Ogerin mediated inhibition of TGF-β(1) induced myofibroblast differentiation is potentiated by acidic pH
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DOI: 10.1371/journal.pone.0271608
Abstract: Transforming growth factor beta (TGF-β) induced myofibroblast differentiation is central to the pathological scarring observed in Idiopathic Pulmonary Fibrosis (IPF) and other fibrotic diseases. Our lab has recently identified expression of GPR68 (Ovarian Cancer Gene… read more here.
Keywords: myofibroblast differentiation; inhibition; tgf induced; induced myofibroblast ... See more keywords
JNK and p38 Inhibitors Prevent Transforming Growth Factor-β1-Induced Myofibroblast Transdifferentiation in Human Graves’ Orbital Fibroblasts
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DOI: 10.3390/ijms22062952
Abstract: Transforming growth factor-β1 (TGF-β1)-induced myofibroblast transdifferentiation from orbital fibroblasts is known to dominate tissue remodeling and fibrosis in Graves’ ophthalmopathy (GO). However, the signaling pathways through which TGF-β1 activates Graves’ orbital fibroblasts remain unclear. This… read more here.
Keywords: graves orbital; orbital fibroblasts; growth factor; induced myofibroblast ... See more keywords
The Soluble Guanylate Cyclase Stimulator BAY 41-2272 Attenuates Transforming Growth Factor β1-Induced Myofibroblast Differentiation of Human Corneal Keratocytes
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DOI: 10.3390/ijms232315325
Abstract: Corneal transparency, necessary for vision and depending on the high organization of stromal extracellular matrix, is maintained by keratocytes. Severe or continuous corneal injuries determine exaggerated healing responses resulting in the formation of irreversible fibrotic… read more here.
Keywords: bay; bay 2272; corneal; induced myofibroblast ... See more keywords