Facilitated AMPAR endocytosis causally contributes to the maternal sleep deprivation-induced impairments of synaptic plasticity and cognition in the offspring rats
Sign Up to like & getrecommendations! Published in 2018 at "Neuropharmacology"
DOI: 10.1016/j.neuropharm.2018.01.030
Abstract: ABSTRACT Maternal sleep deprivation (MSD) has been suggested to be associated with increased frequency of neurodevelopmental disorders in offspring in both humans and animal models. However, the underlying cellular and molecular mechanism is still unclear.… read more here.
Keywords: sleep deprivation; ampar endocytosis; offspring rats; maternal sleep ... See more keywords
Adenosine A2A receptor blockade prevents cisplatin-induced impairments in neurogenesis and cognitive function
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2206415119
Abstract: Chemotherapy-induced cognitive impairment (CICI) has emerged as a significant medical problem without therapeutic options. Using the platinum-based chemotherapy cisplatin to model CICI, we revealed robust elevations in the adenosine A2A receptor (A2AR) and its downstream… read more here.
Keywords: adenosine a2a; induced impairments; cisplatin induced; cisplatin ... See more keywords