Ginsenoside Rg3 attenuates cisplatin-induced kidney injury through inhibition of apoptosis and autophagy-inhibited NLRP3.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of biochemical and molecular toxicology"
DOI: 10.1002/jbt.22896
Abstract: The NOD-like receptor family pyrin domain-containing (NLRP3) inflammasomes is centrally implicated in cisplatin (CP)-induced kidney injury. Autophagy is critical for inhibiting production of NLRP3 protein that effectively reduces the inflammatory response. Ginsenoside Rg3 (SY), an… read more here.
Keywords: kidney injury; induced kidney; inhibition; cisplatin induced ... See more keywords
Oral administration of powdered dried rhizomes of Curcuma longa L. (turmeric, Zingiberaceae) is effective in the treatment of doxorubicin‐induced kidney injury in rats
Sign Up to like & getrecommendations! Published in 2018 at "Phytotherapy Research"
DOI: 10.1002/ptr.6176
Abstract: Curcumin is a polyphenol present in the rhizomes of the species Curcuma longa L. (“turmeric,” Zingiberaceae), which has been used for centuries as an anti‐inflammatory. We aimed to evaluate the anti‐inflammatory effects of C. longa… read more here.
Keywords: kidney injury; longa turmeric; induced kidney; curcuma longa ... See more keywords
Tyrosine kinase nonreceptor 1 (TNK1) knockdown ameliorates hemorrhage shock-induced kidney injury via inhibiting macrophage M1 polarization
Sign Up to like & getrecommendations! Published in 2021 at "3 Biotech"
DOI: 10.1007/s13205-021-03042-w
Abstract: Hemorrhage shock (HS) is a major threat to patients with trauma and spontaneous bleeding, resulting in multi-organ failure including the kidney. Tyrosine kinase nonreceptor 1 (TNK1) has been shown to be upregulated in the kidney… read more here.
Keywords: tnk1 knockdown; macrophage polarization; kidney injury; induced kidney ... See more keywords
Continentalic acid exhibited nephroprotective activity against the LPS and E. coli-induced kidney injury through inhibition of the oxidative stress and inflammation.
Sign Up to like & getrecommendations! Published in 2020 at "International immunopharmacology"
DOI: 10.1016/j.intimp.2020.106209
Abstract: The present study investigated the effect of the continentalic acid (CNT) isolated from the Aralia Continentalis against the LPS and E. coli-induced nephrotoxicity. The LPS and E. coli administration markedly altered the behavioral parameters including… read more here.
Keywords: kidney injury; induced kidney; lps coli; cnt treatment ... See more keywords
Rhizoma smilacis glabrae protects rats with gentamicin-induced kidney injury from oxidative stress-induced apoptosis by inhibiting caspase-3 activation.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of ethnopharmacology"
DOI: 10.1016/j.jep.2016.12.034
Abstract: ETHNOPHARMACOLOGICAL RELEVANCE Rhizoma smilacis glabrae (RSG), which is mild-natured and tastes sweet or bland, has pharmacological action of eliminating dampness, detoxifying, and ensuring that joints were healthy and supple in traditional Chinese medicine. AIM OF… read more here.
Keywords: kidney injury; induced kidney; apoptosis; injury ... See more keywords
The mTOR inhibitor everolimus attenuates tacrolimus-induced renal interstitial fibrosis in rats.
Sign Up to like & getrecommendations! Published in 2021 at "Life sciences"
DOI: 10.1016/j.lfs.2021.120150
Abstract: AIMS Tacrolimus-a widely used immunosuppressant to prevent allograft rejection after organ transplantation-is nephrotoxic, increasing the risk of kidney injury accompanied by kidney fibrosis. The mammalian target of rapamycin (mTOR) inhibitor, everolimus, is an immunosuppressant used… read more here.
Keywords: everolimus; fibrosis; induced kidney; kidney fibrosis ... See more keywords
Toxicodynamics of Lead, Cadmium, Mercury and Arsenic- induced kidney toxicity and treatment strategy: A mini review
Sign Up to like & getrecommendations! Published in 2018 at "Toxicology Reports"
DOI: 10.1016/j.toxrep.2018.05.012
Abstract: Highlights • Oxidative Stress is the key mechanism involved in Lead, Mercury, Cadmium and Arsenic-induced kidney toxicity.• Proteinuria is common to all heavy metals as manifestation of kidney damage.• Chelation therapy is recommended based on… read more here.
Keywords: arsenic induced; induced kidney; mercury; kidney toxicity ... See more keywords
A Multiplatform Approach for the Discovery of Novel Drug-Induced Kidney Injury Biomarkers.
Sign Up to like & getrecommendations! Published in 2017 at "Chemical research in toxicology"
DOI: 10.1021/acs.chemrestox.7b00159
Abstract: Drug-induced kidney injury (DIKI) is a common toxicity observed in pharmaceutical development. We demonstrated the use of label-free liquid chromatography-mass spectrometry (LC-MS) and multiplex liquid chromatography-single reaction monitoring (LC-SRM) as practical extensions of standard immunoassay… read more here.
Keywords: kidney injury; induced kidney; drug induced; discovery ... See more keywords
Histomorphological and ultrastructural cadmium-induced kidney injuries and precancerous lesions in rats and screening for biomarkers
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DOI: 10.1042/bsr20212516
Abstract: Abstract Long-term exposure to cadmium (Cd) can severely damage the kidney, where orally absorbed Cd accumulates. However, the molecular mechanisms of Cd-induced kidney damage, especially the early biomarkers of Cd-induced renal carcinogenesis, are unclear. In… read more here.
Keywords: induced kidney; cadmium; kidney; kidney injury ... See more keywords
Eucalyptol alleviates cisplatin-induced kidney damage in rats.
Sign Up to like & getrecommendations! Published in 2022 at "Drug and chemical toxicology"
DOI: 10.1080/01480545.2022.2156530
Abstract: This study was aimed to explore the therapeutic effect of eucalyptol on cisplatin induced kidney damage in Wistar albino rats. The animals were divided into four groups: sham (S), eucalyptol (E), cisplatin (C), and cisplatin + eucalyptol… read more here.
Keywords: induced kidney; kidney damage; group; cisplatin induced ... See more keywords
Prediction of drug-induced kidney injury in drug discovery
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DOI: 10.1080/03602532.2021.1922436
Abstract: Abstract Drug induced kidney injury is one of the leading causes of failure of drug development programs in the clinic. Early prediction of renal toxicity potential of drugs is crucial to the success of drug… read more here.
Keywords: kidney injury; induced kidney; drug induced; drug ... See more keywords