Linalool May Exert Neuroprotective Effects Against Cadmium-Induced Hippocampal Neurodegeneration by Regulating the 4-HNE/NF-κB Signaling Pathway
Sign Up to like & getrecommendations! Published in 2025 at "Biological Trace Element Research"
DOI: 10.1007/s12011-025-04734-7
Abstract: Cadmium (Cd) is a prevalent industrial and environmental contaminant that accumulates in the tissues of animals and humans. In particular, one of the regions most affected by Cd-induced neurodegeneration is the hippocampus. Linalool (Lin) is… read more here.
Keywords: hippocampal neurodegeneration; induced hippocampal; neuroprotective effects; neurodegeneration ... See more keywords
Exercise-Induced Hippocampal Neurogenesis Is Attenuated by Inhibition of Monocarboxylate Transporter 2
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DOI: 10.1007/s12035-025-04986-3
Abstract: Several studies have suggested that lactate mediates exercise-induced hippocampal neurogenesis. To investigate this, we used a monocarboxylate transporter (MCT) inhibitor, alpha-cyano-4-hydroxycinnamic acid (4CIN), to attenuate the signaling effect of endogenous lactate in the hippocampus. Ten-week-old… read more here.
Keywords: neurogenesis; inhibition; exercise induced; exercise ... See more keywords
Autophagy-regulated AMPAR subunit upregulation in in vitro oxygen glucose deprivation/reoxygenation-induced hippocampal injury
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DOI: 10.1016/j.brainres.2017.05.019
Abstract: Autophagy has been implicated to mediate experimental cerebral ischemia/reperfusion-induced neuronal death; the underlying molecular mechanisms, though, are poorly understood. In this study, we investigated the role of autophagy in regulating the expression of AMPAR subunits… read more here.
Keywords: glucose deprivation; induced hippocampal; autophagy; oxygen glucose ... See more keywords
CGA restrains the apoptosis of Aβ25-35-induced hippocampal neurons
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DOI: 10.1080/00207454.2019.1702547
Abstract: Abstract Background: Chlorogenic acid (CGA) has anti-oxidant and anti-inflammatory effects, but the study on its role in Alzheimer’s disease (AD) models remains rare. Here, the effects of CGA on β-amyloid protein (Aβ)-induced cell models were… read more here.
Keywords: hippocampal neurons; apoptosis; apoptosis induced; cga restrains ... See more keywords
The effect and mechanism of cypermethrin-induced hippocampal neurotoxicity as determined by network pharmacology analysis and experimental validation.
Sign Up to like & getrecommendations! Published in 2021 at "Bioengineered"
DOI: 10.1080/21655979.2021.2000106
Abstract: Cypermethrin (CMN) is a widely used artificial synthetic pesticide that causes neurotoxicity in the hippocampus. However, the underlying toxicological targets and mechanisms remain unclear. In this study, network pharmacology analysis and in vitro models were… read more here.
Keywords: mechanism; pharmacology; induced hippocampal; network pharmacology ... See more keywords