022/5361241
Abstract: Ferroptosis is a type of regulated cell death that displays a promising therapeutic pathway for drug-resistant tumor cells. However, some pancreatic cancer (PC) cells are less sensitive to erastin-induced ferroptosis, and normal pancreatic cells are… read more here.
Keywords: pancreatic cancer; vitamin; erastin induced; induced ferroptosis ... See more keywords
Xanthohumol Protects the Rat Myocardium against Ischemia/Reperfusion Injury-Induced Ferroptosis
Sign Up to like & getrecommendations! Published in 2022 at "Oxidative Medicine and Cellular Longevity"
DOI: 10.1155/2022/9523491
Abstract: Ferroptosis is an iron-dependent form of cell death caused by the inactivation of glutathione peroxidase 4 (GPX4) and accumulation of lipid peroxides. Ferroptosis has been found to participate in the ischemia-reperfusion (I/R) injury, leading to… read more here.
Keywords: ischemia reperfusion; reperfusion injury; ferroptosis; induced ferroptosis ... See more keywords
Oridonin-induced ferroptosis and apoptosis: a dual approach to suppress the growth of osteosarcoma cells
Sign Up to like & getrecommendations! Published in 2024 at "BMC Cancer"
DOI: 10.1186/s12885-024-11951-1
Abstract: Osteosarcoma (OS) is one of the most common aggressive bone malignancy tumors in adolescents. With the application of new chemotherapy regimens, finding new and effective anti-OS drugs to coordinate program implementation is urgent for the… read more here.
Keywords: mitochondrial membrane; oridonin induced; oridonin; induced ferroptosis ... See more keywords