Genomewide Association Study of Statin‐Induced Myopathy in Patients Recruited Using the UK Clinical Practice Research Datalink
Sign Up to like & getrecommendations! Published in 2019 at "Clinical Pharmacology and Therapeutics"
DOI: 10.1002/cpt.1557
Abstract: Statins can be associated with myopathy. We have undertaken a genomewide association study (GWAS) to discover and validate genetic risk factors for statin‐induced myopathy in a “real‐world” setting. One hundred thirty‐five patients with statin myopathy… read more here.
Keywords: clinical practice; statin induced; association; genomewide association ... See more keywords
Statin-induced myopathy SLCO1B1 521T > C is associated with prediabetes, high body mass index and normal lipid profile in Emirati population.
Sign Up to like & getrecommendations! Published in 2018 at "Diabetes research and clinical practice"
DOI: 10.1016/j.diabres.2018.03.014
Abstract: BACKGROUND Statin-induced myopathy has been linked to the C allele of a single nucleotide polymorphism (SNP) (rs4149056) of SLCO1B1 gene. This effect is more significant, but not restricted to simvastatin. Many studies have included European,… read more here.
Keywords: lipid profile; statin induced; induced myopathy; population ... See more keywords
Vitamin D supplementation rescues simvastatin induced myopathy in mice via improving mitochondrial cristae shape.
Sign Up to like & getrecommendations! Published in 2020 at "Toxicology and applied pharmacology"
DOI: 10.1016/j.taap.2020.115076
Abstract: Statin induced myopathy (SIM) is a main deleterious effect leading to the poor treatment compliance, while the preventive or therapeutic treatments are absent. Mounting evidences demonstrated that vitamin D plays a vital role in muscle… read more here.
Keywords: induced myopathy; supplementation; vitamin supplementation; mitochondrial cristae ... See more keywords
Sulfasalazine‐induced myopathy in a patient with an acute spondyloarthritis
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DOI: 10.1111/imj.15654
Abstract: A 26-year-old Filipino man presented to his rheumatologist with symptoms of weakness in his lower limbs after noticing that activities such as running and walking up stairs had become quite difficult. He had not performed… read more here.
Keywords: sulfasalazine induced; patient; sulfasalazine; acute spondyloarthritis ... See more keywords
The role of circulatory chemokines in sepsis-induced myopathy in mice
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DOI: 10.1152/physiol.2023.38.s1.5792235
Abstract: BACKGROUND: Sepsis is a condition of life-threatening organ dysfunction caused by a dysregulated host response to infection and carries a high risk of mortality. A rapidly growing number of “sepsis survivors” experience persistent and severe… read more here.
Keywords: sepsis; induced myopathy; role; serum ... See more keywords
Chemotherapy-Induced Myopathy: The Dark Side of the Cachexia Sphere
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DOI: 10.3390/cancers13143615
Abstract: Simple Summary In addition to cancer-related factors, anti-cancer chemotherapy treatment can drive life-threatening body wasting in a syndrome known as cachexia. Emerging evidence has described the impact of several key chemotherapeutic agents on skeletal muscle… read more here.
Keywords: cachexia; chemotherapy induced; cancer; induced myopathy ... See more keywords
Transcriptomic Profiling of Rectus Abdominis Muscle in Women with Gestational Diabetes-Induced Myopathy: Characterization of Pathophysiology and Potential Muscle Biomarkers of Pregnancy-Specific Urinary Incontinence
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms232112864
Abstract: Gestational diabetes mellitus (GDM) is recognized as a “window of opportunity” for the future prediction of such complications as type 2 diabetes mellitus and pelvic floor muscle disorders, including urinary incontinence and genitourinary dysfunction. Translational… read more here.
Keywords: rectus abdominis; induced myopathy; muscle; gestational diabetes ... See more keywords