Amentoflavone Ameliorates Memory Deficits and Abnormal Autophagy in Aβ25-35-Induced Mice by mTOR Signaling.
Sign Up to like & getrecommendations! Published in 2021 at "Neurochemical research"
DOI: 10.1007/s11064-020-03223-8
Abstract: Alzheimer's disease (AD) is a neurodegenerative disease in which autophagy plays a crucial role. Amentoflavone is a flavonoid obtained from various plants and has been shown to have AD-resistant neuroprotective effects. This study investigated the… read more here.
Keywords: amentoflavone; induced mice; mtor; autophagy ... See more keywords
Elevated Plasma Levels of LDL Cholesterol Promote Dissecting Thoracic Aortic Aneurysms in Angiotensin II-Induced Mice.
Sign Up to like & getrecommendations! Published in 2018 at "Annals of vascular surgery"
DOI: 10.1016/j.avsg.2017.10.006
Abstract: BACKGROUND Plasma low-density lipoprotein (LDL) cholesterol is implicated in abdominal aorta (AA) and aortic dissection (AD); however, its role in the pathogenesis of AA and AD, a disease with a high mortality rate, is unknown.… read more here.
Keywords: ldl cholesterol; cholesterol; formation; induced mice ... See more keywords
Cornuside ameliorates cognitive impairments in scopolamine induced AD mice: Involvement of neurotransmitter and oxidative stress.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of ethnopharmacology"
DOI: 10.1016/j.jep.2022.115252
Abstract: ETHNOPHARMACOLOGICAL RELEVANCE Cornus officinalis Sieb. et Zucc., traditional Chinese medicine, has been widely used in the treatment of dementia. Cornel iridoid glycosides of Cornus officinalis is therapeutic to Alzheimer's disease (AD), while its pharmacodynamic material… read more here.
Keywords: test; induced mice; scopolamine induced; oxidative stress ... See more keywords
DHA enriched phospholipids with different polar groups (PC and PS) had different improvements on MPTP-induced mice with Parkinson’s disease
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Functional Foods"
DOI: 10.1016/j.jff.2018.04.017
Abstract: Abstract Docosahexaenoic acid (DHA) enriched phospholipids such as phosphatidylcholine (PC) and phosphatidylserine (PS) are important bioactive components and widely distributed in multifarious marine products. In the present study, we investigated the effects of DHA enriched… read more here.
Keywords: dha enriched; phospholipids different; mptp induced; enriched phospholipids ... See more keywords
Maresin 1 alleviates the inflammatory response, reduces oxidative stress and protects against cardiac injury in LPS-induced mice.
Sign Up to like & getrecommendations! Published in 2021 at "Life sciences"
DOI: 10.1016/j.lfs.2021.119467
Abstract: BACKGROUND Maresin 1 (MaR1) is a pro-resolving lipid mediator that has been reported to have strong regulatory effects on oxidative stress and inflammation. This study aimed to determine the effect of MaR1 on lipopolysaccharide (LPS)-induced… read more here.
Keywords: oxidative stress; induced mice; lps induced; cardiac injury ... See more keywords
CY-09 Alleviates the Depression-like Behaviors via Inhibiting NLRP3 Inflammasome-Mediated Neuroinflammation in Lipopolysaccharide-Induced Mice.
Sign Up to like & getrecommendations! Published in 2022 at "ACS chemical neuroscience"
DOI: 10.1021/acschemneuro.2c00348
Abstract: Depression is a serious mental illness, mainly characterized as large mood swings and sleep, diet, and cognitive function disorders. NLPR3, one of the inflammasomes that can be activated by a variety of stimuli to promote… read more here.
Keywords: neuroinflammation; lps induced; hippocampus; inhibiting nlrp3 ... See more keywords
Neuroprotective Effects and Related Mechanisms of Echinacoside in MPTP-Induced PD Mice
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DOI: 10.2147/ndt.s299685
Abstract: Objective To explore the neuroprotective effect and the related mechanisms of echinacoside (ECH) in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced Parkinson’s disease (PD) mice. Methods Parkinson’s disease is induced in mice by MPTP and the neurobehaviors of mice in… read more here.
Keywords: expression; mptp induced; related mechanisms; induced mice ... See more keywords
Roflumilast Protects against Neuroinflammatory Alterations in Brain Tissues of Lipopolysaccharide-Induced Mice Model.
Sign Up to like & getrecommendations! Published in 2023 at "Current Alzheimer research"
DOI: 10.2174/1567205020666230503141817
Abstract: BACKGROUND Microglial overactivation promotes the production of various second messengers and inflammatory markers in brain tissue, resulting in neuroinflammation and neurodegeneration, which may lead to cognitive decline. The cyclic nucleotides are one of the important… read more here.
Keywords: roflumilast; brain; brain tissues; model ... See more keywords