Immune checkpoint inhibitor-induced hypophysitis: lessons learnt from a large cancer cohort
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Investigative Medicine"
DOI: 10.1136/jim-2021-002099
Abstract: Immune checkpoint inhibitors (ICIs) can cause pituitary dysfunction due to hypophysitis. We aimed to characterize ICI-induced hypophysitis and examine its association with overall survival in this single-center retrospective cohort study of adult patients with cancer… read more here.
Keywords: immune checkpoint; induced hypophysitis; cohort; hypophysitis ... See more keywords
Nivolumab induced hypophysitis in an advanced RCC patient
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Oncology Pharmacy Practice"
DOI: 10.1177/10781552211072212
Abstract: Introduction Immune checkpoint inhibitors (ICIs) are being commonly used to treat solid tumours such as renal cell carcinoma. Hypophysitis is an acute or chronic inflammation of the pituitary gland and nivolumab or pembrolizumab induced hypophysitis… read more here.
Keywords: induced hypophysitis; patient; hypophysitis advanced; nivolumab induced ... See more keywords
Spectrum of Clinical Presentations, Imaging Findings, and HLA Types in Immune Checkpoint Inhibitor–Induced Hypophysitis
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DOI: 10.1210/jendso/bvad012
Abstract: Abstract Context Hypophysitis is a known immune-related adverse event (irAE) of immune checkpoint inhibitors (CPIs), commonly associated with CTLA-4 inhibitors and less often with PD-1/PD-L1 inhibitors. Objective We aimed to determine clinical, imaging, and HLA… read more here.
Keywords: immune checkpoint; induced hypophysitis; inhibitor; cpi hypophysitis ... See more keywords
Two Cases of Atezolizumab-Induced Hypophysitis
Sign Up to like & getrecommendations! Published in 2018 at "Journal of the Endocrine Society"
DOI: 10.1210/js.2017-00414
Abstract: Cancer immunotherapy has emerged as treatment of multiple advanced cancer types. Immune checkpoint inhibitors, namely anticytotoxic T-lymphocyte antigen-4 (CTLA-4), antiprogrammed cell death-1 (PD-1), and antiprogrammed cell death-1 ligand 1 (PD-L1) antibodies, have been used for… read more here.
Keywords: induced hypophysitis; treatment; hypophysitis; atezolizumab induced ... See more keywords
MRI Findings of Immune Checkpoint Inhibitor–Induced Hypophysitis: Possible Association with Fibrosis
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DOI: 10.3174/ajnr.a6692
Abstract: This retrospective international multicenter study comprised 20 patients with melanoma who were being treated with immune checkpoint inhibitors and clinically diagnosed with immune checkpoint inhibitor–induced hypophysitis. Three radiologists evaluated the following MR imaging findings: enlargement… read more here.
Keywords: checkpoint; inhibitor induced; checkpoint inhibitor; immune checkpoint ... See more keywords