18F-FDG PET/CT for Detection of Immunotherapy-Induced Hypophysitis—A Case-Control Study
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DOI: 10.1097/rlu.0000000000005440
Abstract: Purpose Hypophysitis occurs in up to 10% of patients treated with immune-checkpoint inhibitors (ICIs). MRI shows no abnormalities of the pituitary gland in one third of patients. A delayed diagnosis increases the risk for life-threatening… read more here.
Keywords: detection; diagnosis; fdg pet; control ... See more keywords
Immune checkpoint inhibitor-induced hypophysitis: lessons learnt from a large cancer cohort
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DOI: 10.1136/jim-2021-002099
Abstract: Immune checkpoint inhibitors (ICIs) can cause pituitary dysfunction due to hypophysitis. We aimed to characterize ICI-induced hypophysitis and examine its association with overall survival in this single-center retrospective cohort study of adult patients with cancer… read more here.
Keywords: immune checkpoint; induced hypophysitis; cohort; hypophysitis ... See more keywords
Nivolumab induced hypophysitis in an advanced RCC patient
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DOI: 10.1177/10781552211072212
Abstract: Introduction Immune checkpoint inhibitors (ICIs) are being commonly used to treat solid tumours such as renal cell carcinoma. Hypophysitis is an acute or chronic inflammation of the pituitary gland and nivolumab or pembrolizumab induced hypophysitis… read more here.
Keywords: induced hypophysitis; patient; hypophysitis advanced; nivolumab induced ... See more keywords
Spectrum of Clinical Presentations, Imaging Findings, and HLA Types in Immune Checkpoint Inhibitor–Induced Hypophysitis
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DOI: 10.1210/jendso/bvad012
Abstract: Abstract Context Hypophysitis is a known immune-related adverse event (irAE) of immune checkpoint inhibitors (CPIs), commonly associated with CTLA-4 inhibitors and less often with PD-1/PD-L1 inhibitors. Objective We aimed to determine clinical, imaging, and HLA… read more here.
Keywords: immune checkpoint; induced hypophysitis; inhibitor; cpi hypophysitis ... See more keywords
6576 Nivolumab and Ipilimumab Induced Hypophysitis and Adrenal Crisis
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DOI: 10.1210/jendso/bvae163.1282
Abstract: Abstract Disclosure: R. Ripa: None. K. Kainth: None. D. Nasuti: None. C. Von Gizycki: None. Introduction: Over the years, immunotherapy has evolved to become the new standard of treatment due to its favorable clinic outcomes… read more here.
Keywords: none; immunotherapy; adrenal crisis; induced hypophysitis ... See more keywords
Two Cases of Atezolizumab-Induced Hypophysitis
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DOI: 10.1210/js.2017-00414
Abstract: Cancer immunotherapy has emerged as treatment of multiple advanced cancer types. Immune checkpoint inhibitors, namely anticytotoxic T-lymphocyte antigen-4 (CTLA-4), antiprogrammed cell death-1 (PD-1), and antiprogrammed cell death-1 ligand 1 (PD-L1) antibodies, have been used for… read more here.
Keywords: induced hypophysitis; treatment; hypophysitis; atezolizumab induced ... See more keywords
MRI Findings of Immune Checkpoint Inhibitor–Induced Hypophysitis: Possible Association with Fibrosis
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DOI: 10.3174/ajnr.a6692
Abstract: This retrospective international multicenter study comprised 20 patients with melanoma who were being treated with immune checkpoint inhibitors and clinically diagnosed with immune checkpoint inhibitor–induced hypophysitis. Three radiologists evaluated the following MR imaging findings: enlargement… read more here.
Keywords: checkpoint; inhibitor induced; checkpoint inhibitor; immune checkpoint ... See more keywords