Cepharanthine, a bisbenzylisoquinoline alkaloid, inhibits lipopolysaccharide-induced microglial activation.
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DOI: 10.1691/ph.2019.9562
Abstract: Activation of microglial cells in the brain has been considered to be associated with various neurodegenerative diseases (NDD). In this study, cepharanthine, a bisbenzylisoquinoline alkaloid, was found to inhibit lipopolysaccharide (LPS)-induced microglial activation. Cepharanthine suppressed… read more here.
Keywords: bisbenzylisoquinoline alkaloid; induced microglial; cepharanthine; cepharanthine bisbenzylisoquinoline ... See more keywords
Nicotinamide n-Oxide Attenuates HSV-1-Induced Microglial Inflammation through Sirtuin-1/NF-κB Signaling
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DOI: 10.3390/ijms232416085
Abstract: HSV-1 is a typical neurotropic virus that infects the brain and causes keratitis, cold sores, and occasionally, acute herpes simplex encephalitis (HSE). The large amount of proinflammatory cytokines induced by HSV-1 infection is an important… read more here.
Keywords: nicotinamide oxide; hsv induced; infection; microglial inflammation ... See more keywords