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   Articles with "induced hepatocyte" as a keyword



Cell Aggregation Culture Induces Functional Differentiation of Induced Hepatocyte-like Cells through Activation of Hippo Signaling.

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recommendations! Published in 2018 at "Cell reports"

DOI: 10.1016/j.celrep.2018.09.010

Abstract: Recent progress in direct lineage reprogramming has enabled the generation of induced hepatocyte-like (iHep) cells and revealed their potential as an alternative to hepatocytes for medical applications. However, the hepatic functions of iHep cells are… read more here.

Keywords: induced hepatocyte; hepatocyte like; cells activation; ihep ... See more keywords

SIRT1 alleviates isoniazid-induced hepatocyte injury by reducing histone acetylation in the IL-6 promoter region.

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recommendations! Published in 2019 at "International immunopharmacology"

DOI: 10.1016/j.intimp.2018.11.054

Abstract: Silent information regulator 1 (SIRT1) is a type III histone deacetylase that is related to the inhibition of the inflammatory response. The aim of this study was to investigate the regulation of SIRT1 on isoniazid-induced… read more here.

Keywords: sirt1; induced hepatocyte; hepatocyte injury; isoniazid induced ... See more keywords

Hongjingtian alleviates arsenic-induced hepatocyte injury by inhibiting oxidative stress and endoplasmic reticulum stress

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recommendations! Published in 2025 at "Journal of Asian Natural Products Research"

DOI: 10.1080/10286020.2025.2481290

Abstract: Abstract This study explored Hongjingtian’s (HJT) protective effects against arsenic-induced hepatotoxicity. NaAsO2 (8 μM, 24 h)-damaged hepatocytes treated with HJT (50/100 mg/L) showed restored cell viability via CCK-8/LDH assays. HJT reduced arsenic-induced ROS, improved mitochondrial membrane potential, elevated… read more here.

Keywords: reticulum stress; arsenic induced; induced hepatocyte; stress ... See more keywords

Metastable Reprogramming State of Single Transcription Factor-Derived Induced Hepatocyte-Like Cells

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recommendations! Published in 2019 at "Stem Cells International"

DOI: 10.1155/2019/6937257

Abstract: We previously described the generation of induced hepatocyte-like cells (iHeps) using the hepatic transcription factor Hnf1a together with small molecules. These iHeps represent a hepatic state that is more mature compared with iHeps generated with… read more here.

Keywords: state; induced hepatocyte; hnf1a; hepatocyte like ... See more keywords

Quercetin Protects Ethanol-Induced Hepatocyte Pyroptosis via Scavenging Mitochondrial ROS and Promoting PGC-1α-Regulated Mitochondrial Homeostasis in L02 Cells

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recommendations! Published in 2022 at "Oxidative Medicine and Cellular Longevity"

DOI: 10.1155/2022/4591134

Abstract: Alcoholic liver disease (ALD) is a multifaceted process that involves excessive lipid, reactive oxygen species (ROS) production, unbalanced mitochondrial homeostasis, and ultimate cell death. Quercetin is a dietary phytochemical presented in various fruits and vegetables,… read more here.

Keywords: induced hepatocyte; ethanol induced; pyroptosis; mitochondrial homeostasis ... See more keywords
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Necroptosis Is a Mechanism of Death in Mouse Induced Hepatocyte-Like Cells Reprogrammed from Mouse Embryonic Fibroblasts

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recommendations! Published in 2018 at "Molecules and Cells"

DOI: 10.14348/molcells.2018.2353

Abstract: Liver transplantation is recommended for patients with liver failure, but liver donors are limited. This necessitates the development of artificial livers, and hepatocytes are necessary to develop such artificial livers. Although induced hepatocyte-like cells are… read more here.

Keywords: embryonic fibroblasts; mouse induced; induced hepatocyte; hepatocyte like ... See more keywords

Whey protein hydrolysate alleviated acetaminophen-induced hepatocyte pyroptosis by activating mitophagy.

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recommendations! Published in 2025 at "Journal of dairy science"

DOI: 10.3168/jds.2025-26625

Abstract: Whey protein is widely recognized as a high-quality protein source, primarily derived from dairy products. This type of protein is valued not only for its remarkable nutritional benefits but also for its substantial antioxidant properties… read more here.

Keywords: induced hepatocyte; whey protein; protein hydrolysate; pyroptosis ... See more keywords

Quercetin alleviates rifampicin-induced hepatocyte injury by modulating the Hippo-YAP signaling pathway

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recommendations! Published in 2025 at "Frontiers in Medicine"

DOI: 10.3389/fmed.2025.1707248

Abstract: Objective To investigate the protective effects of Quercetin, an antioxidant and anti-apoptotic flavonoid, against rifampicin (RFP)-induced hepatocyte injury via the Hippo-YAP signaling pathway. Methods A rifampicin-induced hepatocyte injury model was established using HepaRG cells. HepaRG… read more here.

Keywords: induced hepatocyte; apoptosis; hippo yap; hepatocyte injury ... See more keywords
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Protective Effects of Cereal Grain Extracts on Alcohol-Induced Hepatocyte Damage

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recommendations! Published in 2024 at "Preventive Nutrition and Food Science"

DOI: 10.3746/pnf.2024.29.1.40

Abstract: This study investigated the protective effects of cereal grains on alcohol-induced hepatocyte damage. Cereal grains were extracted with methanol, and their radical scavenging properties and total phenolic contents were examined. Black rice extract exhibited the… read more here.

Keywords: alcohol induced; protective effects; cereal grains; induced hepatocyte ... See more keywords

Autophagy activation by Jiang Zhi Granule protects against metabolic stress-induced hepatocyte injury

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recommendations! Published in 2018 at "World Journal of Gastroenterology"

DOI: 10.3748/wjg.v24.i9.992

Abstract: AIM To elucidate the potential role of autophagy and the protective effects of Jiang Zhi Granule (JZG) in metabolic stress-induced hepatocyte injury. METHODS An in vitro and in vivo approach was used in this study.… read more here.

Keywords: induced hepatocyte; jzg; stress induced; stress ... See more keywords

Differentiated modulation of signaling molecules AMPK and SIRT1 in experimentally drug-induced hepatocyte injury.

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recommendations! Published in 2022 at "Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia"

DOI: 10.5507/bp.2022.018

Abstract: AIM Currently available medicines have little to offer in terms of supporting the regeneration of injured hepatic cells. Previous experimental studies have shown that resveratrol and metformin, less specific activators of AMP-activated protein kinase (AMPK)… read more here.

Keywords: induced hepatocyte; modulation; ampk sirt1; injury ... See more keywords