The Genetic Architecture of Diet‐Induced Hepatic Fibrosis in Mice: A Public Health Perspective
Sign Up to like & getrecommendations! Published in 2018 at "Hepatology"
DOI: 10.1002/hep.30207
Abstract: The recently published article by Hui et al. emphasizes the public health significance of diet-induced hepatic fibrosis; the research group elegantly highlighted the sophisticated and high-throughput genetic analysis of a "humanized" hyperlipidemic mouse model for progressive… read more here.
Keywords: fibrosis; diet induced; hepatic fibrosis; public health ... See more keywords
Ameliorative effect of nanoencapsulated flavonoid against chlorpyrifos‐induced hepatic oxidative damage and immunotoxicity in Wistar rats
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Biochemical and Molecular Toxicology"
DOI: 10.1002/jbt.22050
Abstract: The theme of the present work is to evaluate the protective effect of nanoencapsulated quercetin (NEQ) against chlorpyrifos (CPF)‐induced hepatic damage and immune alterations in animals. Nanoparticles (NP) drug encapsulation was prepared. Forty male Wistar… read more here.
Keywords: oxidative damage; effect nanoencapsulated; damage; wistar rats ... See more keywords
Montelukast abrogates prednisolone‐induced hepatic injury in rats: Modulation of mitochondrial dysfunction, oxidative/nitrosative stress, and apoptosis
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Biochemical and Molecular Toxicology"
DOI: 10.1002/jbt.22231
Abstract: The aim of this study was to investigate the protective effect of montelukast (MTK) against prednisolone‐induced hepatic injury in rats. Twenty‐eight male albino rats were categorized into four equal groups. Group I served as the… read more here.
Keywords: oxidative nitrosative; prednisolone induced; induced hepatic; nitrosative stress ... See more keywords
AMPK activation ameliorates fine particulate matter-induced hepatic injury
Sign Up to like & getrecommendations! Published in 2020 at "Environmental Science and Pollution Research"
DOI: 10.1007/s11356-020-08624-4
Abstract: Both the epidemiological and animal experimental studies have reported the association between PM 2.5 and respiratory, cardiovascular, and metabolic diseases. However, the study linking PM 2.5 and hepatic injury is few, and the relative mechanism… read more here.
Keywords: bat; ampk activation; induced hepatic; injury ... See more keywords
Acute fructose intake suppresses fasting-induced hepatic gluconeogenesis through the AKT-FoxO1 pathway
Sign Up to like & getrecommendations! Published in 2019 at "Biochemistry and Biophysics Reports"
DOI: 10.1016/j.bbrep.2019.100638
Abstract: Excessive intake of fructose increases lipogenesis in the liver, leading to hepatic lipid accumulation and development of fatty liver disease. Metabolic alterations in the liver due to fructose intake have been reported in many studies,… read more here.
Keywords: fructose administration; hepatic gluconeogenesis; fasting induced; induced hepatic ... See more keywords
Oroxylin A prevents alcohol-induced hepatic steatosis through inhibition of hypoxia inducible factor 1alpha.
Sign Up to like & getrecommendations! Published in 2018 at "Chemico-biological interactions"
DOI: 10.1016/j.cbi.2018.02.025
Abstract: Accumulating data reveal that oroxylin A has beneficial effects against chronic liver disease. The previously studies showed oroxylin A, a flavonoid extracted from Scutellariae radix, improved acute liver injury and accelerated liver regeneration in vivo.… read more here.
Keywords: alcohol induced; induced hepatic; oroxylin; hepatic steatosis ... See more keywords
Melatonin mitigates thioacetamide‐induced hepatic fibrosis via antioxidant activity and modulation of proinflammatory cytokines and fibrogenic genes
Sign Up to like & getrecommendations! Published in 2018 at "Life Sciences"
DOI: 10.1016/j.lfs.2017.11.036
Abstract: Aims: The potential antifibrotic effects of melatonin against induced hepatic fibrosis were explored. Main methods: Rats were allocated into four groups: placebo; thioacetamide (TAA) (200 mg/kg bwt, i.p twice weekly for two months); melatonin (5… read more here.
Keywords: proinflammatory; proinflammatory cytokines; fibrogenic genes; hepatic fibrosis ... See more keywords
The miR-139-5p/peripheral myelin protein 22 axis modulates TGF-β-induced hepatic stellate cell activation and CCl4-induced hepatic fibrosis in mice.
Sign Up to like & getrecommendations! Published in 2021 at "Life sciences"
DOI: 10.1016/j.lfs.2021.119294
Abstract: Hepatic stellate cells (HSCs) are the major source of extracellular matrix (ECM)-producing myofibroblasts. When activated by multiple injuries, HSCs become proliferative, contractile, inflammatory and chemotactic and are characterized by enhanced ECM production, which plays a… read more here.
Keywords: mir 139; pmp22; tgf induced; activation ... See more keywords
Syringic acid protects against thioacetamide-induced hepatic encephalopathy: Behavioral, biochemical, and molecular evidence
Sign Up to like & getrecommendations! Published in 2022 at "Neuroscience Letters"
DOI: 10.1016/j.neulet.2021.136385
Abstract: The objective of this study was to elucidate the effects of syringic acid on thioacetamide-induced hepatic encephalopathy which is a complex serious syndrome with neuropsychiatric abnormalities related to acute liver dysfunctions like cirrhosis. Rats were… read more here.
Keywords: thioacetamide induced; induced hepatic; acid; hepatic encephalopathy ... See more keywords
Multiomics Analysis Revealed the Molecular Mechanism of miRNAs in Fluoride-Induced Hepatic Glucose and Lipid Metabolism Disorders.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.2c03049
Abstract: Fluoride-induced liver injury seriously endangers human and animal health and animal food safety, but the underlying mechanism remains unclear. This study aims to explore the mechanism of miRNAs in fluoride-induced hepatic glycolipid metabolism disorders. C57… read more here.
Keywords: metabolism; mirnas fluoride; fluoride induced; mechanism mirnas ... See more keywords
Adiponectin deficiency rescues high-fat diet-induced hepatic injury, apoptosis and autophagy loss despite persistent steatosis
Sign Up to like & getrecommendations! Published in 2017 at "International Journal of Obesity"
DOI: 10.1038/ijo.2017.128
Abstract: Background &aims:Low levels of adiponectin (APN), an adipose-derived adipokine, are associated with obesity and non-alcoholic steatohepatitis although its role in high-fat diet-induced hepatic injury and steatosis remains unclear. Here we hypothesized that APN deficiency alters… read more here.
Keywords: fat diet; diet induced; high fat; steatosis ... See more keywords