DNA polymerase kappa counteracts inflammation‐induced mutagenesis in multiple organs of mice
Sign Up to like & getrecommendations! Published in 2019 at "Environmental and Molecular Mutagenesis"
DOI: 10.1002/em.22272
Abstract: In vitro studies indicate that DNA polymerase kappa (Polκ) is able to accurately and efficiently perform DNA synthesis using templates containing various types of DNA damage, including benzo[a]pyrene (BP)‐induced N2‐deoxyguanosine adducts. In this study, we… read more here.
Keywords: polk; polk mice; induced mutagenesis; colon ... See more keywords
UV-induced mutagenesis of Beauveria bassiana (Hypocreales: Clavicipitaceae) yields two hypervirulent isolates with different transcriptomic profiles.
Sign Up to like & getrecommendations! Published in 2023 at "Pest management science"
DOI: 10.1002/ps.7452
Abstract: BACKGROUND The fall armyworm, Spodoptera frugiperda (Lepidoptera: Noctuidae) can infest over 300 plant species and cause huge economic losses. Beauveria bassiana (Hypocreales: Clavicipitaceae) is one of the most widely used entomopathogenic fungi (EPF). Unfortunately, the… read more here.
Keywords: beauveria bassiana; induced mutagenesis; bassiana; hypocreales clavicipitaceae ... See more keywords
Plant Genome Editing and the Relevance of Off-Target Changes1[OPEN]
Sign Up to like & getrecommendations! Published in 2020 at "Plant Physiology"
DOI: 10.1104/pp.19.01194
Abstract: With well-designed protocols and guide RNAs, off-target changes induced by site-directed nucleases are negligible with fewer genetic differences than from standing variation or induced mutagenesis. Site-directed nucleases (SDNs) used for targeted genome editing are powerful… read more here.
Keywords: genome editing; plant; target; site ... See more keywords
MTOR signaling orchestrates stress-induced mutagenesis, facilitating adaptive evolution in cancer
Sign Up to like & getrecommendations! Published in 2020 at "Science"
DOI: 10.1126/science.aau8768
Abstract: How cancer cells adapt to stress Bacteria adapt to harsh conditions such as antibiotic exposure by acquiring new mutations, a process called stress-induced mutagenesis. Cipponi et al. investigated whether similar programs of mutagenesis play a… read more here.
Keywords: mutagenesis; drug; stress induced; induced mutagenesis ... See more keywords
APOBEC-Induced Mutagenesis in Cancer.
Sign Up to like & getrecommendations! Published in 2022 at "Annual review of genetics"
DOI: 10.1146/annurev-genet-072920-035840
Abstract: The initiation, progression, and relapse of cancers often result from mutations occurring within somatic cells. Consequently, processes that elevate mutation rates accelerate carcinogenesis and hinder the development of long-lasting therapeutics. Recent sequencing of human cancer… read more here.
Keywords: apobec induced; induced mutagenesis; mutation; cancer ... See more keywords
Resistance-Linked Stress-Induced Mutagenesis Is MTOR-Mediated in Cancer.
Sign Up to like & getrecommendations! Published in 2020 at "Cancer discovery"
DOI: 10.1158/2159-8290.cd-rw2020-090
Abstract: MTOR was a critical node modulating stress-induced mutagenesis (SIM) in cancer in vitro and in vivo. read more here.
Keywords: mtor; stress induced; cancer; induced mutagenesis ... See more keywords
Induced Mutagenesis for the Creation of New Starting Material in Sunflower Breeding
Sign Up to like & getrecommendations! Published in 2019 at "Helia"
DOI: 10.1515/helia-2017-0024
Abstract: Abstract The article colligates data of studies on the variability of quantitative and qualitative traits in mutant sunflower M1-M3 generations affected by dimethyl sulfate (DMS) (0.01, 0.05 %) and gamma rays (120; 150 Gy), frequencies and range… read more here.
Keywords: gamma; mutant families; breeding; gamma rays ... See more keywords