USP15 attenuates IGF-I signaling by antagonizing Nedd4-induced IRS-2 ubiquitination.
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DOI: 10.1016/j.bbrc.2017.01.101
Abstract: Insulin receptor substrates (IRSs) are phosphorylated by IGF-I receptor tyrosine kinase in a ligand-dependent manner. In turn, they bind to and activate effector proteins such as PI3K, leading to various cell responses including cell proliferation.… read more here.
Keywords: igf signaling; irs ubiquitination; usp15 attenuates; induced irs ... See more keywords