m6A-Methylated Taurine Transporter SLC6A6 Promotes Arsenic-Induced Malignant Transformation of Keratinocytes while Enhancing Sensitivity to Cuproptosis.
Sign Up to like & getrecommendations! Published in 2025 at "Environmental science & technology"
DOI: 10.1021/acs.est.5c01604
Abstract: Despite extensive studies on arsenic's carcinogenic effects, the epigenetic mechanisms underlying arsenic-induced malignant transformation at the metabolic level remain poorly understood. In this study, we explored epitranscriptomic-driven metabolic reprogramming using keratinocyte transformation models established by… read more here.
Keywords: induced malignant; slc6a6; arsenic induced; malignant transformation ... See more keywords
Ursolic and oleanolic acids suppress MNNG induced malignant transformation of human gastric mucosal epithelium by regulating the PI3 K/AKT pathway
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DOI: 10.1038/s41598-025-03606-3
Abstract: Berberine hydrochloride (Ber) is the primary active compound in the traditional Chinese medicine ‘Huanglian’. Ursolic acid (UA) and oleanolic acid (OA) are the main triterpenoids extracted from ‘Tengligen’. Notably, both Ber and UA/OA exhibit antitumour… read more here.
Keywords: induced malignant; malignant transformation; mnng induced; pathway ... See more keywords
Epstein-Barr Virus Keratouveitis-Induced Malignant Glaucoma After Penetrating Keratoplasty: A Case Report and Literature Review.
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DOI: 10.1080/09273948.2023.2208659
Abstract: PURPOSE To report a case of Epstein-Barr virus (EBV) keratouveitis-induced malignant glaucoma after repeat penetrating keratoplasty (PK). METHODS Retrospective review of the patient's medical records and review of literature on EBV corneal endotheliitis and/or anterior… read more here.
Keywords: glaucoma; review; epstein barr; malignant glaucoma ... See more keywords
Identification of Candidate lncRNA and Pseudogene Biomarkers Associated with Carbon-Nanotube-Induced Malignant Transformation of Lung Cells and Prediction of Potential Preventive Drugs
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DOI: 10.3390/ijerph19052936
Abstract: Mounting evidence has linked carbon nanotube (CNT) exposure with malignant transformation of lungs. Long non-coding RNAs (lncRNAs) and pseudogenes are important regulators to mediate the pathogenesis of diseases, representing potential biomarkers for surveillance of lung… read more here.
Keywords: carbon nanotube; preventive drugs; lung; malignant transformation ... See more keywords
Aryl Hydrocarbon Receptor (AHR) Suppresses Arsenic (As3+)-Induced Malignant Transformation by Antagonizing TOX Expression
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DOI: 10.7150/ijbs.107268
Abstract: Environmental arsenic (As³⁺) exposure poses a significant public health concern due to its carcinogenic potential. Our previous research suggests that As³⁺-induced carcinogenesis is mediated by inhibition of the aryl hydrocarbon receptor (AHR). However, the precise… read more here.
Keywords: induced malignant; receptor ahr; malignant transformation; hydrocarbon receptor ... See more keywords