Hierarchy‐Assembled Dual Probiotics System Ameliorates Cholestatic Drug‐Induced Liver Injury via Gut‐Liver Axis Modulation
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Science"
DOI: 10.1002/advs.202200986
Abstract: Cholestatic drug‐induced liver injury (DILI) induced by drugs or other xenobiotics is a severe and even fatal clinical syndrome. Here, living materials of hierarchy‐assembled dual probiotics system are fabricated by sequentially encapsulating probiotic Lactobacillus delbrueckii… read more here.
Keywords: drug induced; gut; dili; cholestatic drug ... See more keywords
A literature review for the mechanisms of stress‐induced liver injury
Sign Up to like & getrecommendations! Published in 2019 at "Brain and Behavior"
DOI: 10.1002/brb3.1235
Abstract: Experimental studies and clinical observations have shown that stress can damage hepatic tissue both directly and indirectly. Many studies have partially revealed the contributors of stress‐induced liver injury; however, the whole process has not yet… read more here.
Keywords: induced liver; stress induced; liver injury; literature review ... See more keywords
Lymphocyte profile and immune checkpoint expression in drug-induced liver injury: an immunophenotyping study.
Sign Up to like & getrecommendations! Published in 2021 at "Clinical pharmacology and therapeutics"
DOI: 10.1002/cpt.2423
Abstract: The identification of specific human leukocyte antigen (HLA) risk alleles in drug-induced liver injury (DILI) points towards an important role of the adaptive immune system in DILI development. In this study we aimed to corroborate… read more here.
Keywords: immune checkpoint; induced liver; drug induced; liver injury ... See more keywords
Prediction of Biochemical Nonresolution in Patients with Chronic Drug-induced Liver Injury: A Large Multicenter Study.
Sign Up to like & getrecommendations! Published in 2021 at "Hepatology"
DOI: 10.1002/hep.32283
Abstract: BACKGROUND AND AIMS To clarify high-risk factors and develop a novel nomogram model to predict biochemical resolution (BR) or not (BNR) in patients with chronic drug-induced liver injury (DILI). APPROACH AND RESULTS Retrospectively, 3,655 out… read more here.
Keywords: chronic drug; biochemical nonresolution; liver injury; patients chronic ... See more keywords
Exogenous recombinant human thioredoxin‐1 prevents acetaminophen‐induced liver injury by scavenging oxidative stressors, restoring the thioredoxin‐1 system and inhibiting receptor interacting protein‐3 overexpression
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Applied Toxicology"
DOI: 10.1002/jat.3609
Abstract: Thioredoxin‐1 (Trx‐1) is a potent therapeutic agent against a variety of diseases because of its actions as an antioxidant and regulator of apoptosis. N‐acetyl‐p‐aminophenol (APAP), commonly known as acetaminophen, generates excessive oxidative stress and triggers… read more here.
Keywords: overexpression; induced liver; thioredoxin; trx ... See more keywords
Prediction of clinically relevant drug‐induced liver injury from structure using machine learning
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Applied Toxicology"
DOI: 10.1002/jat.3741
Abstract: Drug‐induced liver injury (DILI) is the most common cause of acute liver failure and often responsible for drug withdrawals from the market. Clinical manifestations vary, and toxicity may or may not appear dose‐dependent. We present… read more here.
Keywords: machine learning; liver injury; prediction clinically; drug induced ... See more keywords
Evidence for exposure biomarkers in dictamnine‐induced liver injury resulting from metabolic activation in vitro and in mice
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Applied Toxicology"
DOI: 10.1002/jat.4414
Abstract: Dictamnine (DTN), a furoquinoline alkaloid isolated from Dictamni Cortex, is responsible for the liver injury caused by Dictamni Cortex and the preparations. Discovering new biomarkers with high specificity and sensitivity for diagnosis and tracing the… read more here.
Keywords: induced liver; liver injury; exposure biomarkers; dtn ... See more keywords
Dimethyl fumarate protects thioacetamide‐induced liver damage in rats: Studies on Nrf2, NLRP3, and NF‐κB
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Biochemical and Molecular Toxicology"
DOI: 10.1002/jbt.22476
Abstract: The present study was designed to investigate the hepatoprotective potential of dimethyl fumarate (DMF) against thioacetamide (TAA)‐induced liver damage. Wistar rats were treated with DMF (12.5, 25, and 50 mg/kg/day, orally) and TAA (200 mg/kg intraperitoneally, every… read more here.
Keywords: induced liver; liver damage; taa induced; dimethyl fumarate ... See more keywords
Protective effect of hypoglycemic granule against diabetes‐induced liver injury by alleviating glycolipid metabolic disorder and oxidative stress
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.29588
Abstract: The current study was designed to explore the therapeutic effect and mechanism of different extraction, which came from hypoglycemic granule on diabetes‐induced liver injury. The ethanol fraction (HGEF) and aqueous fraction (HGAF) from hypoglycemic granule… read more here.
Keywords: hypoglycemic granule; liver injury; induced liver; granule diabetes ... See more keywords
MFGE8 protects against CCl4‐induced liver injury by reducing apoptosis and promoting proliferation of hepatocytes
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.28314
Abstract: Milk fat globule‐EGF factor 8 (MFGE8) has been reported to play various roles in acute injury and inflammation response. However, the role of MFGE8 in liver injury is poorly investigated. The present research was designed… read more here.
Keywords: induced liver; expression; mfge8; ccl4 induced ... See more keywords
Drug‐Induced Liver Injury After Liver Transplantation
Sign Up to like & getrecommendations! Published in 2020 at "Liver Transplantation"
DOI: 10.1002/lt.25804
Abstract: Drug‐induced liver injury (DILI) is an adverse reaction to many drugs in common use that in a liver transplantation (LT) recipient may cause graft dysfunction and may even lead to graft loss and the need… read more here.
Keywords: liver injury; liver transplantation; induced liver; drug induced ... See more keywords