Mannan‐binding lectin attenuates acetaminophen‐induced hepatotoxicity by regulating CYP2E1 expression via ROS‐dependent JNK/SP1 pathway
Sign Up to like & getrecommendations! Published in 2019 at "European Journal of Immunology"
DOI: 10.1002/eji.201847830
Abstract: Mannan‐binding lectin (MBL) acts as a soluble pattern recognition molecule in the innate immune system, which is primarily produced by the liver. MBL deficiency occurs with high frequency in the population and is reported to… read more here.
Keywords: binding lectin; induced hepatotoxicity; mbl; expression ... See more keywords
Curcumin attenuates isoniazid‐induced hepatotoxicity by upregulating the SIRT1/PGC‐1α/NRF1 pathway
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Applied Toxicology"
DOI: 10.1002/jat.4288
Abstract: As a serious infectious disease, tuberculosis threatens global public health. Isoniazid is the first‐line drug not only in active tuberculosis but also in its prevention. Severe hepatotoxicity greatly limits its use. Curcumin, extracted from turmeric,… read more here.
Keywords: sirt1 pgc; isoniazid induced; curcumin; hepatotoxicity ... See more keywords
Therapeutic potential of carfilzomib, an irreversible proteasome inhibitor, against acetaminophen‐induced hepatotoxicity in mice
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Biochemical and Molecular Toxicology"
DOI: 10.1002/jbt.21877
Abstract: Overdose of acetaminophen (APAP) is often associated with hepatotoxicity. Carfilzomib (CFZ) shows multiple pharmacological activities including anti‐inflammatory potential. Therefore, this study was undertaken to evaluate the possible therapeutic effects of CFZ against APAP‐induced hepatotoxicity. Hepatotoxicity… read more here.
Keywords: induced hepatotoxicity; cfz post; hepatotoxicity; therapeutic potential ... See more keywords
Apigenin alleviated acetaminophen‐induced hepatotoxicity in low protein‐fed rats: Targeting oxidative stress, STAT3, and apoptosis signals
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Biochemical and Molecular Toxicology"
DOI: 10.1002/jbt.22472
Abstract: Apigenin (API) is a natural flavonoid abundant in fruits and vegetables. The present study was undertaken to evaluate the effect of protein malnutrition (PMN) on acetaminophen (APAP)‐induced hepatotoxicity, together with the protective effects of API,… read more here.
Keywords: protein; fed rats; induced hepatotoxicity; low protein ... See more keywords
Hepatoprotective effect of arjunolic acid against cisplatin‐induced hepatotoxicity: Targeting oxidative stress, inflammation, and apoptosis
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Biochemical and Molecular Toxicology"
DOI: 10.1002/jbt.22714
Abstract: Minimizing the adverse effects of chemotherapeutic agents remains a therapeutic challenge. Cisplatin (CP) induces hepatotoxicity through activation of oxidative stress, inflammation, and apoptosis cascades which is considered a significant drawback. Thus, this study aimed to… read more here.
Keywords: induced hepatotoxicity; group; hepatotoxicity; inflammation apoptosis ... See more keywords
Therapeutic effects of atorvastatin on doxorubicin-induced hepatotoxicity in rats via antioxidative damage, anti-inflammatory, and anti-lipotoxicity.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of biochemical and molecular toxicology"
DOI: 10.1002/jbt.23329
Abstract: Doxorubicin (DOX), is a high efficiency anthracycline antitumor drug. However, the clinical application of DOX is limited mainly by dose‐related adverse drug reactions. Currently, the therapeutic effects of Atorvastatin (ATO) on DOX‐induced hepatotoxicity were studied… read more here.
Keywords: therapeutic effects; dox; doxorubicin; effects atorvastatin ... See more keywords
The protective effects of esculetin against Doxorubicin‐Induced hepatotoxicity in rats: Insights into the modulation of Caspase, FOXOs, and heat shock protein pathways
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Biochemical and Molecular Toxicology"
DOI: 10.1002/jbt.23861
Abstract: Doxorubicin (DOX) is an anthracycline antibiotic widely employed to treat carcinoma. Nevertheless, severe cardiotoxic side effects restrict its clinical use. Esculetin, a natural flavonoid, is found abundantly in plants. This study evaluated the protective effects… read more here.
Keywords: dox esculetin; dox; induced hepatotoxicity; protective effects ... See more keywords
Ferroptosis and Lipid Peroxidation Participate in Valproic Acid‐Induced Hepatotoxicity via the Long‐chain Acyl‐CoA Synthetase 4/Glutathione Peroxidase 4 Pathway
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Biochemical and Molecular Toxicology"
DOI: 10.1002/jbt.70484
Abstract: Valproic acid (VPA) is a commonly prescribed antiepileptic drug, with hepatotoxicity being one of its most frequent and severe adverse effects. The underlying mechanisms of VPA‐induced hepatotoxicity remain elusive. Thus, this study aimed to investigate… read more here.
Keywords: vpa; induced hepatotoxicity; vpa induced; ferroptosis ... See more keywords
Network Toxicology and Molecular Docking Analysis of Antituberculosis Drug‐Induced Hepatotoxicity
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Biochemical and Molecular Toxicology"
DOI: 10.1002/jbt.70602
Abstract: Drug‐induced hepatotoxicity (DIH) is a serious adverse effect of Antituberculosis (anti‐TB) therapy, frequently causing treatment interruption and poor outcomes. This study combines network toxicology, molecular docking technology, and in vivo experiments to clarify the molecular… read more here.
Keywords: molecular docking; drug induced; drug; toxicology ... See more keywords
Hepatoprotective effects of phosphatidylserine liposomes on carbon tetrachloride‐induced hepatotoxicity in rats
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.28464
Abstract: It has been proposed carbon tetrachloride (CCl4) intoxication due to the production of free radicals and serum levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT), and alkaline phosphatase (ALP) overload results hepatotoxicity. Phosphatidylserine (PS) has… read more here.
Keywords: induced hepatotoxicity; hepatoprotective effects; carbon tetrachloride; hepatotoxicity rats ... See more keywords
Noninvasive Assessment of APAP (N‐acetyl‐p‐aminophenol)‐Induced Hepatotoxicity Using Multiple MRI Parameters in an Experimental Rat Model
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Magnetic Resonance Imaging"
DOI: 10.1002/jmri.28203
Abstract: Early detection and accurate assessment of N‐acetyl‐p‐aminophenol (APAP)‐induced hepatotoxicity can prevent further aggravation of liver injury and reduce the incidence of liver failure. read more here.
Keywords: apap; assessment; acetyl aminophenol; induced hepatotoxicity ... See more keywords