Neferine attenuates doxorubicin‐induced fibrosis and hypertrophy in H9c2 cells
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Biochemical and Molecular Toxicology"
DOI: 10.1002/jbt.23054
Abstract: Doxorubicin (DOX), an anthracycline antineoplastic candidate is used to treat various malignancies. Around 41% of patients undergoing DOX treatment develop acute cardiotoxicity. Preventing DOX‐induced cardiac fibrosis and hypertrophy helps in evading cardiac remodeling leading to… read more here.
Keywords: hypertrophy; fibrosis hypertrophy; dox; h9c2 ... See more keywords
Melatonin suppresses ischemia-induced fibrosis by regulating miR-149.
Sign Up to like & getrecommendations! Published in 2020 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2020.02.090
Abstract: Ischemic injury is a major risk factor for fibrosis. However, the precise mechanisms by which fibrosis is regulated and induced under ischemic oxidative stress conditions are unknown. To address this, we investigated the effect of… read more here.
Keywords: fibrosis; mir 149; ischemia induced; melatonin ... See more keywords
Arecanut-induced fibrosis display dual phases of reorganising glycans and amides in skin extracellular matrix.
Sign Up to like & getrecommendations! Published in 2021 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2021.06.093
Abstract: The habit of chewing arecanut leads to fibrosis in the oral tissues, which can lead to cancer. Despite high mortality, fibrosis has limited clinical success owing to organ-specific variations, genetic predispositions, and slow progression. Fibrosis… read more here.
Keywords: phase; fibrosis; extracellular matrix; arecanut induced ... See more keywords
Exploring radiation-induced fibrosis: biological mechanisms and new frontiers in research and therapeutics.
Sign Up to like & getrecommendations! Published in 2025 at "International journal of radiation biology"
DOI: 10.1080/09553002.2025.2540353
Abstract: PURPOSE Radiation-induced fibrosis (RIF) is a significant long-term complication of radiotherapy, affecting many cancer patients months to years after treatment. Characterized by progressive tissue stiffening, loss of elasticity, and impaired organ function, RIF can deleteriously… read more here.
Keywords: radiation; radiation induced; rif; induced fibrosis ... See more keywords
Adipose-Derived Stromal Cell-based Therapies for Radiation-Induced Fibrosis.
Sign Up to like & getrecommendations! Published in 2022 at "Advances in wound care"
DOI: 10.1089/wound.2022.0103
Abstract: SIGNIFICANCE Half of all cancer patients receive radiation therapy as a component of their treatment regimen, and the most common resulting complication is radiation-induced fibrosis of the skin and soft tissue. This thickening of the… read more here.
Keywords: cell based; induced fibrosis; radiation; radiation induced ... See more keywords
P16 Patient reported outcomes of cancer survivors with radiation induced fibrosis
Sign Up to like & getrecommendations! Published in 2023 at "British Journal of Surgery"
DOI: 10.1093/bjs/znad101.188
Abstract: This study aims to better understand the lived experience of head and neck cancer survivors who suffer from radiation induced fibrosis (RIF). Recording the lived experience of RIF will better inform us on the use… read more here.
Keywords: patient reported; radiation induced; induced fibrosis; cancer ... See more keywords
334 Immuno-Modulatory Impact of Adipose-Derived Stem Cells on Radiation-Induced Fibrosis
Sign Up to like & getrecommendations! Published in 2024 at "British Journal of Surgery"
DOI: 10.1093/bjs/znae163.506
Abstract: Radiation-induced fibrosis (RIF) is a complication of radiotherapy that occurs 4-12 months post-radiotherapy, which is used to treat head and neck squamous cell carcinoma that has a high morbidity in patients undergoing treatment for malignancy.… read more here.
Keywords: derived stem; radiation; radiation induced; induced fibrosis ... See more keywords
Radiation‐induced fibrosis: Mechanisms and therapeutic strategies from an immune microenvironment perspective
Sign Up to like & getrecommendations! Published in 2024 at "Immunology"
DOI: 10.1111/imm.13788
Abstract: Radiation‐induced fibrosis (RIF) is a severe chronic complication of radiotherapy (RT) manifested by excessive extracellular matrix (ECM) components deposition within the irradiated area. The lung, heart, skin, jaw, pelvic organs and so on may be… read more here.
Keywords: therapeutic strategies; immune microenvironment; radiation induced; induced fibrosis ... See more keywords
Silica-induced fibrosis: an ancient response from the early metazoans
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Experimental Biology"
DOI: 10.1242/jeb.166405
Abstract: ABSTRACT Exposure to crystalline silica particles causes silicosis, an occupational disease leading to an overproduction of collagen in the lung. The first step of this pathology is characterized by the release of inflammatory mediators. Tumour… read more here.
Keywords: collagen; response; silica; silica induced ... See more keywords
Follistatin attenuates radiation-induced fibrosis in a murine model
Sign Up to like & getrecommendations! Published in 2017 at "PLoS ONE"
DOI: 10.1371/journal.pone.0173788
Abstract: Purpose Fibrosis can be a disabling, severe side effect of radiotherapy that can occur in patients, and for which there is currently no effective treatment. The activins, proteins which are members of the TGFβ superfamily,… read more here.
Keywords: fibrosis; follistatin; radiation induced; murine model ... See more keywords
Dihydroartemisinin Inhibits TGF-β-Induced Fibrosis in Human Tenon Fibroblasts via Inducing Autophagy
Sign Up to like & getrecommendations! Published in 2021 at "Drug Design, Development and Therapy"
DOI: 10.2147/dddt.s280322
Abstract: Background The formation of hypertrophic scars (HS) can result in the failure of glaucoma surgery, and fibrosis is known to be closely associated with the progression of HS. Dihydroartemisinin (DHA) has been reported to inhibit… read more here.
Keywords: human tenon; induced fibrosis; fibrosis; inducing autophagy ... See more keywords