Nppb Neurons Are Sensors of Mast Cell-Induced Itch
Sign Up to like & getrecommendations! Published in 2019 at "Cell reports"
DOI: 10.1016/j.celrep.2019.02.089
Abstract: SUMMARY Itch is an unpleasant skin sensation that can be triggered by exposure to many chemicals, including those released by mast cells. The natriuretic polypep-tide b (Nppb)-expressing class of sensory neurons, when activated, elicits scratching… read more here.
Keywords: itch; cell induced; nppb neurons; induced itch ... See more keywords
Itch induced by peripheral mu opioid receptors is dependent on TRPV1-expressing neurons and alleviated by channel activation
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-33620-7
Abstract: Opioids remain the gold standard for the treatment of moderate to severe pain. However, their analgesic properties come with important side effects, including pruritus, which occurs frequently after systemic or neuraxial administration. Although part of… read more here.
Keywords: trpv1; itch; induced itch; trpv1 expressing ... See more keywords
Development of resistance to serotonin‐induced itch in bile duct ligated mice
Sign Up to like & getrecommendations! Published in 2017 at "Clinical and Experimental Pharmacology and Physiology"
DOI: 10.1111/1440-1681.12752
Abstract: Cholestatic itch can be severe and significantly impair the quality of life of patients. The serotonin system is implicated in cholestatic itch; however, the pruritogenic properties of serotonin have not been evaluated in cholestatic mice.… read more here.
Keywords: itch; serotonin induced; induced itch; bile duct ... See more keywords
Inhibition of M/Kv7 Currents Contributes to Chloroquine-Induced Itch in Mice
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Molecular Neuroscience"
DOI: 10.3389/fnmol.2020.00105
Abstract: M/Kv7 potassium channels play a key role in regulation of neuronal excitability. Modulation of neuronal excitability of primary sensory neurons determines the itch sensation induced by a variety of itch-causing substances including chloroquine (CQ). In… read more here.
Keywords: itch; neuronal excitability; itch mice; induced itch ... See more keywords
TRPV1 and TRPA1 Channels Are Both Involved Downstream of Histamine-Induced Itch
Sign Up to like & getrecommendations! Published in 2021 at "Biomolecules"
DOI: 10.3390/biom11081166
Abstract: Two histamine receptor subtypes (HR), namely H1R and H4R, are involved in the transmission of histamine-induced itch as key components. Although exact downstream signaling mechanisms are still elusive, transient receptor potential (TRP) ion channels play… read more here.
Keywords: induced itch; histamine induced; trpv1 trpa1;
Berbamine Reduces Chloroquine-Induced Itch in Mice through Inhibition of MrgprX1
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms232214321
Abstract: Chloroquine (CQ) is an antimalaria drug that has been widely used for decades. However, CQ-induced pruritus remains one of the major obstacles in CQ treatment for uncomplicated malaria. Recent studies have revealed that MrgprX1 plays… read more here.
Keywords: induced pruritus; induced itch; mrgprx1; berbamine ... See more keywords