Cell Aggregation Culture Induces Functional Differentiation of Induced Hepatocyte-like Cells through Activation of Hippo Signaling.
Sign Up to like & getrecommendations! Published in 2018 at "Cell reports"
DOI: 10.1016/j.celrep.2018.09.010
Abstract: Recent progress in direct lineage reprogramming has enabled the generation of induced hepatocyte-like (iHep) cells and revealed their potential as an alternative to hepatocytes for medical applications. However, the hepatic functions of iHep cells are… read more here.
Keywords: induced hepatocyte; hepatocyte like; cells activation; ihep ... See more keywords
SIRT1 alleviates isoniazid-induced hepatocyte injury by reducing histone acetylation in the IL-6 promoter region.
Sign Up to like & getrecommendations! Published in 2019 at "International immunopharmacology"
DOI: 10.1016/j.intimp.2018.11.054
Abstract: Silent information regulator 1 (SIRT1) is a type III histone deacetylase that is related to the inhibition of the inflammatory response. The aim of this study was to investigate the regulation of SIRT1 on isoniazid-induced… read more here.
Keywords: sirt1; induced hepatocyte; hepatocyte injury; isoniazid induced ... See more keywords
Metastable Reprogramming State of Single Transcription Factor-Derived Induced Hepatocyte-Like Cells
Sign Up to like & getrecommendations! Published in 2019 at "Stem Cells International"
DOI: 10.1155/2019/6937257
Abstract: We previously described the generation of induced hepatocyte-like cells (iHeps) using the hepatic transcription factor Hnf1a together with small molecules. These iHeps represent a hepatic state that is more mature compared with iHeps generated with… read more here.
Keywords: state; induced hepatocyte; hnf1a; hepatocyte like ... See more keywords
Quercetin Protects Ethanol-Induced Hepatocyte Pyroptosis via Scavenging Mitochondrial ROS and Promoting PGC-1α-Regulated Mitochondrial Homeostasis in L02 Cells
Sign Up to like & getrecommendations! Published in 2022 at "Oxidative Medicine and Cellular Longevity"
DOI: 10.1155/2022/4591134
Abstract: Alcoholic liver disease (ALD) is a multifaceted process that involves excessive lipid, reactive oxygen species (ROS) production, unbalanced mitochondrial homeostasis, and ultimate cell death. Quercetin is a dietary phytochemical presented in various fruits and vegetables,… read more here.
Keywords: induced hepatocyte; ethanol induced; pyroptosis; mitochondrial homeostasis ... See more keywords
Necroptosis Is a Mechanism of Death in Mouse Induced Hepatocyte-Like Cells Reprogrammed from Mouse Embryonic Fibroblasts
Sign Up to like & getrecommendations! Published in 2018 at "Molecules and Cells"
DOI: 10.14348/molcells.2018.2353
Abstract: Liver transplantation is recommended for patients with liver failure, but liver donors are limited. This necessitates the development of artificial livers, and hepatocytes are necessary to develop such artificial livers. Although induced hepatocyte-like cells are… read more here.
Keywords: embryonic fibroblasts; mouse induced; induced hepatocyte; hepatocyte like ... See more keywords
Autophagy activation by Jiang Zhi Granule protects against metabolic stress-induced hepatocyte injury
Sign Up to like & getrecommendations! Published in 2018 at "World Journal of Gastroenterology"
DOI: 10.3748/wjg.v24.i9.992
Abstract: AIM To elucidate the potential role of autophagy and the protective effects of Jiang Zhi Granule (JZG) in metabolic stress-induced hepatocyte injury. METHODS An in vitro and in vivo approach was used in this study.… read more here.
Keywords: induced hepatocyte; jzg; stress induced; stress ... See more keywords
Differentiated modulation of signaling molecules AMPK and SIRT1 in experimentally drug-induced hepatocyte injury.
Sign Up to like & getrecommendations! Published in 2022 at "Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia"
DOI: 10.5507/bp.2022.018
Abstract: AIM Currently available medicines have little to offer in terms of supporting the regeneration of injured hepatic cells. Previous experimental studies have shown that resveratrol and metformin, less specific activators of AMP-activated protein kinase (AMPK)… read more here.
Keywords: induced hepatocyte; modulation; ampk sirt1; injury ... See more keywords