Comparison of pregabalin with magnesium sulfate in the prevention of remifentanil‐induced hyperalgesia in patients undergoing rhinoplasty: A randomized clinical trial
Sign Up to like & getrecommendations! Published in 2022 at "Laryngoscope Investigative Otolaryngology"
DOI: 10.1002/lio2.905
Abstract: Remifentanil is usually used for controlled hypotension during rhinoplasty under general anesthesia (G/A). One of the complications of the remifentanil is postoperative hyperalgesia. In this study, we compare the effectiveness of pregabalin with that of… read more here.
Keywords: remifentanil; prevention; induced hyperalgesia; remifentanil induced ... See more keywords
Dexmedetomidine Alleviates Remifentanil-Induced Hyperalgesia in Rats by Modulating the P2 X 4/BDNF Pathway
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DOI: 10.1007/s11064-025-04377-z
Abstract: In the clinical settings, patients often develop opioid-induced hyperalgesia (OIH) after utilization of high dose intra-operative remifentanil. It is widely considered that systemic α2 agonists, including dexmedetomidine (DEX), have the potential to mitigate postoperative pain… read more here.
Keywords: induced hyperalgesia; alleviates remifentanil; dex; dexmedetomidine alleviates ... See more keywords
Spinal administration of the multi-functional opioid/neuropeptide FF agonist BN-9 produced potent antinociception without development of tolerance and opioid-induced hyperalgesia.
Sign Up to like & getrecommendations! Published in 2020 at "European journal of pharmacology"
DOI: 10.1016/j.ejphar.2020.173169
Abstract: Chronic opioids treatment is impeded by the development of analgesic tolerance and opioid-induced hyperalgesia. Recent studies have shown that multi-functional opioid compounds produce analgesic activities with limited side effects. We developed a novel multi-functional peptide… read more here.
Keywords: tolerance; multi functional; functional opioid; opioid induced ... See more keywords
Social defeat stress-induced hyperalgesia is mediated by nav 1.8+ nociceptive fibers
Sign Up to like & getrecommendations! Published in 2020 at "Neuroscience Letters"
DOI: 10.1016/j.neulet.2020.135006
Abstract: Recently the voltage-gated sodium (Nav) channels began to be studied as possible targets for analgesic drugs. In addition, specific Nav 1.8 blockers are currently being used to treat some types of chronic pain pathologies such… read more here.
Keywords: social defeat; nociceptive fibers; hyperalgesia; defeat stress ... See more keywords
Inhibition of Nerve Growth Factor Signaling Alleviates Repeated Dural Stimulation-induced Hyperalgesia in Rats
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DOI: 10.1016/j.neuroscience.2018.12.006
Abstract: Our previous study showed that acid-sensing ion channel 3 (ASIC3) in the trigeminal nucleus caudalis (TNC) is involved in the pathogenesis of recurrent migraine. ASIC3 is regulated by nerve growth factor (NGF), which induces hyperalgesia… read more here.
Keywords: repeated dural; dural stimulation; tnc; induced hyperalgesia ... See more keywords
Enhancing KCC2 function counteracts morphine-induced hyperalgesia
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DOI: 10.1038/s41598-017-04209-3
Abstract: Morphine-induced hyperalgesia (MIH) is a severe adverse effect accompanying repeated morphine treatment, causing a paradoxical decrease in nociceptive threshold. Previous reports associated MIH with a decreased expression of the Cl− extruder KCC2 in the superficial… read more here.
Keywords: morphine induced; treatment; sdh neurons; enhancing kcc2 ... See more keywords
Short-duration physical activity prevents the development of activity-induced hyperalgesia through opioid and serotoninergic mechanisms
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DOI: 10.1097/j.pain.0000000000000967
Abstract: Abstract Regular physical activity prevents the development of chronic muscle pain through the modulation of central mechanisms that involve rostral ventromedial medulla (RVM). We tested if pharmacological blockade or genetic deletion of mu-opioid receptors in… read more here.
Keywords: activity induced; sedentary mice; mice; rvm ... See more keywords
Activation of sphingosine-1-phosphate receptor subtype 1 in the central nervous system contributes to morphine-induced hyperalgesia and antinociceptive tolerance in rodents.
Sign Up to like & getrecommendations! Published in 2020 at "Pain"
DOI: 10.1097/j.pain.0000000000001888
Abstract: Morphine-induced alterations in sphingolipid metabolism in the spinal cord and increased formation of the bioactive sphingolipid metabolite sphingosine-1-phosphate (S1P) have been implicated in the development of morphine-induced hyperalgesia (OIH; increased pain sensitivity) and antinociceptive tolerance.… read more here.
Keywords: morphine induced; tolerance; morphine; sphingosine phosphate ... See more keywords
Case report: Comprehensive management of painful diabetic neuropathy—Addressing opioid-induced hyperalgesia through multimodal approaches
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DOI: 10.1097/md.0000000000039126
Abstract: Rationale: Diabetic neuropathy is a prevalent and debilitating complication of diabetes, necessitating effective pain management strategies. While pharmacological treatments, including opioids, are commonly employed, they pose significant challenges due to the risk of developing opioid-induced… read more here.
Keywords: induced hyperalgesia; report; diabetic neuropathy; opioid induced ... See more keywords
TRPV1 and spinal astrocyte activation contribute to remifentanil-induced hyperalgesia in rats.
Sign Up to like & getrecommendations! Published in 2019 at "NeuroReport"
DOI: 10.1097/wnr.0000000000001329
Abstract: Remifentanil is an ultra-short-acting µ-opioid receptor agonist, which is widely used in general anesthesia. However, comparing with other opioids, remifentanil often induces hyperalgesia. Accumulating evidence suggests that the transient receptor potential (TRP) channels and glial… read more here.
Keywords: activation; remifentanil; remifentanil induced; induced hyperalgesia ... See more keywords
2 Hz EA Reduces Heroin Withdrawal-Induced Hyperalgesia and Heroin Relapse by Downregulating P2X3 Receptors in DRG Neurons
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DOI: 10.1155/2019/1873859
Abstract: Electroacupuncture (EA) has effective analgesic effects. Our previous study demonstrated that the upregulation of P2X3 receptors in the dorsal root ganglia (DRG) might participate in heroin withdrawal-induced hyperalgesia. The aim of this study is to… read more here.
Keywords: p2x3 receptors; heroin; receptors drg; relapse ... See more keywords