A bone morphogenetic protein signaling inhibitor, LDN193189, converts ischemia-induced multipotent stem cells into neural stem/progenitor cell-like cells.
Sign Up to like & getrecommendations! Published in 2022 at "Stem cells and development"
DOI: 10.1089/scd.2022.0139
Abstract: Stem cell therapy is used to restore neurological function in stroke patients. We have previously reported that ischemia-induced multipotent stem cells (iSCs), which are likely derived from brain pericytes, develop in post-stroke human and mouse… read more here.
Keywords: ischemia induced; multipotent stem; induced multipotent; iscs ... See more keywords
Transplantation of Human Brain-Derived Ischemia-Induced Multipotent Stem Cells Ameliorates Neurological Dysfunction in Mice After Stroke.
Sign Up to like & getrecommendations! Published in 2023 at "Stem cells translational medicine"
DOI: 10.1093/stcltm/szad031
Abstract: We recently demonstrated that injury/ischemia-induced multipotent stem cells (iSCs) develop within post-stroke human brains. Because iSCs are stem cells induced under pathological conditions, such as ischemic stroke, the use of human brain-derived iSCs (h-iSCs) may… read more here.
Keywords: ischemia induced; induced multipotent; transplantation; stem ... See more keywords