Bone marrow‐derived mesenchymal stem cells alleviate paclitaxel‐induced mechanical allodynia in rats
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Biochemical and Molecular Toxicology"
DOI: 10.1002/jbt.23207
Abstract: Anticancer drug paclitaxel (PTX) frequently causes painful peripheral neuropathy; however, no medication has been shown to be effective in the treatment of this debilitating side effect. We aimed to investigate the efficacy of two different… read more here.
Keywords: ptx; induced mechanical; bone marrow; allodynia ... See more keywords
TAFA4 relieves injury-induced mechanical hypersensitivity through LDL receptors and modulation of spinal A-type K+ current.
Sign Up to like & getrecommendations! Published in 2021 at "Cell reports"
DOI: 10.1016/j.celrep.2021.109884
Abstract: Pain, whether acute or persistent, is a serious medical problem worldwide. However, its management remains unsatisfactory, and new analgesic molecules are required. We show here that TAFA4 reverses inflammatory, postoperative, and spared nerve injury (SNI)-induced… read more here.
Keywords: induced mechanical; mechanical hypersensitivity; tafa4; type current ... See more keywords
A new concept of the mechanism of tribocatalytic reactions induced by mechanical forces
Sign Up to like & getrecommendations! Published in 2017 at "Tribology International"
DOI: 10.1016/j.triboint.2016.08.022
Abstract: Abstract The aim of this paper is to present a new approach to the mechanism of tribocatalytic reactions induced by mechanical forces. The new concept is based on the authors’ previous research, which reveals that… read more here.
Keywords: reactions induced; induced mechanical; tribocatalytic reactions; mechanical forces ... See more keywords
Touch-induced mechanical strain in somatosensory neurons is independent of extracellular matrix mutations in Caenorhabditis elegans
Sign Up to like & getrecommendations! Published in 2020 at "Molecular Biology of the Cell"
DOI: 10.1091/mbc.e20-01-0049
Abstract: Cutaneous mechanosensory neurons are activated by mechanical loads applied to the skin, and these stimuli are proposed to generate mechanical strain within sensory neurons. Using a microfluidic device to deliver controlled stimuli to intact animals… read more here.
Keywords: touch induced; mechanical strain; induced mechanical; caenorhabditis elegans ... See more keywords
Chemokine CCL2 and its receptor CCR2 in the dorsal root ganglion contribute to oxaliplatin-induced mechanical hypersensitivity
Sign Up to like & getrecommendations! Published in 2018 at "PAIN"
DOI: 10.1097/j.pain.0000000000001212
Abstract: Abstract Activation of innate immune mechanisms within the dorsal root ganglion and spinal dorsal horn has been shown to play a key role in the development of neuropathic pain including paclitaxel-related chemotherapy-induced peripheral neuropathy (CIPN).… read more here.
Keywords: oxaliplatin induced; induced mechanical; root ganglion; ccl2 ... See more keywords
Cell-specific role of HDAC6 in chemotherapy-induced mechanical allodynia and loss of intraepidermal nerve fibers.
Sign Up to like & getrecommendations! Published in 2019 at "Pain"
DOI: 10.1097/j.pain.0000000000001667
Abstract: Chemotherapy-induced peripheral neuropathy (CIPN) is a serious adverse side effect of cancer treatment with no FDA-approved medication for its prevention or management. Using RNA sequencing analysis of dorsal root ganglia (DRG) we identify critical contributions… read more here.
Keywords: induced mechanical; cisplatin induced; allodynia; mechanical allodynia ... See more keywords
Pressure-induced mechanical instabilities in cubic SiC: Structural and electronic properties
Sign Up to like & getrecommendations! Published in 2025 at "Physical Review B"
DOI: 10.1103/5h2n-mw9m
Abstract: Silicon carbide is widely used in electronics, ceramics, and renewable energy due to its exceptional hardness and resistance. In this study, we investigate the effects of hydrostatic and uniaxial pressure (both compressive and tensile) on… read more here.
Keywords: pressure; structural electronic; electronic properties; pressure induced ... See more keywords
Increased keratinocyte activity and PIEZO1 signaling contribute to paclitaxel-induced mechanical hypersensitivity.
Sign Up to like & getrecommendations! Published in 2024 at "Science translational medicine"
DOI: 10.1126/scitranslmed.adn5629
Abstract: Recent work demonstrates that epidermal keratinocytes are critical for normal touch sensation. However, it is unknown whether keratinocytes contribute to touch-evoked pain and hypersensitivity after tissue injury. Here, we used a mouse model of paclitaxel… read more here.
Keywords: paclitaxel; paclitaxel induced; induced mechanical; keratinocyte activity ... See more keywords
Sympathectomy Ameliorates CFA-Induced Mechanical Allodynia via Modulating Phenotype of Macrophages in Sensory Ganglion in Mice
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Inflammation Research"
DOI: 10.2147/jir.s388322
Abstract: Background The sympathetic nervous system (SNS) is suggested to be involved in some forms of pain, but the mechanisms of which are incompletely known. Moreover, there is a lack of information on the regulatory role… read more here.
Keywords: macrophages sensory; ganglion; induced mechanical; cfa induced ... See more keywords
Repeated Valproic Acid Administration Fundamentally Ameliorated Cisplatin-Induced Mechanical Allodynia in Rats
Sign Up to like & getrecommendations! Published in 2025 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms26114977
Abstract: Cisplatin (cis-diamminedichloro-platinum; CDDP) is a chemotherapeutic agent that frequently induces peripheral neuropathy characterized by mechanical allodynia. Herein, we aimed to determine the effects of valproic acid (VPA) on cisplatin-induced mechanical allodynia in rats and elucidate… read more here.
Keywords: cddp induced; mechanical allodynia; induced mechanical; administration ... See more keywords