Metformin attenuates antipsychotic-induced metabolic dysfunctions in MK801-induced schizophrenia-like rats
Sign Up to like & getrecommendations! Published in 2020 at "Psychopharmacology"
DOI: 10.1007/s00213-020-05524-w
Abstract: Rationale Second-generation antipsychotics are the first-line medications prescribed for schizophrenic patients; however, some of them, such as olanzapine and risperidone, may induce metabolic dysfunctions during short-term treatment. Metformin is an effective adjuvant that attenuates antipsychotic-induced… read more here.
Keywords: schizophrenia like; mk801 induced; olanzapine risperidone; metabolic dysfunctions ... See more keywords
Risperidone-induced metabolic dysfunction is attenuated by Curcuma longa extract administration in mice
Sign Up to like & getrecommendations! Published in 2017 at "Metabolic Brain Disease"
DOI: 10.1007/s11011-017-0133-y
Abstract: Antipsychotics, such as risperidone, increase food intake and induce alteration in glucose and lipid metabolism concomitantly with overweight and body fat increase, these biological abnormalities belong to the metabolic syndrome definition (high visceral adiposity, hypertriglyceridemia,… read more here.
Keywords: curcuma longa; longa extract; risperidone induced; risperidone ... See more keywords
Exercise Alleviates Obesity-Induced Metabolic Dysfunction via Enhancing FGF21 Sensitivity in Adipose Tissues.
Sign Up to like & getrecommendations! Published in 2019 at "Cell reports"
DOI: 10.1016/j.celrep.2019.02.014
Abstract: Exercise promotes adipose remodeling and improves obesity-induced metabolic disorders through mechanisms that remain obscure. Here, we identify the FGF21 signaling in adipose tissues as an obligatory molecular transducer of exercise conferring its metabolic benefits in… read more here.
Keywords: induced metabolic; exercise alleviates; adipose tissues; obesity induced ... See more keywords
In vitro antioxidant activity, α-glucosidase inhibitory potential and in vivo protective effect of Asparagus stipularis Forssk aqueous extract against high-fructose diet-induced metabolic syndrome in rats
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Functional Foods"
DOI: 10.1016/j.jff.2018.06.006
Abstract: Abstract The study was carried out to evaluate the in vitro antioxidant, α-glucosidase inhibitory potential and the protective effect of Asparagus stipularis Forssk aqueous extract against high-fructose diet (HFD; 10% fructose solution for 5 months) induced… read more here.
Keywords: syndrome rats; protective effect; vitro antioxidant; metabolic syndrome ... See more keywords
Neonatal zingerone protects against the development of high-fructose diet-induced metabolic syndrome in adult Sprague-Dawley rats
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Developmental Origins of Health and Disease"
DOI: 10.1017/s2040174420000525
Abstract: Abstract During the early postnatal period, dietary manipulations can alter the developmental trajectory of the growing offspring, causing beneficial or adverse health outcomes later in adult life. We investigated the potential preventive effects of neonatal… read more here.
Keywords: bwt; high fructose; induced metabolic; neonatal zingerone ... See more keywords
Red Wine High-Molecular-Weight Polyphenolic Complex Ameliorates High-Fat Diet-Induced Metabolic Dysregulation and Perturbation in Gut Microbiota in Mice.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.2c06459
Abstract: Red wine polyphenolic complexes have attracted increasing attention as potential modulators of human metabolic disease risk. Our previous study discovered that red wine high-molecular-weight polymeric polyphenolic complexes (HPPCs) could inhibit key metabolic syndrome-associated enzymes and… read more here.
Keywords: red wine; polyphenolic; metabolic dysregulation; induced metabolic ... See more keywords
Effects of α-Galactooligosaccharides from Chickpeas on High-Fat-Diet-Induced Metabolic Syndrome in Mice.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.7b00489
Abstract: The gut microbiota has the ability to modulate host energy homeostasis, which may regulate metabolic disorders. Functional oligosaccharide may positively regulate the intestinal microbiota. Therefore, effects of α-galactooligosaccharides (α-GOS) from chickpea on high-fat-diet (HFD)-induced metabolic… read more here.
Keywords: fat diet; high fat; effects galactooligosaccharides; metabolic syndrome ... See more keywords
Development of Novel IP6K Inhibitors for the Treatment of Obesity and Obesity-Induced Metabolic Dysfunctions.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.2c00220
Abstract: Obesity and obesity-induced metabolic dysfunctions are significant risk factors for nonalcoholic fatty liver disease and cardiovascular diseases. Thus, obesity is an economic and social burden in developed countries. Blocking the synthesis of inositol pyrophosphates by… read more here.
Keywords: obesity; obesity induced; obesity obesity; metabolic dysfunctions ... See more keywords
An Unexpected Deuterium-Induced Metabolic Switch in Doxophylline
Sign Up to like & getrecommendations! Published in 2022 at "ACS Medicinal Chemistry Letters"
DOI: 10.1021/acsmedchemlett.2c00166
Abstract: Precision deuteration has become part of the medicinal chemist’s toolbox, but its usefulness can be undermined by unpredictable metabolic switch effects. Herein we report the deuteration of doxophylline, a drug used in the treatment of… read more here.
Keywords: unexpected deuterium; metabolic switch; switch; switch doxophylline ... See more keywords
PUFA-induced metabolic enteritis as a fuel for Crohn's disease.
Sign Up to like & getrecommendations! Published in 2022 at "Gastroenterology"
DOI: 10.1053/j.gastro.2022.01.004
Abstract: BACKGROUND & AIMS Crohn's disease (CD) globally emerges with Westernization of lifestyle and nutritional habits. However, a specific dietary constituent that comprehensively evokes gut inflammation in human IBD remains elusive. Here, we aimed at delineating… read more here.
Keywords: disease; crohn disease; pufa; pufa induced ... See more keywords
Dietary phenolic acids reverse insulin resistance, hyperglycaemia, dyslipidaemia, inflammation and oxidative stress in high-fructose diet-induced metabolic syndrome rats
Sign Up to like & getrecommendations! Published in 2018 at "Archives of Physiology and Biochemistry"
DOI: 10.1080/13813455.2017.1415938
Abstract: Abstract This study investigated the influence of caffeic, ferulic, gallic and protocatechuic acids on high-fructose diet-induced metabolic syndrome in rats. Oral administration of the phenolic acids significantly reversed high-fructose diet-mediated increase in body mass index… read more here.
Keywords: diet induced; phenolic acids; fructose diet; high fructose ... See more keywords