Mannan‐binding lectin attenuates acetaminophen‐induced hepatotoxicity by regulating CYP2E1 expression via ROS‐dependent JNK/SP1 pathway
Sign Up to like & getrecommendations! Published in 2019 at "European Journal of Immunology"
DOI: 10.1002/eji.201847830
Abstract: Mannan‐binding lectin (MBL) acts as a soluble pattern recognition molecule in the innate immune system, which is primarily produced by the liver. MBL deficiency occurs with high frequency in the population and is reported to… read more here.
Keywords: binding lectin; induced hepatotoxicity; mbl; expression ... See more keywords
Curcumin attenuates isoniazid‐induced hepatotoxicity by upregulating the SIRT1/PGC‐1α/NRF1 pathway
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Applied Toxicology"
DOI: 10.1002/jat.4288
Abstract: As a serious infectious disease, tuberculosis threatens global public health. Isoniazid is the first‐line drug not only in active tuberculosis but also in its prevention. Severe hepatotoxicity greatly limits its use. Curcumin, extracted from turmeric,… read more here.
Keywords: sirt1 pgc; isoniazid induced; curcumin; hepatotoxicity ... See more keywords
Therapeutic potential of carfilzomib, an irreversible proteasome inhibitor, against acetaminophen‐induced hepatotoxicity in mice
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Biochemical and Molecular Toxicology"
DOI: 10.1002/jbt.21877
Abstract: Overdose of acetaminophen (APAP) is often associated with hepatotoxicity. Carfilzomib (CFZ) shows multiple pharmacological activities including anti‐inflammatory potential. Therefore, this study was undertaken to evaluate the possible therapeutic effects of CFZ against APAP‐induced hepatotoxicity. Hepatotoxicity… read more here.
Keywords: induced hepatotoxicity; cfz post; hepatotoxicity; therapeutic potential ... See more keywords
Apigenin alleviated acetaminophen‐induced hepatotoxicity in low protein‐fed rats: Targeting oxidative stress, STAT3, and apoptosis signals
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Biochemical and Molecular Toxicology"
DOI: 10.1002/jbt.22472
Abstract: Apigenin (API) is a natural flavonoid abundant in fruits and vegetables. The present study was undertaken to evaluate the effect of protein malnutrition (PMN) on acetaminophen (APAP)‐induced hepatotoxicity, together with the protective effects of API,… read more here.
Keywords: protein; fed rats; induced hepatotoxicity; low protein ... See more keywords
Hepatoprotective effect of arjunolic acid against cisplatin‐induced hepatotoxicity: Targeting oxidative stress, inflammation, and apoptosis
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Biochemical and Molecular Toxicology"
DOI: 10.1002/jbt.22714
Abstract: Minimizing the adverse effects of chemotherapeutic agents remains a therapeutic challenge. Cisplatin (CP) induces hepatotoxicity through activation of oxidative stress, inflammation, and apoptosis cascades which is considered a significant drawback. Thus, this study aimed to… read more here.
Keywords: induced hepatotoxicity; group; hepatotoxicity; inflammation apoptosis ... See more keywords
Therapeutic effects of atorvastatin on doxorubicin-induced hepatotoxicity in rats via antioxidative damage, anti-inflammatory, and anti-lipotoxicity.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of biochemical and molecular toxicology"
DOI: 10.1002/jbt.23329
Abstract: Doxorubicin (DOX), is a high efficiency anthracycline antitumor drug. However, the clinical application of DOX is limited mainly by dose‐related adverse drug reactions. Currently, the therapeutic effects of Atorvastatin (ATO) on DOX‐induced hepatotoxicity were studied… read more here.
Keywords: therapeutic effects; dox; doxorubicin; effects atorvastatin ... See more keywords
Hepatoprotective effects of phosphatidylserine liposomes on carbon tetrachloride‐induced hepatotoxicity in rats
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.28464
Abstract: It has been proposed carbon tetrachloride (CCl4) intoxication due to the production of free radicals and serum levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT), and alkaline phosphatase (ALP) overload results hepatotoxicity. Phosphatidylserine (PS) has… read more here.
Keywords: induced hepatotoxicity; hepatoprotective effects; carbon tetrachloride; hepatotoxicity rats ... See more keywords
Noninvasive Assessment of APAP (N‐acetyl‐p‐aminophenol)‐Induced Hepatotoxicity Using Multiple MRI Parameters in an Experimental Rat Model
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Magnetic Resonance Imaging"
DOI: 10.1002/jmri.28203
Abstract: Early detection and accurate assessment of N‐acetyl‐p‐aminophenol (APAP)‐induced hepatotoxicity can prevent further aggravation of liver injury and reduce the incidence of liver failure. read more here.
Keywords: apap; assessment; acetyl aminophenol; induced hepatotoxicity ... See more keywords
Vitamin K protects against 7,12‐dimethylbenz(A)anthracene induced hepatotoxicity in Wistar rats
Sign Up to like & getrecommendations! Published in 2020 at "Environmental Toxicology"
DOI: 10.1002/tox.23042
Abstract: Humans are daily exposed to 7,12‐dimethylbenz(a)anthracene (DMBA), a well known polycyclic aromatic hydrocarbons (PAH). This study investigated the role of dietary intake of Vitamin K (VK), a polyphenolic compound, with potential antioxidative properties, against DMBA‐induced… read more here.
Keywords: induced hepatotoxicity; dimethylbenz anthracene; dmba; wistar rats ... See more keywords
Multiple microRNAs function as self-protective modules in acetaminophen-induced hepatotoxicity in humans
Sign Up to like & getrecommendations! Published in 2017 at "Archives of Toxicology"
DOI: 10.1007/s00204-017-2090-y
Abstract: Acetaminophen (APAP) overdose is the leading cause of acute liver failure. Yet the mechanisms underlying adaptive tolerance toward APAP-induced liver injury are not fully understood. To better understand molecular mechanisms contributing to adaptive tolerance to… read more here.
Keywords: induced hepatotoxicity; hsa mir; expression; hsa ... See more keywords
Autophagy alleviates amiodarone-induced hepatotoxicity
Sign Up to like & getrecommendations! Published in 2020 at "Archives of Toxicology"
DOI: 10.1007/s00204-020-02837-9
Abstract: Amiodarone is a widely used antiarrhythmic drug that can cause the development of steatohepatitis as well as liver fibrosis and cirrhosis. The molecular mechanisms of amiodarone-mediated liver injury remain largely unknown. We therefore analyzed amiodarone-mediated… read more here.
Keywords: autophagy alleviates; amiodarone; amiodarone mediated; amiodarone induced ... See more keywords