Chronic Kidney Disease-Induced Insulin Resistance: Current State of the Field
Sign Up to like & getrecommendations! Published in 2018 at "Current Diabetes Reports"
DOI: 10.1007/s11892-018-1010-8
Abstract: Purpose of ReviewInsulin resistance is an early complication of chronic kidney disease (CKD) associated with worsening cardiovascular outcomes. This review will evaluate mechanisms responsible for CKD-induced insulin resistance and therapies currently available.Recent FindingsRecent mechanisms have… read more here.
Keywords: chronic kidney; resistance; ckd; insulin resistance ... See more keywords
Specific deletion of CDC42 in pancreatic β cells attenuates glucose-induced insulin expression and secretion in mice
Sign Up to like & getrecommendations! Published in 2020 at "Molecular and Cellular Endocrinology"
DOI: 10.1016/j.mce.2020.111004
Abstract: Insulin is a key hormone for maintaining glucose homeostasis in organisms. In general, deficiency of insulin synthesis and secretion results in type I diabetes, whereas insulin resistance leads to type 2 diabetes. Cell division cycle… read more here.
Keywords: insulin; secretion; pancreatic cells; insulin expression ... See more keywords
Depletion of regulator-of-G-protein signaling-10 in mice exaggerates high-fat diet-induced insulin resistance and inflammation, and this effect is mitigated by dietary green tea extract.
Sign Up to like & getrecommendations! Published in 2018 at "Nutrition research"
DOI: 10.1016/j.nutres.2018.06.004
Abstract: The interaction between insulin resistance and inflammation plays a central role in the development of chronic diseases, although the mechanism is not fully understood. We previously demonstrated that regulator of G-protein signaling-10 (RGS10) protein is… read more here.
Keywords: resistance inflammation; high fat; resistance; insulin resistance ... See more keywords
Serious diabetic ketoacidosis induced by insulin allergy and anti‐insulin antibody in an individual with type 2 diabetes mellitus
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Diabetes Investigation"
DOI: 10.1111/jdi.13838
Abstract: Diabetic ketoacidosis (DKA) is one of the most serious acute metabolic complications of diabetes mellitus, and is characterized by hyperglycemia, metabolic acidosis and increased total ketone body concentrations. The main mechanism of DKA is a… read more here.
Keywords: allergy anti; insulin; insulin allergy; anti insulin ... See more keywords
PI3K Inhibitor-Induced Insulin Feedback Activates PI3K Signaling.
Sign Up to like & getrecommendations! Published in 2018 at "Cancer discovery"
DOI: 10.1158/2159-8290.cd-rw2018-116
Abstract: Hyperinsulinemia drives resistance to PI3Kα inhibitors in tumors. read more here.
Keywords: inhibitor induced; insulin feedback; feedback activates; activates pi3k ... See more keywords
Effects of Pregnancy-Induced Insulin Resistance on the Fetus and the Future Development of Metabolic Diseases in Adulthood.
Sign Up to like & getrecommendations! Published in 2019 at "Current vascular pharmacology"
DOI: 10.2174/1570161117999190823154608
Abstract: read more here.
Keywords: effects pregnancy; pregnancy induced; fetus future; resistance fetus ... See more keywords
Targeting IRE1α and PERK in the endoplasmic reticulum stress pathway attenuates fatty acid-induced insulin resistance in bovine hepatocytes.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of dairy science"
DOI: 10.3168/jds.2021-21754
Abstract: Endoplasmic reticulum (ER) stress can be induced by various stimuli and triggers the unfolded protein response to activate intracellular signaling pathways that are mediated by 3 ER-resident sensors: inositol requiring protein-1α (IRE1α), PKR-like ER kinase… read more here.
Keywords: stress; insulin resistance; perk; resistance ... See more keywords
Tripeptide IRW Improves AMPK/eNOS Signaling Pathway via Activating ACE2 in the Aorta of High-Fat-Diet-Fed C57BL/6 Mice
Sign Up to like & getrecommendations! Published in 2023 at "Biology"
DOI: 10.3390/biology12040556
Abstract: Simple Summary Metabolic syndrome refers to a cluster of various risk factors commonly associated with cardiovascular diseases and diabetes. Upregulation of angiotensin-converting enzyme 2 (ACE2), a key member of the renin–angiotensin system (RAS), is in… read more here.
Keywords: insulin resistant; hfd induced; high fat; mice ... See more keywords