PDK4 suppresses high glucose-induced microglial ferroptosis by restricting pro-ferroptotic PUFA biosynthesis.
Sign Up to like & getrecommendations! Published in 2025 at "Neuroreport"
DOI: 10.1097/wnr.0000000000002234
Abstract: BACKGROUND Diabetes significantly elevates the risk of neurodegenerative disorders, including Alzheimer's disease and Parkinson's disease, indicating shared pathophysiological mechanisms. While ferroptosis is increasingly implicated in neurodegeneration, microglia - highly vulnerable to ferroptosis - may mediate… read more here.
Keywords: high glucose; induced microglial; microglial ferroptosis; ferroptosis ... See more keywords
Cepharanthine, a bisbenzylisoquinoline alkaloid, inhibits lipopolysaccharide-induced microglial activation.
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DOI: 10.1691/ph.2019.9562
Abstract: Activation of microglial cells in the brain has been considered to be associated with various neurodegenerative diseases (NDD). In this study, cepharanthine, a bisbenzylisoquinoline alkaloid, was found to inhibit lipopolysaccharide (LPS)-induced microglial activation. Cepharanthine suppressed… read more here.
Keywords: bisbenzylisoquinoline alkaloid; induced microglial; cepharanthine; cepharanthine bisbenzylisoquinoline ... See more keywords
Nicotinamide n-Oxide Attenuates HSV-1-Induced Microglial Inflammation through Sirtuin-1/NF-κB Signaling
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DOI: 10.3390/ijms232416085
Abstract: HSV-1 is a typical neurotropic virus that infects the brain and causes keratitis, cold sores, and occasionally, acute herpes simplex encephalitis (HSE). The large amount of proinflammatory cytokines induced by HSV-1 infection is an important… read more here.
Keywords: nicotinamide oxide; hsv induced; infection; microglial inflammation ... See more keywords