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   Articles with "induced ferroptosis" as a keyword



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1,3‐Dichloro‐2‐propanol induced ferroptosis through Nrf2/ARE signaling pathway in hepatocytes

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recommendations! Published in 2022 at "Environmental Toxicology"

DOI: 10.1002/tox.23615

Abstract: 1,3‐Dichloro‐2‐propanol (1,3‐DCP) is a representative chloropropane environmental contaminant with multiple toxicities. Ferroptosis is a novel iron‐dependent form of regulated cell death that is closely associated with the accumulation of lipid peroxides, Fe2+ and reactive oxygen… read more here.

Keywords: signaling pathway; nrf2 signaling; dichloro propanol; induced ferroptosis ... See more keywords
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DHA inhibits proliferation and induces ferroptosis of leukemia cells through autophagy dependent degradation of ferritin

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recommendations! Published in 2019 at "Free Radical Biology and Medicine"

DOI: 10.1016/j.freeradbiomed.2018.12.011

Abstract: ABSTRACT Dihydroartemisinin (DHA) has been shown to be capable of inhibiting cancer growth, whereas it remains largely elusive that the underlying molecular mechanism of DHA induced acute myeloid leukemia (AML) cell death. In the present… read more here.

Keywords: dha induced; ferroptosis; dha; iron ... See more keywords
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Resveratrol protected acrolein-induced ferroptosis and insulin secretion dysfunction via ER-stress- related PERK pathway in MIN6 cells.

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recommendations! Published in 2021 at "Toxicology"

DOI: 10.1016/j.tox.2021.153048

Abstract: Acrolein is a typical food and environmental pollutant and a risk factor for diabetes. The primary pathogenesis of diabetes is insulin deficiency and resistance. Ferroptosis is an iron-dependent cell death type, accompanying by lipid peroxide… read more here.

Keywords: min6 cells; insulin secretion; ferroptosis; stress ... See more keywords
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Silencing of lncRNA MALAT1 facilitates erastin-induced ferroptosis in endometriosis through miR-145-5p/MUC1 signaling

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recommendations! Published in 2022 at "Cell Death Discovery"

DOI: 10.1038/s41420-022-00975-w

Abstract: Endometriosis is a chronic disorder characterized by the implantation of endometrial glands and stroma outside the uterus. However, the pathogenesis of endometriosis is still unclear. To date, there is no fully effective treatment without trauma… read more here.

Keywords: muc1; mir 145; malat1; ferroptosis ... See more keywords
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Resveratrol Protects BEAS-2B Cells against Erastin-Induced Ferroptosis through the Nrf2/Keap1 Pathway

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recommendations! Published in 2022 at "Planta Medica"

DOI: 10.1055/a-1923-4399

Abstract: Abstract Ferroptosis is a newly discovered type of cell death that is different from other types of cell death morphologically and biologically. It is considered to play an important role in many pulmonary diseases. Currently,… read more here.

Keywords: resveratrol; induced ferroptosis; beas cells; cells erastin ... See more keywords
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Platycodin D regulates high glucose-induced ferroptosis of HK-2 cells through glutathione peroxidase 4 (GPX4)

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recommendations! Published in 2022 at "Bioengineered"

DOI: 10.1080/21655979.2022.2045834

Abstract: ABSTRACT Diabetic nephropathy (DN) is associated with inflammation. Platycodin D (PD) demonstrates anti-inflammatory activity. However, whether PD affects DN remains to be explored. Here, we aimed to discuss the role of PD in DN and… read more here.

Keywords: glucose induced; expression; gpx4 expression; induced ferroptosis ... See more keywords
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Vitamin C Sensitizes Pancreatic Cancer Cells to Erastin-Induced Ferroptosis by Activating the AMPK/Nrf2/HMOX1 Pathway

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recommendations! Published in 2022 at "Oxidative Medicine and Cellular Longevity"

DOI: 10.1155/2022/5361241

Abstract: Ferroptosis is a type of regulated cell death that displays a promising therapeutic pathway for drug-resistant tumor cells. However, some pancreatic cancer (PC) cells are less sensitive to erastin-induced ferroptosis, and normal pancreatic cells are… read more here.

Keywords: pancreatic cancer; vitamin; erastin induced; induced ferroptosis ... See more keywords
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Xanthohumol Protects the Rat Myocardium against Ischemia/Reperfusion Injury-Induced Ferroptosis

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recommendations! Published in 2022 at "Oxidative Medicine and Cellular Longevity"

DOI: 10.1155/2022/9523491

Abstract: Ferroptosis is an iron-dependent form of cell death caused by the inactivation of glutathione peroxidase 4 (GPX4) and accumulation of lipid peroxides. Ferroptosis has been found to participate in the ischemia-reperfusion (I/R) injury, leading to… read more here.

Keywords: ischemia reperfusion; reperfusion injury; ferroptosis; induced ferroptosis ... See more keywords
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Knockdown of SHP2 attenuated LPS-induced ferroptosis via downregulating ACSL4 expression in acute lung injury.

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recommendations! Published in 2023 at "Allergologia et immunopathologia"

DOI: 10.15586/aei.v51i3.856

Abstract: BACKGROUND Acute lung injury (ALI) is a complex disease with a high mortality. Src homology 2 (SH2)-containing protein tyrosine phosphatase 2 (SHP2) is a protein tyrosine phosphatase that participates in pathogenesis of multiple diseases. Nevertheless,… read more here.

Keywords: lung injury; lps; expression; induced ferroptosis ... See more keywords
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Sodium hydrosulfide inhibits hemin-induced ferroptosis and lipid peroxidation in BV2 cells via the CBS/H2S system.

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recommendations! Published in 2023 at "Cellular signalling"

DOI: 10.2139/ssrn.4224101

Abstract: Ferroptosis is a form of iron-dependent programmed cell death discovered in recent years that has been shown to be involved in diverse neurological disorders. Hydrogen sulfide (H2S) is an important signaling molecule with neuroprotective effects,… read more here.

Keywords: lipid peroxidation; induced ferroptosis; hemin induced; cbs h2s ... See more keywords

Knockdown of ferroportin accelerates erastin-induced ferroptosis in neuroblastoma cells.

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recommendations! Published in 2018 at "European review for medical and pharmacological sciences"

DOI: 10.26355/eurrev_201806_15267

Abstract: OBJECTIVE Ferroptosis is a new-found iron-dependent form of non-apoptotic regulated cell death (RCD), which is activated on therapy with several antitumor agents, but the potential mechanism remains unclear. Erastin, exhibiting selectivity for RAS-mutated cancer cells,… read more here.

Keywords: ferroptosis neuroblastoma; fpn; ferroptosis; iron ... See more keywords