Simulation of intracellular $$\hbox {Ca}^{2+}$$Ca2+ transients in osteoblasts induced by fluid shear stress and its application
Sign Up to like & getrecommendations! Published in 2017 at "Biomechanics and Modeling in Mechanobiology"
DOI: 10.1007/s10237-016-0833-y
Abstract: Intracellular $$\hbox {Ca}^{2+}$$Ca2+ transient induced by fluid shear stress (FSS) plays an important role in mechanical regulation of osteoblasts, but the cellular mechanism remains incompletely understood. Here, we constructed a mathematical model combined with experiments… read more here.
Keywords: shear stress; induced fluid; intracellular hbox; fluid shear ... See more keywords
Afatinib amplifies cAMP-induced fluid secretion in a mouse mini-gut model via TMEM16A-mediated fluid secretion and secretory cell differentiation
Sign Up to like & getrecommendations! Published in 2025 at "Scientific Reports"
DOI: 10.1038/s41598-025-14516-9
Abstract: Afatinib is an effective treatment of metastatic non-small cell lung cancer, despite the occurrence of its common gastrointestinal toxicities especially diarrheas, which lead to dose adjustments or treatment cessation in severe cases. Underlying mechanisms of… read more here.
Keywords: fluid secretion; treatment; induced fluid; afatinib ... See more keywords
Mitochondrial and Metabolic Adaptations to Exercise-Induced Fluid Shear Stress in Endothelial Cells
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DOI: 10.1249/jes.0000000000000289
Abstract: Exercise-mediated hemodynamic flow confers mitochondrial remodeling and metabolic reprogramming in the vascular endothelial cell. Recent studies have greatly advanced our understanding of the central role of mitochondria on endothelial function. Here, we propose a hypothesis… read more here.
Keywords: adaptations exercise; metabolic adaptations; exercise induced; induced fluid ... See more keywords
Activation of the Calcium Sensing Receptor Decreases Secretagogue-Induced Fluid Secretion in the Rat Small Intestine
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DOI: 10.3389/fphys.2019.00439
Abstract: Background The calcium-sensing receptor (CaSR) has been localized and characterized in numerous tissues throughout the body. In the mammalian gastrointestinal tract, the CaSR is known to act as a nutrient sensor and has recently been… read more here.
Keywords: secretion; induced fluid; fluid secretion; secretagogue ... See more keywords