Loss of genomic integrity induced by lysosphingolipid imbalance drives ageing in the heart
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DOI: 10.15252/embr.201847407
Abstract: Cardiac dysfunctions dramatically increase with age. Revealing a currently unknown contributor to cardiac ageing, we report the age‐dependent, cardiac‐specific accumulation of the lysosphingolipid sphinganine (dihydrosphingosine, DHS) as an evolutionarily conserved hallmark of the aged vertebrate… read more here.
Keywords: loss genomic; heart; integrity induced; induced lysosphingolipid ... See more keywords