Inhibition of the BNIP3/NIX‐dependent mitophagy aggravates copper‐induced mitochondrial dysfunction in duck renal tubular epithelial cells
Sign Up to like & getrecommendations! Published in 2022 at "Environmental Toxicology"
DOI: 10.1002/tox.23704
Abstract: The accumulation of copper (Cu) in the organisms could lead to kidney damage by causing mitochondrial dysfunction. Given that mitochondria are one of the targets of Cu poisoning, this study aimed to investigate the role… read more here.
Keywords: induced mitochondrial; bnip3 nix; renal tubular; mitochondrial dysfunction ... See more keywords
Cadmium induces mitochondrial dysfunction via SIRT1 suppression‐mediated oxidative stress in neuronal cells
Sign Up to like & getrecommendations! Published in 2022 at "Environmental Toxicology"
DOI: 10.1002/tox.23724
Abstract: Cadmium is a widespread environmental contaminant and its neurotoxicity has raised serious concerns. Mitochondrial dysfunction is a key event in Cd‐induced nervous system disease; however, the exact molecular mechanism involved has not been fully elucidated.… read more here.
Keywords: induced mitochondrial; oxidative stress; mitochondrial dysfunction; dysfunction ... See more keywords
Polystyrene exacerbates cadmium-induced mitochondrial damage to lung by blocking autophagy in mice.
Sign Up to like & getrecommendations! Published in 2023 at "Environmental toxicology"
DOI: 10.1002/tox.23804
Abstract: Cadmium (Cd) is an environmental heavy metal, and its accumulation is harmful to animal and human health. The cytotoxicity of Cd includes oxidative stress, apoptosis, and mitochondrial histopathological changes. Furthermore, polystyrene (PS) is a kind… read more here.
Keywords: damage; induced mitochondrial; blocking autophagy; lung ... See more keywords
Discovery of non-peptidic small molecule inhibitors of cyclophilin D as neuroprotective agents in Aβ-induced mitochondrial dysfunction
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Computer-Aided Molecular Design"
DOI: 10.1007/s10822-017-0067-9
Abstract: Cyclophilin D (CypD) is a mitochondria-specific cyclophilin that is known to play a pivotal role in the formation of the mitochondrial permeability transition pore (mPTP).The formation and opening of the mPTP disrupt mitochondrial homeostasis, cause… read more here.
Keywords: small molecule; cypd; induced mitochondrial; mitochondrial dysfunction ... See more keywords
Protective Effect of Pyrroloquinoline Quinone on TNF-α-induced Mitochondrial Injury in Chondrocytes
Sign Up to like & getrecommendations! Published in 2021 at "Current Medical Science"
DOI: 10.1007/s11596-020-2248-3
Abstract: Osteoarthritis (OA) is a degenerative disease characterized by matrix degradation and cell death leading to a gradual loss of articular cartilage integrity. As a bacterial synthesis of quinine, pyrroloquinoline quinone (PQQ) is a strong redox… read more here.
Keywords: tnf induced; pqq; pyrroloquinoline quinone; induced mitochondrial ... See more keywords
Autophagy attenuates copper-induced mitochondrial dysfunction by regulating oxidative stress in chicken hepatocytes.
Sign Up to like & getrecommendations! Published in 2018 at "Chemosphere"
DOI: 10.1016/j.chemosphere.2018.03.192
Abstract: Copper (Cu) is an essential trace element that is required for the catalysis of several cellular enzymes. Excessive Cu could induce hepatotoxicity in humans and multiple animals. The purpose of this study was to investigate… read more here.
Keywords: dysfunction regulating; chicken hepatocytes; mitochondrial dysfunction; regulating oxidative ... See more keywords
Clusterin alleviates Cr(VI)-induced mitochondrial apoptosis in L02 hepatocytes via inhibition of Ca2+-ROS-Drp1-mitochondrial fission axis.
Sign Up to like & getrecommendations! Published in 2020 at "Ecotoxicology and environmental safety"
DOI: 10.1016/j.ecoenv.2020.111326
Abstract: Hexavalent chromium [Cr(VI)] is ubiquitous in the environment and is commonly used in various industrial processes. Clusterin (CLU) is an extracellular chaperone protein which exerts the anti-apoptotic function. In this study, we aimed to explore… read more here.
Keywords: mitochondrial apoptosis; apoptosis; ca2; mitochondrial fission ... See more keywords
Puerarin attenuates palmitate‐induced mitochondrial dysfunction, impaired mitophagy and inflammation in L6 myotubes
Sign Up to like & getrecommendations! Published in 2018 at "Life Sciences"
DOI: 10.1016/j.lfs.2018.05.041
Abstract: Aims: High level of saturated fatty acids leads to mitochondrial dysfunction and inflammation in the development of insulin resistance in skeletal muscle. We recently found that puerarin improved impaired insulin signaling in skeletal muscle in… read more here.
Keywords: palmitate induced; dysfunction; inflammation; mitochondrial dysfunction ... See more keywords
Astaxanthin Protects Against Heat-induced Mitochondrial Alterations in Mouse Hypothalamus
Sign Up to like & getrecommendations! Published in 2021 at "Neuroscience"
DOI: 10.1016/j.neuroscience.2021.09.010
Abstract: The hypothalamus plays an essential role in regulating whole-body energy and temperature homeostasis when adapting to environmental changes. We previously reported that heat exposure causes mitochondrial dysfunction and apoptosis in mouse skeletal muscle, and pretreatment… read more here.
Keywords: hypothalamus; heat induced; heat exposure; heat ... See more keywords
Metformin alleviates lead-induced mitochondrial fragmentation via AMPK/Nrf2 activation in SH-SY5Y cells
Sign Up to like & getrecommendations! Published in 2020 at "Redox Biology"
DOI: 10.1016/j.redox.2020.101626
Abstract: As a widely acknowledged environmental pollutant, lead (Pb) exhibits neurological toxicity primarily due to the vulnerability of neural system. It is suggested that Pb could perturb mitochondrial function, triggering the following disturbance of cellular homeostasis.… read more here.
Keywords: metformin; activation; fragmentation; fragmentation via ... See more keywords
Notoginsenoside R1 alleviates TEGDMA-induced mitochondrial apoptosis in preodontoblasts through activation of Akt/Nrf2 pathway-dependent mitophagy.
Sign Up to like & getrecommendations! Published in 2021 at "Toxicology and applied pharmacology"
DOI: 10.1016/j.taap.2021.115482
Abstract: Incomplete polymerization or biodegradation of dental resin materials results in the release of resin monomers such as triethylene glycol dimethacrylate (TEGDMA), causing severe injury of dental pulp cells. To date, there has been no efficient… read more here.
Keywords: nrf2 pathway; tegdma induced; akt nrf2; mitophagy ... See more keywords