Astragaloside IV attenuates chronic intermittent hypoxia-induced myocardial injury by modulating Ca2+ homeostasis.
Sign Up to like & getrecommendations! Published in 2020 at "Cell biochemistry and function"
DOI: 10.1002/cbf.3538
Abstract: Obstructive sleep apnea syndrome (OSAS) is an important consequence of chronic intermittent hypoxia (CIH). Astragaloside IV (AS-IV) exerts multiple protective effects in diverse diseases. However, whether AS-IV can attenuate CIH-induced myocardial injury is unclear. In… read more here.
Keywords: induced myocardial; myocardial injury; cih; intermittent hypoxia ... See more keywords
Downregulation of miR‐34c‐5p alleviates chronic intermittent hypoxia‐induced myocardial damage by targeting sirtuin 1
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Biochemical and Molecular Toxicology"
DOI: 10.1002/jbt.23164
Abstract: Numerous microRNAs (miRs) are abnormally expressed in response to hypoxia‐induced myocardial damage. Herein, miR‐34c‐5p as a potential pharmaco‐target was investigated in a mouse model of chronic intermittent hypoxia (CIH)‐induced myocardial damage. A mouse model of… read more here.
Keywords: mir 34c; myocardial damage; antagomir 34c; hypoxia ... See more keywords
Role of nitric oxide in mediating the cardioprotective effect of agomelatine against isoproterenol-induced myocardial injury in rats
Sign Up to like & getrecommendations! Published in 2020 at "Naunyn-Schmiedeberg's Archives of Pharmacology"
DOI: 10.1007/s00210-020-01860-y
Abstract: Myocardial infarction (M/I) is a common cause of mortality worldwide. Agomelatine (AGO), a potent melatonin receptor agonist, proved to have an anti-inflammatory and antioxidant effect. The present study aimed to explore the cardioprotective effect of AGO… read more here.
Keywords: iso; group; myocardial injury; effect ... See more keywords
Sepsis-Induced Myocardial Dysfunction (SIMD): the Pathophysiological Mechanisms and Therapeutic Strategies Targeting Mitochondria
Sign Up to like & getrecommendations! Published in 2020 at "Inflammation"
DOI: 10.1007/s10753-020-01233-w
Abstract: Sepsis is a lethal syndrome with multiple organ failure caused by an inappropriate host response to infection. Cardiac dysfunction is one of the important complications of sepsis, termed sepsis-induced myocardial dysfunction (SIMD), which is characterized… read more here.
Keywords: sepsis; myocardial dysfunction; dysfunction simd; dysfunction ... See more keywords
RIP1/RIP3/MLKL-mediated necroptosis contributes to vinblastine-induced myocardial damage
Sign Up to like & getrecommendations! Published in 2020 at "Molecular and Cellular Biochemistry"
DOI: 10.1007/s11010-020-03985-3
Abstract: Vinblastine (VBL) has been considered as a first-line anti-tumor drug for many years. However, vinblastine-caused myocardial damage has been continually reported. The underlying molecular mechanism of the myocardial damage remains unknown. Here, we show that… read more here.
Keywords: myocardial damage; necroptosis; vinblastine induced; damage ... See more keywords
Exercise Protects Sympathetic Stress-Induced Myocardial Fibrosis by Regulating Cytokines
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cardiovascular Translational Research"
DOI: 10.1007/s12265-019-09933-x
Abstract: Cardiovascular diseases are often caused by overactivation of β-adrenergic receptors (β-ARs) during acute sympathetic stress. As cardiomyocytes of adult mammals have lost significant proliferative capacity, the connective tissue replacement occurs once cardiomyocytes are damaged, thereby… read more here.
Keywords: fibrosis; sympathetic stress; myocardial fibrosis; exercise ... See more keywords
Reversible biventricular myocardial dysfunction induced by carbon monoxide poisoning
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Echocardiography"
DOI: 10.1007/s12574-018-0402-8
Abstract: A 52-year-old male with no previous history of heart disease was referred to our emergency room for impaired consciousness due to intentional exposure to carbon monoxide (CO). His Japan Coma Scale was 100 and his… read more here.
Keywords: myocardial dysfunction; dysfunction; tte; carbon monoxide ... See more keywords
Downregulation of PI3K‐&ggr; in a mouse model of sepsis‐induced myocardial dysfunction
Sign Up to like & getrecommendations! Published in 2017 at "Cytokine"
DOI: 10.1016/j.cyto.2017.04.018
Abstract: HighlightsMechanism for SIMD.Relies on PI3K/AKT pathway.PI3K might be a therapeutic target. Abstract A key component during sepsis is the phosphoinositide 3‐kinase (PI3K)/protein kinase B (Akt) signaling pathway, of which the PI3K‐&ggr; isoform is a major… read more here.
Keywords: pi3k ggr; pi3k; induced myocardial; sepsis induced ... See more keywords
ITRAQ-based proteomics reveals the potential mechanism of fluoride-induced myocardial contraction function damage.
Sign Up to like & getrecommendations! Published in 2020 at "Ecotoxicology and environmental safety"
DOI: 10.1016/j.ecoenv.2020.110605
Abstract: Fluorosis is a worldwide public health problem, and its adverse effects on the heart have been confirmed by many studies. Abnormal myocardial contractions are often associated with impairment of cardiac function as a cause or… read more here.
Keywords: fluoride induced; mechanism; myocardial contraction; function ... See more keywords
CYP2J2‐derived EETs attenuated ethanol‐induced myocardial dysfunction through inducing autophagy and reducing apoptosis
Sign Up to like & getrecommendations! Published in 2018 at "Free Radical Biology and Medicine"
DOI: 10.1016/j.freeradbiomed.2018.02.009
Abstract: ABSTRACT Chronic excessive drinking leads to myocardial contractile dysfunction and dilated cardiomyopathy, where ethanol toxicity plays an essential role. Cytochrome P450 (CYP) epoxygenases metabolize arachidonic acids to form epoxyeicosatrienoic acids (EETs), which exert beneficial roles… read more here.
Keywords: myocardial dysfunction; apoptosis; dysfunction; cyp2j2 ... See more keywords
Cardioprotective effects of a Fructus Aurantii polysaccharide in isoproterenol-induced myocardial ischemic rats.
Sign Up to like & getrecommendations! Published in 2019 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2019.11.063
Abstract: CALB-3, a purified acidic hetero-polysaccharide isolated from Fructus aurantii, has been shown to exert cardioprotective effects in vitro. Recently, we investigated the protective effects of CALB-3 on myocardial injury and its possible mechanisms of action… read more here.
Keywords: isoproterenol; cardioprotective effects; fructus aurantii; effects fructus ... See more keywords