Serotonin2B receptor blockade in the rat dorsal raphe nucleus suppresses cocaine-induced hyperlocomotion through an opposite control of mesocortical and mesoaccumbens dopamine pathways
Sign Up to like & getrecommendations! Published in 2020 at "Neuropharmacology"
DOI: 10.1016/j.neuropharm.2020.108309
Abstract: Serotonin2B receptor (5-HT2BR) antagonists inhibit cocaine-induced hyperlocomotion independently of changes of accumbal dopamine (DA) release. Given the tight relationship between accumbal DA activity and locomotion, and the inhibitory role of medial prefrontal cortex (mPFC) DA… read more here.
Keywords: induced hyperlocomotion; cocaine induced; serotonin2b receptor; dorsal raphe ... See more keywords
Metoprine, a histamine N-methyltransferase inhibitor, attenuates methamphetamine-induced hyperlocomotion via activation of histaminergic neurotransmission in mice
Sign Up to like & getrecommendations! Published in 2021 at "Pharmacology Biochemistry and Behavior"
DOI: 10.1016/j.pbb.2021.173257
Abstract: Metoprine increases the content of histamine in brain by inhibiting histamine N-methyltransferase (HMT), a centrally acting histamine degrading enzyme. We present data demonstrating that pretreatment with metoprine attenuates the hyperlocomotive effects of METH in mice… read more here.
Keywords: induced hyperlocomotion; metoprine; histamine; mice ... See more keywords
Hinokinin Decreases Methamphetamine-Induced Hyperlocomotion via the Regulatory Effects on Dopamine Levels.
Sign Up to like & getrecommendations! Published in 2025 at "ACS chemical neuroscience"
DOI: 10.1021/acschemneuro.4c00592
Abstract: The global abuse of stimulant methamphetamine (METH) imposes a significant social burden. Despite this, effective therapeutic interventions for mitigating the harmful effects associated with METH-induced central nervous system (CNS) stimulation remain elusive. Chamaecyparis obtusa (hinoki),… read more here.
Keywords: dopamine levels; induced hyperlocomotion; dopamine; hinokinin ... See more keywords